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Ovol1 Gene Detail
Summary
  • Symbol
    Ovol1
  • Name
    ovo like zinc finger 1
  • Synonyms
    movo1, Ovo1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1330290
    NCBI Gene: 18426
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr19:5549137-5560575 bp, - strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      11439 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 4.34 cM, cytoband A
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    OVOL1, ovo like transcriptional repressor 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    OVOL1, ovo like transcriptional repressor 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HOVO1
  • Links
    NCBI Gene ID: 5017
    neXtProt AC: NX_O14753
    UniProt: O14753

  • Chr Location
    11q13.1; chr11:65787034-65797219 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    32 phenotypes from 2 alleles in 3 genetic backgrounds
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Null mutant homozygotes show reduced growth, abnormal hair, and cystic kidneys. Females are subfertile with dilated uterus and cervix, and constricted or imperforate vagina. Mutant males have small testes, with few mature germ cells.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18426 NCBI Gene Model | MGI Sequence Detail 11439 C57BL/6J ±  kb
    transcript NM_019935 RefSeq | MGI Sequence Detail 2900 C57BL/6  
    polypeptide Q9WTJ2 UniProt | EBI | MGI Sequence Detail 267 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      65 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 27
      Genomic 1
      cDNA 25
      Primer pair 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2147769
    References
    more
    • Summaries
      All 43
      Developmental Gene Expression 14
      Gene Ontology 7
      Phenotypes 8
    • Earliest
      J:23315 Farese RV Jr, et al., Knockout of the mouse apolipoprotein B gene results in embryonic lethality in homozygotes and protection against diet-induced hypercholesterolemia in heterozygotes. Proc Natl Acad Sci U S A. 1995 Feb 28;92(5):1774-8
    • Latest
      J:236599 Dickinson ME, et al., High-throughput discovery of novel developmental phenotypes. Nature. 2016 Sep 14;537(7621):508-514

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    06/05/2018
    MGI 6.12
    The Jackson Laboratory