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Agxt Gene Detail
Summary
  • Symbol
    Agxt
  • Name
    alanine-glyoxylate aminotransferase
  • Synonyms
    Agt1, Agxt1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1329033
    NCBI Gene: 11611
Location & Maps
more
  • Sequence Map
    Chr1:93135240-93145421 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      10182 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    AGXT, alanine-glyoxylate aminotransferase
  • Vertebrate Orthologs
    12
  • Human Ortholog
    AGXT, alanine-glyoxylate aminotransferase
    Orthology source: HGNC, HomoloGene
  • Synonyms
    AGT, AGT1, AGXT1, PH1, SPAT, SPT, TLH6
  • Links
    NCBI Gene ID: 189
    neXtProt AC: NX_P21549

  • Chr Location
    2q37.3; chr2:240868745-240879119 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Agxt mouse models; 1 with human AGXT associations

Human Disease Mouse Models
       Hyperoxaluria, Primary, Type I; HP1   OMIM: 259900 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 1 allele in 2 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    4
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Targeted
    2
  • Genomic Mutations
    2 involving Agxt
  • Incidental Mutations
Mice homozygous for a null allele exhibit increased urinary oxalate levels and male mice suffer from bladder stones.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000048639 VEGA Gene Model | MGI Sequence Detail 10182 C57BL/6J ±  kb
transcript OTTMUST00000124577 VEGA | MGI Sequence Detail 1553 Not Applicable  
polypeptide OTTMUSP00000067759 VEGA | MGI Sequence Detail 414 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    83 from dbSNP Build 137
  • PCR
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000030629 serine--pyruvate aminotransferase
  • PDB
  • EC
  • InterPro Domains
    IPR000192 Aminotransferase class V domain
    IPR020578 Aminotransferase class-V, pyridoxal-phosphate binding site
    IPR015424 Pyridoxal phosphate-dependent transferase
    IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1
    IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2
    IPR024169 Serine-pyruvate aminotransferase/2-aminoethylphosphonate-pyruvate transaminase
Molecular
Reagents
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  • All nucleic 51
    Genomic 1
    cDNA 48
    Primer pair 2

    Microarray probesets 3
References
more
  • Summaries
    All 29
    Developmental Gene Expression 2
    Diseases 1
    Gene Ontology 8
    Phenotypes 9
  • Earliest
    J:117428 Danpure CJ, et al., Evolution of alanine:glyoxylate aminotransferase 1 peroxisomal and mitochondrial targeting. A survey of its subcellular distribution in the livers of various representatives of the classes Mammalia, Aves and Amphibia. Eur J Cell Biol. 1994 Aug;64(2):295-313
  • Latest
    J:218171 Falix FA, et al., Hepatic Notch2 deficiency leads to bile duct agenesis perinatally and secondary bile duct formation after weaning. Dev Biol. 2014 Dec 15;396(2):201-13

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory