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Cldn3 Gene Detail
Summary
  • Symbol
    Cldn3
  • Name
    claudin 3
  • Synonyms
    Cpetr2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1329044
    NCBI Gene: 12739
  • Gene Overview
    MyGene.info: CLDN3
Location & Maps
more
  • Sequence Map
    Chr5:134986214-134987472 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      1259 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 74.93 cM
  • Mapping Data
    9 experiments
Homology
more
  • Human Ortholog
    CLDN3, claudin 3
  • Vertebrate Orthologs
    13
  • Human Ortholog
    CLDN3, claudin 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    C7orf1, CPE-R2, CPETR2, HRVP1, RVP1
  • Links
    NCBI Gene ID: 1365
    neXtProt AC: NX_O15551

  • Chr Location
    7q11.23; chr7:73768997-73770270 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 1001
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;3 zebrafish;2 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: CLDN3
  • Gene Tree
Human Diseases
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  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    5 phenotype references
  • All Mutations and Alleles
    3
  • Targeted
    3
  • Genomic Mutations
    2 involving Cldn3
Mice homozygous for a null allele are fertile with mutant males exhibiting normal spermatogenesis and fully functional Sertoli cell tight junctions.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022612 VEGA Gene Model | MGI Sequence Detail 1259 C57BL/6J ±  kb
transcript OTTMUST00000054156 VEGA | MGI Sequence Detail 1259 Not Applicable  
polypeptide OTTMUSP00000025806 VEGA | MGI Sequence Detail 219 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    20 from dbSNP Build 142
  • PCR
Protein
Information
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Molecular
Reagents
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  • All nucleic 24
    Genomic 4
    cDNA 16
    Primer pair 4

    Microarray probesets 6
Other
Accession IDs
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MGI:2140814
References
more
  • Summaries
    All 69
    Developmental Gene Expression 28
    Diseases 3
    Gene Ontology 12
    Phenotypes 5
  • Earliest
    J:52002 Paperna T, et al., Genes for the CPE receptor (CPETR1) and the human homolog of RVP1 (CPETR2) are localized within the Williams-Beuren syndrome deletion. Genomics. 1998 Dec 15;54(3):453-9
  • Latest
    J:233398 Wu RC, et al., Androgen Receptor Coactivator ARID4B Is Required for the Function of Sertoli Cells in Spermatogenesis. Mol Endocrinol. 2015 Sep;29(9):1334-46

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory