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Ggh
Gene Detail
Symbol

Name
ID
Ggh
gamma-glutamyl hydrolase
MGI:1329035
Synonyms
gamma-GH
Feature Type
protein coding gene
Genetic Map
Chromosome 4
7.79 cM, cytoband A3-A5
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr4:20042052-20066750 bp, + strand
From VEGA annotation of GRCm38

  24699 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2881  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: GGH
Protein SuperFamily: Gamma-glutamyl hydrolase
Gene Tree: Ggh

Human
homologs
GGH, gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 8836
neXtProt AC: NX_Q92820

Human Synonyms: GH

Human Chr (Location): 8q12.3; chr8:63015079-63039445 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(1) : Targeted(1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
Interactions
Ggh interacts with 156 markers (Mir1b, Mir7-1, Mir15b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process glutamine metabolic process, proteolysis, ...
Component cytosol, extracellular exosome, ...
Function catalytic activity, gamma-glutamyl-peptidase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (94)    Tissues (94)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 94
cDNA source data(42)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase ggh    NEW 
Molecular
reagents
All nucleic(43) Genomic(1) cDNA(42)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000006380 (Evidence)
Ensembl Gene Model ENSMUSG00000073987 (Evidence)
Entrez Gene 14590 (Evidence)
UniGene 20461
DFCI TC1578528
NIA Mouse Gene Index U004115
EC 3.4.19.9
Consensus CDS Project CCDS51126.1
International Mouse Phenotyping Consortium Status Ggh
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006380 VEGA Gene Model | MGI Sequence Detail 24699 C57BL/6J ±  kb
transcript OTTMUST00000014510 VEGA | MGI Sequence Detail 1965 Not Applicable 
polypeptide OTTMUSP00000006742 VEGA | MGI Sequence Detail 317 Not Applicable 

For the selected sequences
All sequences(35) RefSeq(4) UniProt(3)
Polymorphisms
SNPs within 2kb(402 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011697 Peptidase C26
InterPro IPR015527 Peptidase C26, gamma-glutamyl hydrolase
Protein Ontology PR:000007957 gamma-glutamyl hydrolase
References
(Earliest) J:50477 Esaki T, et al., Cloning of mouse gamma-glutamyl hydrolase in the form of two cDNA variants with different 5' ends and encoding alternate leader peptide sequences. Gene. 1998 Sep 28;219(1-2):37-44
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(29)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory