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Ovol1
Gene Detail
 Symbol
Name
ID
Ovol1
OVO homolog-like 1 (Drosophila)
MGI:1330290
Synonyms movo1, Ovo1
Feature Type protein coding gene
Genetic Map
Chromosome 19
4.34 cM, cytoband A
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr19:5549137-5560575 bp, - strand
From NCBI annotation of GRCm38

  11439 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3354  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Protein SuperFamily: transcription factor, Ovol1/Ovol2 types
Gene Tree: Ovol1

Human
homologs
Human Homolog OVOL1, ovo-like zinc finger 1
NCBI Gene ID 5017
neXtProt AC  NX_O14753
Human Synonyms  HOVO1
Human Chr (Location)  11q13; chr11:65787034-65797219 (+)  GRCh38
Alleles
and
phenotypes
All alleles(4) : Targeted(4)
 
Null mutant homozygotes show reduced growth, abnormal hair, and cystic kidneys. Females are subfertile with dilated uterus and cervix, and constricted or imperforate vagina. Mutant males have small testes, with few mature germ cells.
 
Gene Ontology
(GO)
classifications
All GO classifications: (25 annotations)
Process cytoskeleton organization, epidermal cell differentiation, ...
Component nucleus
Function DNA binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (12 records)
Data Summary: Results (105)    Tissues (40)    Images (23)
Theiler Stages: 2, 3, 4, 5, 15, 17, 18, 23, 24, 28
Assay TypeResults
RNA in situ 88
Northern blot 2
RT-PCR 15
cDNA source data(25)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(27) Genomic(1) cDNA(25) Primer pair(1)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000024922 (Evidence)
Entrez Gene18426 (Evidence)
UniGene280225
DFCITC1582281
DoTSDT.486142, DT.60104248
NIA Mouse Gene IndexU019043
Consensus CDS ProjectCCDS29469.1
International Mouse Knockout Project StatusOvol1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 18426 NCBI Gene Model | MGI Sequence Detail 11439 C57BL/6J ±  kb
transcript NM_019935 RefSeq | MGI Sequence Detail 2900 C57BL/6 
polypeptide Q9WTJ2 UniProt | EBI | MGI Sequence Detail 267 Not Applicable 

For the selected sequences
All sequences(32) RefSeq(6) UniProt(2)
Polymorphisms SNPs within 2kb(66 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007087 Zinc finger, C2H2
InterPro IPR015880 Zinc finger, C2H2-like
InterPro IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology PR:000031107 putative transcription factor Ovo-like 1
Graphical View of Protein Domain Structure
References (Earliest) J:23315 Farese RV Jr, et al., Knockout of the mouse apolipoprotein B gene results in embryonic lethality in homozygotes and protection against diet-induced hypercholesterolemia in heterozygotes. Proc Natl Acad Sci U S A. 1995 Feb 28;92(5):1774-8
(Latest) J:194289 Bell SM, et al., Kruppel-like factor 5 controls villus formation and initiation of cytodifferentiation in the embryonic intestinal epithelium. Dev Biol. 2013 Mar 15;375(2):128-39
All references(42)
Other
accession IDs
MGI:2147769

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory