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Ccne2
Gene Detail
Symbol

Name
ID
Ccne2
cyclin E2
MGI:1329034
Feature Type
protein coding gene
Genetic Map
Chromosome 4
5.07 cM, cytoband A2
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr4:11191351-11204779 bp, + strand
From VEGA annotation of GRCm38

  13429 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7660  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: CCNE2
Protein SuperFamily: cyclin, A/B/D/E types
Gene Tree: Ccne2

Human
homologs
CCNE2, cyclin E2
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 9134
neXtProt AC: NX_O96020

Human Synonyms: CYCE2

Human Chr (Location): 8q22.1; chr8:94880224-94896653 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(4) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Female mice homozygous for disruptions in this gene are phenotypically normal. Male mice show reduced fertility but are otherwise normal.
 
Interactions
Ccne2 interacts with 253 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process cell cycle, cell division, ...
Component nucleus
Function cyclin-dependent protein serine/threonine kinase regulator activity, protein kinase binding
External Resources: FuncBase
Expression
Literature Summary: (21 records)
Data Summary: Results (67)    Tissues (60)    Images (9)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 4
RNA in situ 62
RT-PCR 1
cDNA source data(14)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase ccne2    NEW 
Molecular
reagents
All nucleic(16) Genomic(1) cDNA(14) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000004537 (Evidence)
Ensembl Gene Model ENSMUSG00000028212 (Evidence)
Entrez Gene 12448 (Evidence)
Consensus CDS Project CCDS17965.1, CCDS17966.1
International Mouse Phenotyping Consortium Status Ccne2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000004537 VEGA Gene Model | MGI Sequence Detail 13429 C57BL/6J ±  kb
transcript OTTMUST00000010276 VEGA | MGI Sequence Detail 2908 Not Applicable 
polypeptide OTTMUSP00000004879 VEGA | MGI Sequence Detail 404 Not Applicable 

For the selected sequences
All sequences(50) RefSeq(14) UniProt(5)
Polymorphisms
SNPs within 2kb(75 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004367 Cyclin, C-terminal domain
InterPro IPR013763 Cyclin-like
InterPro IPR006671 Cyclin, N-terminal
Protein Ontology PR:000005126 G1/S-specific cyclin-E2
References
(Earliest) J:51317 Lauper N, et al., Cyclin E2: a novel CDK2 partner in the late G1 and S phases of the mammalian cell cycle. Oncogene. 1998 Nov 19;17(20):2637-43
(Latest) J:220960 Akiyama R, et al., Sall4-Gli3 system in early limb progenitors is essential for the development of limb skeletal elements. Proc Natl Acad Sci U S A. 2015 Apr 21;112(16):5075-80
All references(58)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/30/2015
MGI 5.22
The Jackson Laboratory