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Ccne2 Gene Detail
Summary
  • Symbol
    Ccne2
  • Name
    cyclin E2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1329034
    NCBI Gene: 12448
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr4:11191351-11204779 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      13429 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 5.07 cM, cytoband A2
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    CCNE2, cyclin E2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CCNE2, cyclin E2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CYCE2
  • Links
    NCBI Gene ID: 9134
    neXtProt AC: NX_O96020
    UniProt: O96020

  • Chr Location
    8q22.1; chr8:94880224-94896671 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 2 alleles in 2 genetic backgrounds
    32 phenotypes from multigenic genotypes
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Female mice homozygous for disruptions in this gene are phenotypically normal. Male mice show reduced fertility but are otherwise normal.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000004537 VEGA Gene Model | MGI Sequence Detail 13429 C57BL/6J ±  kb
    transcript OTTMUST00000010276 VEGA | MGI Sequence Detail 2908 Not Applicable  
    polypeptide OTTMUSP00000004879 VEGA | MGI Sequence Detail 404 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      78 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 16
      Genomic 1
      cDNA 14
      Primer pair 1

      Microarray probesets 4
    References
    more
    • Summaries
      All 71
      Developmental Gene Expression 22
      Gene Ontology 7
      Phenotypes 14
    • Earliest
      J:24521 Hirai H, et al., Novel INK4 proteins, p19 and p18, are specific inhibitors of the cyclin D-dependent kinases CDK4 and CDK6. Mol Cell Biol. 1995 May;15(5):2672-81
    • Latest
      J:257896 Huang W, et al., Loss of microRNA-128 promotes cardiomyocyte proliferation and heart regeneration. Nat Commun. 2018 Feb 16;9(1):700

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory