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Dpm1 Gene Detail
Summary
  • Symbol
    Dpm1
  • Name
    dolichol-phosphate (beta-D) mannosyltransferase 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1330239
    NCBI Gene: 13480
  • Gene Overview
    MyGene.info: DPM1
Location & Maps
more
  • Sequence Map
    Chr2:168209048-168230591 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      21544 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    DPM1, dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit
  • Vertebrate Orthologs
    10
  • Human Ortholog
    DPM1, dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CDGIE, MPDS
  • Links
    NCBI Gene ID: 8813
    neXtProt AC: NX_O60762

  • Chr Location
    20q13.13; chr20:50934855-50958561 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human DPM1 associations

Human Disease Mouse Models
       Congenital Disorder of Glycosylation, Type IE; CDG1E   OMIM: 608799
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016047 VEGA Gene Model | MGI Sequence Detail 21544 C57BL/6J ±  kb
transcript OTTMUST00000038290 VEGA | MGI Sequence Detail 2293 Not Applicable  
polypeptide OTTMUSP00000017164 VEGA | MGI Sequence Detail 260 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    56 from dbSNP Build 142
Protein
Information
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  • Protein Ontology
    PR:000006656 dolichol-phosphate mannosyltransferase
Molecular
Reagents
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  • All nucleic 85
    cDNA 84
    Primer pair 1

    Microarray probesets 5
Other
Accession IDs
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MGI:2138839, MGI:2138855
References
more
  • Summaries
    All 31
    Developmental Gene Expression 2
    Gene Ontology 5
    Phenotypes 6
  • Earliest
    J:50821 Tomita S, et al., A homologue of Saccharomyces cerevisiae Dpm1p is not sufficient for synthesis of dolichol-phosphate-mannose in mammalian cells. J Biol Chem. 1998 Apr 10;273(15):9249-54
  • Latest
    J:225710 Tuck E, et al., A gene expression resource generated by genome-wide lacZ profiling in the mouse. Dis Model Mech. 2015 Nov 1;8(11):1467-78

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory