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Ptgdr2 Gene Detail
Summary
  • Symbol
    Ptgdr2
  • Name
    prostaglandin D2 receptor 2
  • Synonyms
    Crth2, Gpr44, PGD2 receptor
  • Feature Type
    protein coding gene
  • IDs
    MGI:1330275
    NCBI Gene: 14764
  • Gene Overview
    MyGene.info: PTGDR2
Location & Maps
more
  • Sequence Map
    Chr19:10937160-10942511 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      5352 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 7.40 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    PTGDR2, prostaglandin D2 receptor 2
  • Vertebrate Orthologs
    7
  • Human Ortholog
    PTGDR2, prostaglandin D2 receptor 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CD294, CRTH2, DL1R, DP2, GPR44
  • Links
    NCBI Gene ID: 11251
    neXtProt AC: NX_Q9Y5Y4

  • Chr Location
    11q12.2; chr11:60850925-60855971 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotypes from 3 alleles in 5 genetic backgrounds
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    6
  • Gene trapped
    1
  • Targeted
    5
  • Incidental Mutations
Mice homozygous for a knock-out allele show enhanced IL-5 production and eosinophil recruitment into the lung in an allergic airway inflammatory model. In contrast, mice homozygous for a second knock-out allele exhibit lower serum IgE levels and reduced IgE-mediated inflammatory responses in skin.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000046867 VEGA Gene Model | MGI Sequence Detail 5352 C57BL/6J ±  kb
transcript OTTMUST00000121535 VEGA | MGI Sequence Detail 2644 Not Applicable  
polypeptide OTTMUSP00000066935 VEGA | MGI Sequence Detail 382 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    56 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 5
    Genomic 1
    cDNA 4

    Microarray probesets 3
Other
Accession IDs
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MGI:1336994
References
more
  • Summaries
    All 50
    Developmental Gene Expression 2
    Gene Ontology 7
    Phenotypes 22
  • Earliest
    J:49129 Mayer H, et al., Molecular characterization and tissue-specific expression of a murine putative G-protein-coupled receptor. Biochim Biophys Acta. 1998 Jul 30;1399(1):51-6
  • Latest
    J:219412 Trimarco A, et al., Prostaglandin D2 synthase/GPR44: a signaling axis in PNS myelination. Nat Neurosci. 2014 Dec;17(12):1682-92

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory