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Ccl17 Gene Detail
Summary
  • Symbol
    Ccl17
  • Name
    chemokine (C-C motif) ligand 17
  • Synonyms
    ABCD-2, Scya17, TARC
  • Feature Type
    protein coding gene
  • IDs
    MGI:1329039
    NCBI Gene: 20295
  • Gene Overview
    MyGene.info: CCL17
Location & Maps
more
  • Sequence Map
    Chr8:94810453-94812035 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      1583 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 46.85 cM
  • Detailed Genetic Map ± 1 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    CCL17, C-C motif chemokine ligand 17
  • Vertebrate Orthologs
    7
  • Human Ortholog
    CCL17, C-C motif chemokine ligand 17
    Orthology source: HGNC, HomoloGene
  • Synonyms
    A-152E5.3, ABCD-2, SCYA17, TARC
  • Links
    NCBI Gene ID: 6361
    neXtProt AC: NX_Q92583

  • Chr Location
    16q13; chr16:57396190-57416063 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    6 phenotypes from multigenic genotypes
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    5
  • Gene trapped
    1
  • Targeted
    4
Mice homozygous for a knock-out allele exhibit decreased contact hypersensitivity and increased allograft survival.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000031780 Ensembl Gene Model | MGI Sequence Detail 1583 C57BL/6J ±  kb
transcript ENSMUST00000034232 Ensembl | MGI Sequence Detail 513 Not Applicable  
polypeptide ENSMUSP00000034232 Ensembl | MGI Sequence Detail 103 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    32 from dbSNP Build 142
Protein
Information
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  • UniProt
    3 Sequences
  • InterPro Domains
    IPR000827 CC chemokine, conserved site
    IPR001811 Chemokine interleukin-8-like domain
Molecular
Reagents
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  • All nucleic 9
    cDNA 8
    Primer pair 1

    Microarray probesets 3
References
more
  • Summaries
    All 44
    Developmental Gene Expression 5
    Gene Ontology 4
    Phenotypes 12
  • Earliest
    J:51316 Yoneyama H, et al., Pivotal role of TARC, a CC chemokine, in bacteria-induced fulminant hepatic failure in mice. J Clin Invest. 1998 Dec 1;102(11):1933-41
  • Latest
    J:208732 Globisch T, et al., Cytokine-dependent regulation of dendritic cell differentiation in the splenic microenvironment. Eur J Immunol. 2014 Feb;44(2):500-10

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/24/2016
MGI 6.04
The Jackson Laboratory