Dyrk4 MGI Mouse Gene Detail - MGI:1330292 - dual-specificity tyrosine phosphorylation regulated kinase 4

Symbol

Dyrk4
Name

dual-specificity tyrosine phosphorylation regulated kinase 4
Synonyms

Dyrk4a, Dyrk4b

Feature Type

protein coding gene
IDs

MGI:1330292
NCBI Gene: 101320
Alliance

genome feature page
Transcription Start Sites

3 TSS

Sequence Map

Chr6:126852983-126898802 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 61.92 cM
Mapping Data

1 experiment

SNPs within 2kb

1029 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1330292	protein coding gene	Chr6:126852983-126899039 (-)
129S1/SvImJ	ENSMUSG00200043124	protein coding gene	Chr6:123926547-123972382 (-)
A/J	ENSMUSG00195029178	protein coding gene	Chr6:123354755-123396952 (-)
AKR/J	ENSMUSG00220025615	protein coding gene	Chr6:122216356-122258545 (-)
BALB/cJ	ENSMUSG00180033520	protein coding gene	Chr6:123691757-123733954 (-)
C3H/HeJ	ENSMUSG00175031216	protein coding gene	Chr6:123355463-123397662 (-)
C57BL/6NJ	ENSMUSG00215019010	protein coding gene	Chr6:123682515-123728363 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0028890	protein coding gene	Chr6:122574235-122616250 (-)
CAST/EiJ	ENSTCUG00005037878	protein coding gene	Chr6:123534387-123576730 (-)
CBA/J	ENSMUSG00210016059	protein coding gene	Chr6:123392063-123434246 (-)
DBA/2J	ENSMUSG00185038410	protein coding gene	Chr6:124092341-124134532 (-)
FVB/NJ	ENSMUSG00205023566	protein coding gene	Chr6:122963805-123006011 (-)
JF1/MsJ	ENSUMUG00000032931	protein coding gene	Chr6:122512036-122554444 (-)
LP/J	ENSMUSG00230043752	protein coding gene	Chr6:125289539-125331722 (-)
NOD/ShiLtJ	ENSMUSG00190031271	protein coding gene	Chr6:123068093-123110316 (-)
NZO/HlLtJ	ENSMUSG00225015185	protein coding gene	Chr6:127322552-127364828 (-)
PWK/PhJ	ENSLUMG00010047154	protein coding gene	Chr6:121758120-121800153 (-)
SPRET/EiJ	ENSMSPG00010036776	protein coding gene	Chr6:124614210-124655852 (-)
WSB/EiJ	ENSIUOG00005045084	protein coding gene	Chr6:123783016-123825124 (-)

Human Ortholog

DYRK4, dual specificity tyrosine phosphorylation regulated kinase 4

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DYRK4, dual specificity tyrosine phosphorylation regulated kinase 4
Links

HGNC:3095

NCBI Gene ID: 8798

UniProt: Q9NR20
Chr Location

12p13.32; chr12:4562208-4615302 (+) GRCh38

MGI Vertebrate Homology

Dyrk4 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: DYRK4
Gene Tree

Dyrk4

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
6 phenotype references

All Mutations and Alleles

7
Endonuclease-mediated

4
Targeted

3
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

31 strains or lines available

Contrary to expectation, homozygous null males are fertile and do not exhibit any obvious dysfunction in spermatogenesis, sperm motility and fertilization.

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All GO Annotations

13
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

597
cDNA Data

3
Literature Summary

1

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

49
RefSeq

18
UniProt

2
CCDS

CCDS20559.2

Ensembl

ENSMUSG00000030345 (Evidence)
NCBI Gene

101320

			Length	Strain/Species	Flank
genomic	ENSMUSG00000030345	Ensembl Gene Model \| MGI Sequence Detail	45820	C57BL/6J	± kb
transcript	ENSMUST00000078521	Ensembl \| MGI Sequence Detail	2252	Not Applicable
polypeptide	ENSMUSP00000077606	Ensembl \| MGI Sequence Detail	632	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000006785 dual specificity tyrosine-phosphorylation-regulated kinase 4

(term hierarchy)
EC

2.7.12.1
InterPro Domains

IPR042521 Dual specificity tyrosine-phosphorylation-regulated kinase

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR050494 Serine/threonine and dual-specificity kinase

IPR008271 Serine/threonine-protein kinase, active site

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All nucleic 3

cDNA 3

Microarray probesets 2

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MGI:1330291, MGI:2141638

Summaries

All 28

Developmental Gene Expression 1

Gene Ontology 6

Phenotypes 6
Earliest

J:50326 Becker W, et al., Sequence characteristics, subcellular localization, and substrate specificity of DYRK-related kinases, a novel family of dual specificity protein kinases. J Biol Chem. 1998 Oct 2;273(40):25893-902
Latest

J:376309 Viscomi MP, et al., Embryonic and placental factors are linked with the development of autism-like behaviors in the BTBR mouse model. Neuroscience. 2025 Dec 5;593:18-28

TSS for Dyrk4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr63351	Chr6:126898767-126898790 (-)	23 bp
Tssr63350	Chr6:126898754-126898764 (-)	43 bp
Tssr63349	Chr6:126854260-126854293 (-)	44,525 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24