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Cldn3 Gene Detail
Summary
  • Symbol
    Cldn3
  • Name
    claudin 3
  • Synonyms
    Cpetr2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1329044
    NCBI Gene: 12739
  • Gene Overview
    MyGene.info: CLDN3
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:134986214-134987472 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 74.93 cM
  • Mapping Data
    9 experiments
Strain
Comparison
more
  • SNPs within 2kb
    20 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1329044
protein coding gene Chr5:134986214-134987476 (.)
129S1/SvImJ MGP_129S1SvImJ_G0030168
protein coding gene Chr5:139458084-139459342 (+)
A/J MGP_AJ_G0030136
protein coding gene Chr5:133510218-133511476 (+)
AKR/J MGP_AKRJ_G0030069
protein coding gene Chr5:137849026-137850284 (+)
BALB/cJ MGP_BALBcJ_G0030146
protein coding gene Chr5:134864349-134865607 (+)
C3H/HeJ MGP_C3HHeJ_G0029862
protein coding gene Chr5:138409923-138411181 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030599
protein coding gene Chr5:144695816-144697074 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027822
protein coding gene Chr5:127808284-127809547 (+)
CAST/EiJ MGP_CASTEiJ_G0029271
protein coding gene Chr5:137837990-137839248 (+)
CBA/J MGP_CBAJ_G0029832
protein coding gene Chr5:150345336-150346594 (+)
DBA/2J MGP_DBA2J_G0029983
protein coding gene Chr5:133405174-133406432 (+)
FVB/NJ MGP_FVBNJ_G0029938
protein coding gene Chr5:132538699-132539957 (+)
LP/J MGP_LPJ_G0030071
protein coding gene Chr5:139917319-139918577 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029970
protein coding gene Chr5:153364907-153366165 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030639
protein coding gene Chr5:137592302-137593560 (+)
PWK/PhJ MGP_PWKPhJ_G0028986
protein coding gene Chr5:132451750-132453008 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028821
protein coding gene Chr5:135156744-135158002 (+)
WSB/EiJ MGP_WSBEiJ_G0029345
protein coding gene Chr5:138343806-138345064 (+)



Homology
more
  • Human Ortholog
    CLDN3, claudin 3
  • Vertebrate Orthologs
    13
  • Human Ortholog
    CLDN3, claudin 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    C7orf1, CPE-R2, CPETR2, HRVP1, RVP1
  • Links
    NCBI Gene ID: 1365
    neXtProt AC: NX_O15551
    UniProt: O15551

  • Chr Location
    7q11.23; chr7:73768997-73770270 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 1001
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;3 zebrafish;2 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: CLDN3
  • Gene Tree
Human Diseases
less
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    6 phenotype references
Mice homozygous for a null allele are fertile with mutant males exhibiting normal spermatogenesis and fully functional Sertoli cell tight junctions.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000070473 Ensembl Gene Model | MGI Sequence Detail 1259 C57BL/6J ±  kb
transcript ENSMUST00000094245 Ensembl | MGI Sequence Detail 1259 Not Applicable  
polypeptide ENSMUSP00000091799 Ensembl | MGI Sequence Detail 219 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 26
    Genomic 4
    cDNA 17
    Primer pair 4
    Other 1

    Microarray probesets 6
Other
Accession IDs
less
MGI:2140814
References
more
  • Summaries
    All 83
    Developmental Gene Expression 32
    Diseases 2
    Gene Ontology 14
    Phenotypes 6
  • Earliest
    J:43620 Katahira J, et al., Clostridium perfringens enterotoxin utilizes two structurally related membrane proteins as functional receptors in vivo. J Biol Chem. 1997 Oct 17;272(42):26652-8
  • Latest
    J:265031 Sequeira I, et al., Immunomodulatory role of Keratin 76 in oral and gastric cancer. Nat Commun. 2018 Aug 24;9(1):3437

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory