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Dpm2 Gene Detail
Summary
  • Symbol
    Dpm2
  • Name
    dolichol-phosphate (beta-D) mannosyltransferase 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1330238
    NCBI Gene: 13481
  • Gene Overview
    MyGene.info: DPM2
Location & Maps
more
  • Sequence Map
    Chr2:32570858-32573579 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      2722 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 22.09 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    DPM2, dolichyl-phosphate mannosyltransferase polypeptide 2, regulatory subunit
  • Vertebrate Orthologs
    10
  • Human Ortholog
    DPM2, dolichyl-phosphate mannosyltransferase polypeptide 2, regulatory subunit
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CDG1U
  • Links
    NCBI Gene ID: 8818
    neXtProt AC: NX_O94777

  • Chr Location
    9q34.13; chr9:127935095-127938484 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 99726
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: DPM2
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human DPM2 associations

Human Disease Mouse Models
       Congenital Disorder of Glycosylation, Type Iu; CDG1U   OMIM: 615042
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    12
  • Gene trapped
    8
  • Targeted
    4
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000011991 VEGA Gene Model | MGI Sequence Detail 2722 C57BL/6J ±  kb
transcript OTTMUST00000028376 VEGA | MGI Sequence Detail 1412 Not Applicable  
polypeptide OTTMUSP00000047627 VEGA | MGI Sequence Detail 114 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    24 from dbSNP Build 142
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000006657 dolichol phosphate-mannose biosynthesis regulatory protein
  • InterPro Domains
    IPR009914 Dolichol phosphate-mannose biosynthesis regulatory
Molecular
Reagents
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  • All nucleic 80
    cDNA 80

    Microarray probesets 4
Other
Accession IDs
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MGI:2139402, MGI:2139545
References
more
  • Summaries
    All 34
    Developmental Gene Expression 1
    Gene Ontology 8
    Phenotypes 8
  • Earliest
    J:50812 Maeda Y, et al., DPM2 regulates biosynthesis of dolichol phosphate-mannose in mammalian cells: correct subcellular localization and stabilization of DPM1, and binding of dolichol phosphate. EMBO J. 1998 Sep 1;17(17):4920-9
  • Latest
    J:142754 Hansen GM, et al., Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Genome Res. 2008 Oct;18(10):1670-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory