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Ovol1
Gene Detail
Symbol

Name
ID
Ovol1
OVO homolog-like 1 (Drosophila)
MGI:1330290
Synonyms
movo1, Ovo1
Feature Type
protein coding gene
Genetic Map
Chromosome 19
4.34 cM, cytoband A
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr19:5549137-5560575 bp, - strand
From NCBI annotation of GRCm38

  11439 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3354  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: OVOL1
Protein SuperFamily: transcription factor, Ovol1/Ovol2 types
Gene Tree: Ovol1

Human
homologs
OVOL1, ovo-like zinc finger 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 5017
neXtProt AC: NX_O14753

Human Synonyms: HOVO1

Human Chr (Location): 11q13; chr11:65787034-65797219 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
 
Null mutant homozygotes show reduced growth, abnormal hair, and cystic kidneys. Females are subfertile with dilated uterus and cervix, and constricted or imperforate vagina. Mutant males have small testes, with few mature germ cells.
 
Interactions
Ovol1 interacts with 258 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (27 annotations)
Process cytoskeleton organization, epidermal cell differentiation, ...
Component nucleus
Function DNA binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (13 records)
Data Summary: Results (98)    Tissues (35)    Images (23)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 88
Northern blot 2
RT-PCR 8
cDNA source data(25)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: ZFIN ovol1    NEW 
Molecular
reagents
All nucleic(27) Genomic(1) cDNA(25) Primer pair(1)
Microarray probesets(5)
Other database
links
Ensembl Gene Model ENSMUSG00000024922 (Evidence)
Entrez Gene 18426 (Evidence)
UniGene 280225
DFCI TC1582281
DoTS DT.60104248, DT.486142
NIA Mouse Gene Index U019043
Consensus CDS Project CCDS29469.1
International Mouse Phenotyping Consortium Status Ovol1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 18426 NCBI Gene Model | MGI Sequence Detail 11439 C57BL/6J ±  kb
transcript NM_019935 RefSeq | MGI Sequence Detail 2900 C57BL/6 
polypeptide Q9WTJ2 UniProt | EBI | MGI Sequence Detail 267 Not Applicable 

For the selected sequences
All sequences(36) RefSeq(10) UniProt(2)
Polymorphisms
SNPs within 2kb(66 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007087 Zinc finger, C2H2
InterPro IPR015880 Zinc finger, C2H2-like
InterPro IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology PR:000031107 transcription factor Ovo-like 1
Graphical View of Protein Domain Structure
References
(Earliest) J:50844 Dai X, et al., The ovo gene required for cuticle formation and oogenesis in flies is involved in hair formation and spermatogenesis in mice. Genes Dev. 1998 Nov 1;12(21):3452-63
(Latest) J:213415 Lee B, et al., Transcriptional mechanisms link epithelial plasticity to adhesion and differentiation of epidermal progenitor cells. Dev Cell. 2014 Apr 14;29(1):47-58
All references(43)
Other
accession IDs
MGI:2147769

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory