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Agxt
Gene Detail
 Symbol
Name
ID
Agxt
alanine-glyoxylate aminotransferase
MGI:1329033
Synonyms Agt1, Agxt1
Feature Type protein coding gene
Genetic Map
Chromosome 1
47.00 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr1:93135276-93145421 bp, + strand
From NCBI annotation of GRCm38

  10146 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37251  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 2 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: serine--pyruvate aminotransferase
Gene Tree: Agxt

Human
homologs
Human Homolog AGXT, alanine-glyoxylate aminotransferase
NCBI Gene ID 189
neXtProt AC  NX_P21549
Human Synonyms  AGT, AGT1, AGXT1, PH1, SPAT, SPT, TLH6
Human Chr (Location)  2q37.3; chr2:240868745-240879119 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human AGXT
Alleles
and
phenotypes
All alleles(2) : Targeted(2)
 
Mice homozygous for a null allele exhibit increased urinary oxalate levels and male mice suffer from bladder stones.
 
Human Diseases Modeled Using Mouse Agxt (1)    Alleles Annotated to Human Diseases(1)   
Gene Ontology
(GO)
classifications
All GO classifications: (32 annotations)
Process glycine biosynthetic process, by transamination of glyoxylate, glyoxylate catabolic process, ...
Component mitochondrial matrix, mitochondrion, ...
Function alanine-glyoxylate transaminase activity, amino acid binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (107)    Tissues (106)   
Theiler Stages: 22, 23, 28
Assay TypeResults
RNA in situ 94
Northern blot 12
RNase protection 1
cDNA source data(48)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(51) Genomic(1) cDNA(48) Primer pair(2)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000026272 (Evidence)
Entrez Gene11611 (Evidence)
UniGene7457
DFCITC1581591
DoTSDT.531734, DT.97400786
NIA Mouse Gene IndexU000625
EC2.6.1.44, 2.6.1.51
PDB3KGW, 3KGX
Consensus CDS ProjectCCDS15184.1
International Mouse Knockout Project StatusAgxt
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 11611 NCBI Gene Model | MGI Sequence Detail 10146 C57BL/6J ±  kb
transcript NM_016702 RefSeq | MGI Sequence Detail 1553 C57BL/6 
polypeptide O35423 UniProt | EBI | MGI Sequence Detail 414 Not Applicable 

For the selected sequences
All sequences(19) RefSeq(4) UniProt(2)
Polymorphisms PCR(1) : SNPs within 2kb(83 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000192 Aminotransferase, class V/Cysteine desulfurase
InterPro IPR020578 Aminotransferase class-V pyridoxal-phosphate binding site
InterPro IPR015424 Pyridoxal phosphate-dependent transferase
InterPro IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1
InterPro IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2
InterPro IPR024169 Serine-pyruvate aminotransferase/2-aminoethylphosphonate-pyruvate transaminase
Protein Ontology PR:000030629 serine--pyruvate aminotransferase, mitochondrial
Graphical View of Protein Domain Structure
References (Earliest) J:117428 Danpure CJ, et al., Evolution of alanine:glyoxylate aminotransferase 1 peroxisomal and mitochondrial targeting. A survey of its subcellular distribution in the livers of various representatives of the classes Mammalia, Aves and Amphibia. Eur J Cell Biol. 1994 Aug;64(2):295-313
(Latest) J:181969 Knight J, et al., Hydroxyproline metabolism in mouse models of primary hyperoxaluria. Am J Physiol Renal Physiol. 2012 Mar;302(6):F688-93
All references(31)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory