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Mllt10 Gene Detail
Summary
  • Symbol
    Mllt10
  • Name
    myeloid/lymphoid or mixed-lineage leukemia; translocated to, 10
  • Synonyms
    Af10, B130021D15Rik, D630001B22Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1329038
    NCBI Gene: 17354
  • Gene Overview
    MyGene.info: MLLT10
  • Alliance
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:18055237-18212388 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 12.84 cM, cytoband A2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    300 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1329038
protein coding gene Chr2:18055175-18212390 (.)
129S1/SvImJ MGP_129S1SvImJ_G0025373
protein coding gene Chr2:15724226-15900317 (+)
A/J MGP_AJ_G0025351
protein coding gene Chr2:15094959-15271850 (+)
AKR/J MGP_AKRJ_G0025319
protein coding gene Chr2:15597175-15765950 (+)
BALB/cJ MGP_BALBcJ_G0025346
protein coding gene Chr2:15124956-15286699 (+)
C3H/HeJ MGP_C3HHeJ_G0025106
protein coding gene Chr2:15504832-15672325 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025789
protein coding gene Chr2:16100551-16290758 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023204
protein coding gene Chr2:14524334-14681870 (+)
CAST/EiJ MGP_CASTEiJ_G0024570
protein coding gene Chr2:15472610-15644823 (+)
CBA/J MGP_CBAJ_G0025085
protein coding gene Chr2:16840392-17030883 (+)
DBA/2J MGP_DBA2J_G0025217
protein coding gene Chr2:15025648-15186941 (+)
FVB/NJ MGP_FVBNJ_G0025180
protein coding gene Chr2:14831710-14990248 (+)
LP/J MGP_LPJ_G0025304
protein coding gene Chr2:15598143-15769098 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025211
protein coding gene Chr2:16779304-16974993 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025847
protein coding gene Chr2:15532329-15702390 (+)
PWK/PhJ MGP_PWKPhJ_G0024319
protein coding gene Chr2:14881761-15039611 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024119
protein coding gene Chr2:15653724-15820523 (+)
WSB/EiJ MGP_WSBEiJ_G0024640
protein coding gene Chr2:15629760-15796671 (+)



Homology
more
  • Human Ortholog
    MLLT10, MLLT10, histone lysine methyltransferase DOT1L cofactor
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MLLT10, MLLT10, histone lysine methyltransferase DOT1L cofactor
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AF10
  • Links
    NCBI Gene ID: 8028
    neXtProt AC: NX_P55197
    UniProt: P55197

  • Chr Location
    10p12.31; chr10:21533349-21743630 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 20973
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: MLLT10
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human MLLT10 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000026743 Ensembl Gene Model | MGI Sequence Detail 157152 C57BL/6J ±  kb
transcript ENSMUST00000114680 Ensembl | MGI Sequence Detail 3543 Not Applicable  
polypeptide ENSMUSP00000110328 Ensembl | MGI Sequence Detail 1068 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 25
    Genomic 2
    cDNA 22
    Primer pair 1

    Microarray probesets 6
Other
Accession IDs
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MGI:2443668, MGI:2443937
References
more
  • Summaries
    All 39
    Developmental Gene Expression 5
    Gene Ontology 4
    Phenotypes 10
  • Earliest
    J:51922 Linder B, et al., Expression pattern and cellular distribution of the murine homologue of AF10. Biochim Biophys Acta. 1998 Dec 22;1443(3):285-96
  • Latest
    J:256374 Ogoh H, et al., Mllt10 knockout mouse model reveals critical role of Af10-dependent H3K79 methylation in midfacial development. Sci Rep. 2017 Sep 20;7(1):11922

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory