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Tcap
Gene Detail
Symbol

Name
ID
Tcap
titin-cap
MGI:1330233
Synonyms
Telethonin
Feature Type
protein coding gene
Genetic Map
Chromosome 11
61.75 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr11:98383811-98384953 bp, + strand
From VEGA annotation of GRCm38

  1143 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2724  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: TCAP
Protein SuperFamily: telethonin
Gene Tree: Tcap

Human
homologs
TCAP, titin-cap
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 8557
neXtProt AC: NX_O15273

Human Synonyms: CMD1N, CMH25, LGMD2G, T-cap, TELE, telethonin

Human Chr (Location): 17q12; chr17:39665346-39666554 (+)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human TCAP

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Genomic Mutations involving Tcap (1)
 
Mice homozygous for a knock-out allele exhibit skeletal muscle atrophy, myopathy, increased muscle stiffness, and impaired coordination. Mice homozygous for another knock-out allele exhibit increased response to transverse aortic constriction.
 
Human Diseases Modeled in Mice Using Tcap (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Tcap interacts with 82 markers (Mir15a, Mir15b, Mir16-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (26 annotations)
Process adult heart development, cardiac muscle contraction, ...
Component cytoplasm, I band, ...
Function BMP binding, FATZ binding, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (8)    Tissues (6)    Images (3)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 8
cDNA source data(45)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase tcap    NEW 
Molecular
reagents
All nucleic(45) cDNA(45)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000002713 (Evidence)
Ensembl Gene Model ENSMUSG00000007877 (Evidence)
Entrez Gene 21393 (Evidence)
UniGene 10762
DFCI TC1579649, TC1595851
DoTS DT.101400890, DT.493307
NIA Mouse Gene Index U013296
Consensus CDS Project CCDS25346.1
International Mouse Phenotyping Consortium Status Tcap
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000002713 VEGA Gene Model | MGI Sequence Detail 1143 C57BL/6J ±  kb
transcript OTTMUST00000005375 VEGA | MGI Sequence Detail 948 Not Applicable 
polypeptide OTTMUSP00000002542 VEGA | MGI Sequence Detail 167 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(3 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR015667 Telethonin
InterPro IPR023111 Titin-like domain
Protein Ontology PR:000016156 telethonin
References
(Earliest) J:51067 Gregorio CC, et al., The NH2 terminus of titin spans the Z-disc: its interaction with a novel 19-kD ligand (T-cap) is required for sarcomeric integrity. J Cell Biol. 1998 Nov 16;143(4):1013-27
(Latest) J:218985 Podobed PS, et al., Circadian regulation of myocardial sarcomeric Titin-cap (Tcap, telethonin): identification of cardiac clock-controlled genes using open access bioinformatics data. PLoS One. 2014;9(8):e104907
All references(36)
Disease annotation references (1)
Other
accession IDs
MGI:2144206, MGI:2144337

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/30/2015
MGI 5.22
The Jackson Laboratory