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Stam Gene Detail
Summary
  • Symbol
    Stam
  • Name
    signal transducing adaptor molecule (SH3 domain and ITAM motif) 1
  • Synonyms
    STAM1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1329014
    NCBI Gene: 20844
Location & Maps
more
  • Sequence Map
    Chr2:14074098-14149634 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      75537 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 10.36 cM, cytoband A2-B
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    STAM, signal transducing adaptor molecule
  • Vertebrate Orthologs
    10
  • Human Ortholog
    STAM, signal transducing adaptor molecule
    Orthology source: HGNC, HomoloGene
  • Synonyms
    STAM1, STAM-1
  • Links
    NCBI Gene ID: 8027
    neXtProt AC: NX_Q92783

  • Chr Location
    10p14-p13; chr10:17644125-17716824 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 37788
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: STAM
  • Protein SuperFamily
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    3 phenotypes from multigenic genotypes
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    22
  • Gene trapped
    20
  • Targeted
    2
  • Incidental Mutations
Mice homozygous for a targeted null mutation exhibit progressive growth retardation, priapism, male infertility, degeneration of hippocapal CA3 pyramidal neurons and premature death, but exhibit normal lymphocyte development, proliferation and responses.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000011399 VEGA Gene Model | MGI Sequence Detail 75537 C57BL/6J ±  kb
transcript OTTMUST00000026673 VEGA | MGI Sequence Detail 5000 Not Applicable  
polypeptide OTTMUSP00000012191 VEGA | MGI Sequence Detail 548 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    132 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 88
    cDNA 88

    Microarray probesets 6
References
more
  • Summaries
    All 31
    Developmental Gene Expression 2
    Gene Ontology 4
    Phenotypes 6
  • Earliest
    J:51739 Takeshita T, et al., Cloning of a novel signal-transducing adaptor molecule containing an SH3 domain and ITAM. Biochem Biophys Res Commun. 1996 Aug 23;225(3):1035-9
  • Latest
    J:221937 Watson JA, et al., Motor and Sensory Deficits in the teetering Mice Result from Mutation of the ESCRT Component HGS. PLoS Genet. 2015 Jun;11(6):e1005290

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory