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Dyrk4 Gene Detail
Summary
  • Symbol
    Dyrk4
  • Name
    dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4
  • Synonyms
    Dyrk4a, Dyrk4b
  • Feature Type
    protein coding gene
  • IDs
    MGI:1330292
    NCBI Gene: 101320
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:126876020-126921839 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 61.92 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    328 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1330292
protein coding gene Chr6:126876020-126921864 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031307
protein coding gene Chr6:130353790-130396598 (-)
A/J MGP_AJ_G0031278
protein coding gene Chr6:125388664-125431193 (-)
AKR/J MGP_AKRJ_G0031206
protein coding gene Chr6:128784755-128830958 (-)
BALB/cJ MGP_BALBcJ_G0031285
protein coding gene Chr6:124963043-125005998 (-)
C3H/HeJ MGP_C3HHeJ_G0031009
protein coding gene Chr6:128909938-128953338 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031742
protein coding gene Chr6:133752180-133802348 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028890
protein coding gene Chr6:122574235-122616250 (-)
CAST/EiJ MGP_CASTEiJ_G0030390
protein coding gene Chr6:129108311-129149536 (-)
CBA/J MGP_CBAJ_G0030970
protein coding gene Chr6:138883605-138931528 (-)
DBA/2J MGP_DBA2J_G0031126
protein coding gene Chr6:124287604-124330775 (-)
FVB/NJ MGP_FVBNJ_G0031075
protein coding gene Chr6:123217798-123260079 (-)
LP/J MGP_LPJ_G0031206
protein coding gene Chr6:130466937-130511401 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031114
protein coding gene Chr6:142857032-142904628 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031777
protein coding gene Chr6:128740753-128788081 (-)
PWK/PhJ MGP_PWKPhJ_G0030105
protein coding gene Chr6:122551324-122593820 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029934
protein coding gene Chr6:126817256-126860470 (-)
WSB/EiJ MGP_WSBEiJ_G0030475
protein coding gene Chr6:129108371-129152576 (-)



Homology
more
  • Human Ortholog
    DYRK4, dual specificity tyrosine phosphorylation regulated kinase 4
  • Vertebrate Orthologs
    8
  • Human Ortholog
    DYRK4, dual specificity tyrosine phosphorylation regulated kinase 4
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 8798
    neXtProt AC: NX_Q9NR20
    UniProt: Q9NR20

  • Chr Location
    12p13.32; chr12:4590072-4613888 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    3 phenotype references
Contrary to expectation, homozygous null males are fertile and do not exhibit any obvious dysfunction in spermatogenesis, sperm motility and fertilization.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000030345 Ensembl Gene Model | MGI Sequence Detail 45820 C57BL/6J ±  kb
transcript ENSMUST00000078521 Ensembl | MGI Sequence Detail 2252 Not Applicable  
polypeptide ENSMUSP00000077606 Ensembl | MGI Sequence Detail 632 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 3
    cDNA 3

    Microarray probesets 2
Other
Accession IDs
less
MGI:1330291, MGI:2141638
References
more
  • Summaries
    All 22
    Gene Ontology 4
    Phenotypes 3
  • Earliest
    J:50326 Becker W, et al., Sequence characteristics, subcellular localization, and substrate specificity of DYRK-related kinases, a novel family of dual specificity protein kinases. J Biol Chem. 1998 Oct 2;273(40):25893-902
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory