About   Help   FAQ
Zpr1 Gene Detail
Summary
  • Symbol
    Zpr1
  • Name
    ZPR1 zinc finger
  • Synonyms
    Zfp259, ZPR1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1330262
    NCBI Gene: 22687
  • Gene Overview
    MyGene.info: ZPR1
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:46273064-46282643 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 25.38 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    90 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1330262
protein coding gene Chr9:46273064-46282643 (.)
129S1/SvImJ MGP_129S1SvImJ_G0034752
protein coding gene Chr9:44905546-44913835 (+)
A/J MGP_AJ_G0034733
protein coding gene Chr9:43619807-43629456 (+)
AKR/J MGP_AKRJ_G0034660
protein coding gene Chr9:44509130-44517477 (+)
BALB/cJ MGP_BALBcJ_G0034724
protein coding gene Chr9:43340734-43350188 (+)
C3H/HeJ MGP_C3HHeJ_G0034435
protein coding gene Chr9:44982864-44994195 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035245
protein coding gene Chr9:46184948-46193412 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032159
protein coding gene Chr9:43149476-43158947 (+)
CAST/EiJ MGP_CASTEiJ_G0033757
protein coding gene Chr9:44846100-44856781 (+)
CBA/J MGP_CBAJ_G0034407
protein coding gene Chr9:47875803-47887853 (+)
DBA/2J MGP_DBA2J_G0034566
protein coding gene Chr9:43490327-43500930 (+)
FVB/NJ MGP_FVBNJ_G0034507
protein coding gene Chr9:42755177-42764452 (+)
LP/J MGP_LPJ_G0034647
protein coding gene Chr9:45223458-45231914 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034551
protein coding gene Chr9:49619188-49628647 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035266
protein coding gene Chr9:44426266-44436770 (+)
PWK/PhJ MGP_PWKPhJ_G0033462
protein coding gene Chr9:43412347-43421925 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033298
protein coding gene Chr9:44758042-44769377 (+)
WSB/EiJ MGP_WSBEiJ_G0033870
protein coding gene Chr9:44475523-44485831 (+)



Homology
more
  • Human Ortholog
    ZPR1, ZPR1 zinc finger
  • Vertebrate Orthologs
    9
  • Human Ortholog
    ZPR1, ZPR1 zinc finger
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ZNF259
  • Links
    NCBI Gene ID: 8882
    neXtProt AC: NX_O75312
    UniProt: O75312

  • Chr Location
    11q23.3; chr11:116778189-116789272 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice display embryonic lethality, fail to form a normal trophectoderm and fail to expand the inner cell mass.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 22687 NCBI Gene Model | MGI Sequence Detail 9580 C57BL/6J ±  kb
    transcript NM_011752 RefSeq | MGI Sequence Detail 2984 Not Specified  
    polypeptide Q62384 UniProt | EBI | MGI Sequence Detail 459 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 75
      cDNA 75

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2143010
    References
    more
    • Summaries
      All 37
      Developmental Gene Expression 5
      Gene Ontology 10
      Phenotypes 5
    • Earliest
      J:50499 Galcheva-Gargova Z, et al., Binding of zinc finger protein ZPR1 to the epidermal growth factor receptor. Science. 1996 Jun 21;272(5269):1797-802
    • Latest
      J:263646 Horiuchi K, et al., Impaired Spermatogenesis, Muscle, and Erythrocyte Function in U12 Intron Splicing-Defective Zrsr1 Mutant Mice. Cell Rep. 2018 Apr 3;23(1):143-155

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory