Mllt10
Gene Detail

Symbol Name ID

Mllt10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 MGI:1329038

Synonyms

Af10, B130021D15Rik, D630001B22Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 2

12.84 cM, cytoband A2
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr2:18064394-18212388 bp, + strand From VEGA annotation of GRCm38   147995 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:20973  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Mllt10

Human homologs

Human Homolog		MLLT10, myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
NCBI Gene ID		8028
neXtProt AC		NX_P55197
Human Synonyms		AF10
Human Chr (Location)		10p12; chr10:21823101-22032559 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human MLLT10

Alleles and phenotypes

All alleles(141) : Targeted(4) Gene trapped(137)

Gene Ontology (GO) classifications

All GO classifications: (5 annotations)

Process	positive regulation of transcription from RNA polymerase II promoter
Component	cytoplasm, nucleus
Function	metal ion binding, zinc ion binding

External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (74)    Tissues (72)    Images (5)
Theiler Stages: 2, 3, 4, 5, 15, 17, 19, 21, 23, 28

Assay Type	Results
RNA in situ	59
RT-PCR	15

cDNA source data(21)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(24) Genomic(2) cDNA(21) Primer pair(1)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000011456 (Evidence)
Ensembl Gene Model	ENSMUSG00000026743 (Evidence)
Entrez Gene	17354 (Evidence)
Consensus CDS Project	CCDS15708.1, CCDS57155.1
International Mouse Knockout Project Status	Mllt10

Sequences

Length	Strain/Species
genomic	OTTMUSG00000011456	VEGA Gene Model | MGI Sequence Detail	147995	C57BL/6J
transcript	OTTMUST00000026949	VEGA | MGI Sequence Detail	3543	Not Applicable
polypeptide	OTTMUSP00000012295	VEGA | MGI Sequence Detail	1068	Not Applicable

All sequences(66) RefSeq(8) UniProt(6)

Polymorphisms

SNPs(271 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR011011	Zinc finger, FYVE/PHD-type
InterPro	IPR019787	Zinc finger, PHD-finger
InterPro	IPR001965	Zinc finger, PHD-type
InterPro	IPR019786	Zinc finger, PHD-type, conserved site
InterPro	IPR013083	Zinc finger, RING/FYVE/PHD-type
Protein Ontology	PR:000010450	protein AF-10

References

(Earliest) J:51922 Linder B, et al., Expression pattern and cellular distribution of the murine homologue of AF10. Biochim Biophys Acta. 1998 Dec 22;1443(3):285-96
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(36)

Other accession IDs

MGI:2443668, MGI:2443937