Agxt
Gene Detail

Symbol Name ID

Agxt alanine-glyoxylate aminotransferase MGI:1329033

Synonyms

Agt1, Agxt1

Feature Type

protein coding gene

Genetic Map

Chromosome 1

47.00 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr1:93135276-93145421 bp, + strand From NCBI annotation of GRCm38   10146 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:37251  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 2 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: serine--pyruvate aminotransferase
Gene Tree: Agxt

Human homologs

Human Homolog		AGXT, alanine-glyoxylate aminotransferase
NCBI Gene ID		189
neXtProt AC		NX_P21549
Human Synonyms		AGT, AGT1, AGXT1, PH1, SPAT, SPT, TLH6
Human Chr (Location)		2q37.3; chr2:241808162-241818536 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human AGXT

Alleles and phenotypes

All alleles(2) : Targeted(2)
 

Mice homozygous for a null allele exhibit increased urinary oxalate levels and male mice suffer from bladder stones.

 
Human Diseases Modeled Using Mouse Agxt (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (33 annotations)

Process	glycine biosynthetic process, by transamination of glyoxylate, glyoxylate catabolic process, ...
Component	mitochondrial matrix, mitochondrion, ...
Function	alanine-glyoxylate transaminase activity, amino acid binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (107)    Tissues (106)   
Theiler Stages: 22, 23, 28

Assay Type	Results
RNA in situ	94
Northern blot	12
RNase protection	1

cDNA source data(48)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(51) Genomic(1) cDNA(48) Primer pair(2)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000026272 (Evidence)
Entrez Gene	11611 (Evidence)
UniGene	7457
DFCI	TC1581591
DoTS	DT.531734, DT.97400786
NIA Mouse Gene Index	U000625
EC	2.6.1.44, 2.6.1.51
PDB	3KGW, 3KGX
Consensus CDS Project	CCDS15184.1
International Mouse Knockout Project Status	Agxt

Sequences

Length	Strain/Species
genomic	11611	NCBI Gene Model | MGI Sequence Detail	10146	C57BL/6J
transcript	NM_016702	RefSeq | MGI Sequence Detail	1553	C57BL/6
polypeptide	O35423	UniProt | EBI | MGI Sequence Detail	414	Not Applicable

All sequences(19) RefSeq(4) UniProt(2)

Polymorphisms

PCR(1) : SNPs(69 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000192	Aminotransferase, class V/Cysteine desulfurase
InterPro	IPR020578	Aminotransferase class-V pyridoxal-phosphate binding site
InterPro	IPR015424	Pyridoxal phosphate-dependent transferase
InterPro	IPR015421	Pyridoxal phosphate-dependent transferase, major region, subdomain 1
InterPro	IPR015422	Pyridoxal phosphate-dependent transferase, major region, subdomain 2
InterPro	IPR024169	Serine-pyruvate aminotransferase/2-aminoethylphosphonate-pyruvate transaminase
Protein Ontology	PR:000033408	serine--pyruvate aminotransferase, mitochondrial

Graphical View of Protein Domain Structure

References

(Earliest) J:117428 Danpure CJ, et al., Evolution of alanine:glyoxylate aminotransferase 1 peroxisomal and mitochondrial targeting. A survey of its subcellular distribution in the livers of various representatives of the classes Mammalia, Aves and Amphibia. Eur J Cell Biol. 1994 Aug;64(2):295-313
(Latest) J:181969 Knight J, et al., Hydroxyproline metabolism in mouse models of primary hyperoxaluria. Am J Physiol Renal Physiol. 2012 Mar;302(6):F688-93
All references(31)