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Agxt
Gene Detail
Symbol

Name
ID
Agxt
alanine-glyoxylate aminotransferase
MGI:1329033
Synonyms
Agt1, Agxt1
Feature Type
protein coding gene
Genetic Map
Chromosome 1
47.00 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr1:93135240-93145421 bp, + strand
From VEGA annotation of GRCm38

  10182 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37251  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 2 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: AGXT
Protein SuperFamily: serine--pyruvate aminotransferase
Gene Tree: Agxt

Human
homologs
AGXT, alanine-glyoxylate aminotransferase
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 189
neXtProt AC: NX_P21549

Human Synonyms: AGT, AGT1, AGXT1, PH1, SPAT, SPT, TLH6

Human Chr (Location): 2q37.3; chr2:240868745-240879119 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human AGXT

Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix )
 
Mice homozygous for a null allele exhibit increased urinary oxalate levels and male mice suffer from bladder stones.
 
Human Diseases Modeled in Mice Using Agxt (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Agxt interacts with 20 markers (Mir17, Mir34a, Mir129-1, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (2 records)
Data Summary: Results (107)    Tissues (106)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 94
Northern blot 12
RNase protection 1
cDNA source data(48)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase agxt ; ZFIN agxta, agxtb    NEW 
Molecular
reagents
All nucleic(51) Genomic(1) cDNA(48) Primer pair(2)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000048639 (Evidence)
Ensembl Gene Model ENSMUSG00000026272 (Evidence)
Entrez Gene 11611 (Evidence)
UniGene 7457
DFCI TC1581591
DoTS DT.531734, DT.97400786
NIA Mouse Gene Index U000625
EC 2.6.1.51, 2.6.1.44
PDB 3KGX, 3KGW
Consensus CDS Project CCDS15184.1
International Mouse Phenotyping Consortium Status Agxt
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000048639 VEGA Gene Model | MGI Sequence Detail 10182 C57BL/6J ±  kb
transcript OTTMUST00000124577 VEGA | MGI Sequence Detail 1553 Not Applicable 
polypeptide OTTMUSP00000067759 VEGA | MGI Sequence Detail 414 Not Applicable 

For the selected sequences
All sequences(26) RefSeq(4) UniProt(2)
Polymorphisms
PCR(1) : SNPs within 2kb(83 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000192 Aminotransferase, class V/Cysteine desulfurase
InterPro IPR020578 Aminotransferase class-V pyridoxal-phosphate binding site
InterPro IPR015424 Pyridoxal phosphate-dependent transferase
InterPro IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1
InterPro IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2
InterPro IPR024169 Serine-pyruvate aminotransferase/2-aminoethylphosphonate-pyruvate transaminase
Protein Ontology PR:000030629 serine--pyruvate aminotransferase
References
(Earliest) J:117428 Danpure CJ, et al., Evolution of alanine:glyoxylate aminotransferase 1 peroxisomal and mitochondrial targeting. A survey of its subcellular distribution in the livers of various representatives of the classes Mammalia, Aves and Amphibia. Eur J Cell Biol. 1994 Aug;64(2):295-313
(Latest) J:218171 Falix FA, et al., Hepatic Notch2 deficiency leads to bile duct agenesis perinatally and secondary bile duct formation after weaning. Dev Biol. 2014 Dec 15;396(2):201-13
All references(31)
Disease annotation references (1)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory