About   Help   FAQ
Tcap
Gene Detail
 Symbol
Name
ID
Tcap
titin-cap
MGI:1330233
Synonyms Telethonin
Feature Type protein coding gene
Genetic Map
Chromosome 11
61.75 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr11:98383811-98384953 bp, + strand
From VEGA annotation of GRCm38

  1143 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2724  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: telethonin
Gene Tree: Tcap

Human
homologs
Human Homolog TCAP, titin-cap
NCBI Gene ID 8557
neXtProt AC  NX_O15273
Human Synonyms  CMD1N, LGMD2G, T-cap, TELE, telethonin
Human Chr (Location)  17q12; chr17:39665346-39666554 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human TCAP
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
 
Mice homozygous for a knock-out allele exhibit skeletal muscle atrophy, myopathy, increased muscle stiffness, and impaired coordination. Mice homozygous for another knock-out allele exhibit increased response to transverse aortic constriction.
 
Human Diseases Modeled Using Mouse Tcap (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Tcap interacts with 82 markers (Mir15a, Mir15b, Mir16-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (25 annotations)
Process adult heart development, cardiac muscle contraction, ...
Component cytoplasm, I band, ...
Function FATZ binding, ion channel binding, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (8)    Tissues (6)    Images (3)
Theiler Stages: 15, 17
Assay TypeResults
RNA in situ 8
cDNA source data(45)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(45) cDNA(45)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000002713 (Evidence)
Ensembl Gene ModelENSMUSG00000007877 (Evidence)
Entrez Gene21393 (Evidence)
UniGene10762
DFCITC1579649, TC1595851
DoTSDT.101400890, DT.493307
NIA Mouse Gene IndexU013296
Consensus CDS ProjectCCDS25346.1
International Mouse Knockout Project StatusTcap
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000002713 VEGA Gene Model | MGI Sequence Detail 1143 C57BL/6J ±  kb
transcript OTTMUST00000005375 VEGA | MGI Sequence Detail 948 Not Applicable 
polypeptide OTTMUSP00000002542 VEGA | MGI Sequence Detail 167 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(2) UniProt(2)
Polymorphisms SNPs within 2kb(3 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR015667 Telethonin
InterPro IPR023111 Titin-like domain
Protein Ontology PR:000016156 telethonin
References (Earliest) J:51067 Gregorio CC, et al., The NH2 terminus of titin spans the Z-disc: its interaction with a novel 19-kD ligand (T-cap) is required for sarcomeric integrity. J Cell Biol. 1998 Nov 16;143(4):1013-27
(Latest) J:191122 Ibrahim M, et al., A critical role for Telethonin in regulating t-tubule structure and function in the mammalian heart. Hum Mol Genet. 2013 Jan 15;22(2):372-83
All references(36)
Disease annotation references (1)
Other
accession IDs
MGI:2144206, MGI:2144337

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/16/2014
MGI 5.19
The Jackson Laboratory