Dpm1
Gene Detail

Symbol Name ID

Dpm1 dolichol-phosphate (beta-D) mannosyltransferase 1 MGI:1330239

Feature Type

protein coding gene

Genetic Map

Chromosome 2

88.46 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr2:168209048-168230591 bp, - strand From VEGA annotation of GRCm38   21544 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:2865  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: dolichyl-phosphate beta-D-mannosyltransferase
Gene Tree: Dpm1

Human homologs

Human Homolog		DPM1, dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit
NCBI Gene ID		8813
neXtProt AC		NX_O60762
Human Synonyms		CDGIE, MPDS
Human Chr (Location)		20q13.13; chr20:49551405-49575060 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human DPM1

Alleles and phenotypes

All alleles(2) : Targeted(2)

Gene Ontology (GO) classifications

All GO classifications: (21 annotations)

Process	dolichol metabolic process, GDP-mannose metabolic process, ...
Component	dolichol-phosphate-mannose synthase complex, endoplasmic reticulum, ...
Function	alcohol binding, dolichyl-phosphate beta-D-mannosyltransferase activity, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (109)    Tissues (107)    Images (15)
Theiler Stages: 2, 3, 4, 5, 22, 28

Assay Type	Results
RNA in situ	94
RT-PCR	15

cDNA source data(12)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(13) cDNA(12) Primer pair(1)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000016047 (Evidence)
Ensembl Gene Model	ENSMUSG00000078919 (Evidence)
Entrez Gene	13480 (Evidence)
DFCI	TC1576499
EC	2.4.1.83
Consensus CDS Project	CCDS17109.1
International Mouse Knockout Project Status	Dpm1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000016047	VEGA Gene Model | MGI Sequence Detail	21544	C57BL/6J
transcript	OTTMUST00000038290	VEGA | MGI Sequence Detail	2293	Not Applicable
polypeptide	OTTMUSP00000017164	VEGA | MGI Sequence Detail	260	Not Applicable

All sequences(48) RefSeq(2) UniProt(4)

Polymorphisms

SNPs(50 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001173	Glycosyl transferase, family 2
Protein Ontology	PR:000006656	dolichol-phosphate mannosyltransferase

References

(Earliest) J:50821 Tomita S, et al., A homologue of Saccharomyces cerevisiae Dpm1p is not sufficient for synthesis of dolichol-phosphate-mannose in mammalian cells. J Biol Chem. 1998 Apr 10;273(15):9249-54
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(29)

Other accession IDs

MGI:2138839, MGI:2138855