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Cops2
Gene Detail
Symbol

Name
ID
Cops2
COP9 (constitutive photomorphogenic) homolog, subunit 2 (Arabidopsis thaliana)
MGI:1330276
Synonyms
alien homologue, alien-like, Csn2, Sgn2, Trip15
Feature Type
protein coding gene
Genetic Map
Chromosome 2
61.76 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr2:125830304-125859139 bp, - strand
From VEGA annotation of GRCm38

  28836 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3124  Vertebrate Homology Class
1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: COP9 signalosome complex, subunit 2
Gene Tree: Cops2

Mutations,
alleles, and
phenotypes
All mutations/alleles(15) : Gene trapped(12) Targeted(3)
 
Mice homozygous for disruptions in this gene die as embryos very soon after implantation.
 
Interactions
Cops2 interacts with 366 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process cell proliferation, negative regulation of transcription, DNA-templated, ...
Component COP9 signalosome, cytoplasm, ...
Function protein binding, transcription corepressor activity
External Resources: FuncBase
Expression
Literature Summary: (10 records)
Data Summary: Results (149)    Tissues (132)    Images (23)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 2
RNA in situ 111
Northern blot 11
Western blot 25
cDNA source data(209)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(211) Genomic(1) cDNA(209) Primer pair(1)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000015340 (Evidence)
Ensembl Gene ModelENSMUSG00000027206 (Evidence)
Entrez Gene12848 (Evidence)
UniGene3596
DFCITC1583359, TC1572317
NIA Mouse Gene IndexU023297
Consensus CDS ProjectCCDS16679.1, CCDS71133.1
International Mouse Knockout Project StatusCops2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015340 VEGA Gene Model | MGI Sequence Detail 28836 C57BL/6J ±  kb
transcript OTTMUST00000036353 VEGA | MGI Sequence Detail 3392 Not Applicable 
polypeptide OTTMUSP00000016338 VEGA | MGI Sequence Detail 450 Not Applicable 

For the selected sequences
All sequences(58) RefSeq(8) UniProt(7)
Polymorphisms
RFLP(1) : SNPs within 2kb(172 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013143 PCI/PINT associated module
InterPro IPR000717 Proteasome component (PCI) domain
InterPro IPR011990 Tetratricopeptide-like helical
InterPro IPR011991 Winged helix-turn-helix DNA-binding domain
Protein Ontology PR:000005739 COP9 signalosome complex subunit 2
References
(Earliest) J:50270 Wei N, et al., The COP9 complex is conserved between plants and mammals and is related to the 26S proteasome regulatory complex. Curr Biol. 1998 Jul 30-Aug 13;8(16):919-22
(Latest) J:182258 Taher L, et al., Global gene expression analysis of murine limb development. PLoS One. 2011;6(12):e28358
All references(50)
Other
accession IDs
MGI:2138892, MGI:2139517

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory