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Cops2
Gene Detail
Symbol

Name
ID
Cops2
COP9 (constitutive photomorphogenic) homolog, subunit 2 (Arabidopsis thaliana)
MGI:1330276
Synonyms
alien homologue, alien-like, Csn2, Sgn2, Trip15
Feature Type
protein coding gene
Genetic Map
Chromosome 2
61.76 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr2:125830304-125859139 bp, - strand
From VEGA annotation of GRCm38

  28836 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3124  Vertebrate Homology Class
1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: COPS2
Protein SuperFamily: COP9 signalosome complex, subunit 2
Gene Tree: Cops2

Human
homologs
COPS2, COP9 signalosome subunit 2
Orthology source: HGNC

IDs:
NCBI Gene ID: 9318
neXtProt AC: NX_P61201

Human Synonyms: ALIEN, CSN2, SGN2, TRIP15

Human Chr (Location): 15q21.2; chr15:49125274-49155657 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(15) : Gene trapped(12) Targeted(3)
 
Mice homozygous for disruptions in this gene die as embryos very soon after implantation.
 
Interactions
Cops2 interacts with 365 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (10 records)
Data Summary: Results (135)    Tissues (131)    Images (22)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 2
RNA in situ 111
Northern blot 11
Western blot 11
cDNA source data(209)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase cops2 ; ZFIN cops2    NEW 
Molecular
reagents
All nucleic(211) Genomic(1) cDNA(209) Primer pair(1)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000015340 (Evidence)
Ensembl Gene Model ENSMUSG00000027206 (Evidence)
Entrez Gene 12848 (Evidence)
UniGene 3596
DFCI TC1572317, TC1583359
NIA Mouse Gene Index U023297
Consensus CDS Project CCDS16679.1, CCDS71133.1
International Mouse Phenotyping Consortium Status Cops2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015340 VEGA Gene Model | MGI Sequence Detail 28836 C57BL/6J ±  kb
transcript OTTMUST00000036353 VEGA | MGI Sequence Detail 3392 Not Applicable 
polypeptide OTTMUSP00000016338 VEGA | MGI Sequence Detail 450 Not Applicable 

For the selected sequences
All sequences(55) RefSeq(8) UniProt(4)
Polymorphisms
RFLP(1) : SNPs within 2kb(172 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013143 PCI/PINT associated module
InterPro IPR000717 Proteasome component (PCI) domain
InterPro IPR011990 Tetratricopeptide-like helical
InterPro IPR011991 Winged helix-turn-helix DNA-binding domain
Protein Ontology PR:000005739 COP9 signalosome complex subunit 2
References
(Earliest) J:50270 Wei N, et al., The COP9 complex is conserved between plants and mammals and is related to the 26S proteasome regulatory complex. Curr Biol. 1998 Jul 30-Aug 13;8(16):919-22
(Latest) J:182258 Taher L, et al., Global gene expression analysis of murine limb development. PLoS One. 2011;6(12):e28358
All references(50)
Other
accession IDs
MGI:2138892, MGI:2139517

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory