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Ccl17 Gene Detail
Summary
  • Symbol
    Ccl17
  • Name
    chemokine (C-C motif) ligand 17
  • Synonyms
    ABCD-2, Scya17, TARC
  • Feature Type
    protein coding gene
  • IDs
    MGI:1329039
    NCBI Gene: 20295
  • Gene Overview
    MyGene.info: CCL17
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:94810453-94812036 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 46.85 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    32 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1329039
protein coding gene Chr8:94805250-94812038 (.)
129S1/SvImJ MGP_129S1SvImJ_G0033969
protein coding gene Chr8:96245314-96246896 (+)
A/J MGP_AJ_G0033952
protein coding gene Chr8:92499392-92500974 (+)
AKR/J MGP_AKRJ_G0033878
protein coding gene Chr8:95017617-95019199 (+)
BALB/cJ MGP_BALBcJ_G0033944
protein coding gene Chr8:92579038-92580620 (+)
C3H/HeJ MGP_C3HHeJ_G0033654
protein coding gene Chr8:95730534-95732116 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034465
protein coding gene Chr8:99748076-99749658 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031406
protein coding gene Chr8:86302645-86304212 (+)
CAST/EiJ MGP_CASTEiJ_G0032986
protein coding gene Chr8:95332954-95334536 (+)
CBA/J MGP_CBAJ_G0033630
protein coding gene Chr8:103040273-103041855 (+)
DBA/2J MGP_DBA2J_G0033784
protein coding gene Chr8:91956805-91958387 (+)
FVB/NJ MGP_FVBNJ_G0033731
protein coding gene Chr8:90924586-90926168 (+)
LP/J MGP_LPJ_G0033876
protein coding gene Chr8:96394952-96396534 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033773
protein coding gene Chr8:105337762-105339344 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034483
protein coding gene Chr8:95184494-95186076 (+)
PWK/PhJ MGP_PWKPhJ_G0032688
protein coding gene Chr8:91345088-91346670 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032525
protein coding gene Chr8:94018860-94020456 (+)
WSB/EiJ MGP_WSBEiJ_G0033098
protein coding gene Chr8:95715344-95716926 (+)



Homology
more
  • Human Ortholog
    CCL17, C-C motif chemokine ligand 17
  • Vertebrate Orthologs
    7
  • Human Ortholog
    CCL17, C-C motif chemokine ligand 17
    Orthology source: HomoloGene, HGNC
  • Synonyms
    A-152E5.3, ABCD-2, SCYA17, TARC
  • Links
    NCBI Gene ID: 6361
    neXtProt AC: NX_Q92583
    UniProt: Q92583

  • Chr Location
    16q21; chr16:57396076-57416063 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    6 phenotypes from multigenic genotypes
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit decreased contact hypersensitivity and increased allograft survival.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000031780 Ensembl Gene Model | MGI Sequence Detail 1584 C57BL/6J ±  kb
transcript ENSMUST00000034232 Ensembl | MGI Sequence Detail 514 Not Applicable  
polypeptide ENSMUSP00000034232 Ensembl | MGI Sequence Detail 103 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    3 Sequences
  • InterPro Domains
    IPR000827 CC chemokine, conserved site
    IPR001811 Chemokine interleukin-8-like domain
    IPR036048 Chemokine interleukin-8-like superfamily
Molecular
Reagents
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  • All nucleic 10
    cDNA 9
    Primer pair 1

    Microarray probesets 3
References
more
  • Summaries
    All 60
    Developmental Gene Expression 6
    Gene Ontology 5
    Phenotypes 16
  • Earliest
    J:51316 Yoneyama H, et al., Pivotal role of TARC, a CC chemokine, in bacteria-induced fulminant hepatic failure in mice. J Clin Invest. 1998 Dec 1;102(11):1933-41
  • Latest
    J:265225 Saleh R, et al., CSF-1 in Inflammatory and Arthritic Pain Development. J Immunol. 2018 Oct 1;201(7):2042-2053

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory