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Papss2
Gene Detail
Symbol

Name
ID
Papss2
3'-phosphoadenosine 5'-phosphosulfate synthase 2
MGI:1330223
Synonyms
1810018P12Rik, Atpsk2, Sk2
Feature Type
protein coding gene
Genetic Map
Chromosome 19
27.46 cM
Detailed Genetic Map ± 1 cM


Mapping data(29)
Sequence Map
Chr19:32620005-32667187 bp, + strand
From Ensembl annotation of GRCm38

  47183 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55840  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: PAPSS2
Gene Tree: Papss2

Human
homologs
PAPSS2, 3'-phosphoadenosine 5'-phosphosulfate synthase 2
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 9060
neXtProt AC: NX_O95340

Human Synonyms: ATPSK2, BCYM4, SK2

Human Chr (Location): 10q24; chr10:87659719-87747705 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human PAPSS2

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(2) Spontaneous(1) Targeted(2)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for mutation s in this gene display delayed growth and shorter limbs and other abnormalities in bone formation.
 
Human Diseases Modeled in Mice Using Papss2 (1)    Mutations Annotated to Human Diseases (1)    Phenotype Images(1)
Interactions
Papss2 interacts with 251 markers (Mir10a, Mir10b, Mir15a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process, blood coagulation, ...
Function adenylylsulfate kinase activity, ATP binding, ...
External Resources: FuncBase
Expression
Literature Summary: (10 records)
Data Summary: Results (518)    Tissues (294)    Images (68)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 501
RT-PCR 17
cDNA source data(66)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA PAPSS2 ; Xenbase papss2 ; ZFIN papss2b    NEW 
Molecular
reagents
All nucleic(75) Genomic(2) cDNA(66) Primer pair(6) Other(1)
Microarray probesets(6)
Other database
links
Ensembl Gene Model ENSMUSG00000024899 (Evidence)
Entrez Gene 23972 (Evidence)
UniGene 203916
DFCI TC1579822, TC1679078, TC1623474, TC1598103
DoTS DT.91366198, DT.493334, DT.91303059, DT.111150560, DT.101718472
NIA Mouse Gene Index U044000, U038971
EC 2.7.7.4, 2.7.1.25
Consensus CDS Project CCDS37960.1
International Mouse Phenotyping Consortium Status Papss2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024899 Ensembl Gene Model | MGI Sequence Detail 47183 C57BL/6J ±  kb
transcript ENSMUST00000025833 Ensembl | MGI Sequence Detail 3635 Not Applicable 
polypeptide ENSMUSP00000025833 Ensembl | MGI Sequence Detail 621 Not Applicable 

For the selected sequences
All sequences(45) RefSeq(8) UniProt(1)
Polymorphisms
PCR(1) : SNPs within 2kb(678 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002891 Adenylylsulphate kinase
InterPro IPR025980 ATP-sulfurylase PUA-like domain
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR015947 PUA-like domain
InterPro IPR014729 Rossmann-like alpha/beta/alpha sandwich fold
InterPro IPR002650 Sulphate adenylyltransferase
InterPro IPR024951 Sulphate adenylyltransferase catalytic domain
Protein Ontology PR:000012274 bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2
References
(Earliest) J:5109 Lane PW, et al., Three recessive mutations producing disproportionate dwarfing in mice: achondroplasia, brachymorphic, and stubby. J Hered. 1968 Sep-Oct;59(5):300-8
(Latest) J:194247 Hudson BH, et al., Role for cytoplasmic nucleotide hydrolysis in hepatic function and protein synthesis. Proc Natl Acad Sci U S A. 2013 Mar 26;110(13):5040-5
All references(79)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-1582, MGI:1921420, MGI:2147481, MGI:88171

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory