About   Help   FAQ
Slfn4 Gene Detail
Summary
  • Symbol
    Slfn4
  • Name
    schlafen 4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1329010
    NCBI Gene: 20558
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:83175186-83190216 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 50.30 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    63 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1329010
protein coding gene Chr11:83175172-83190216 (+)
129S1/SvImJ MGP_129S1SvImJ_G0018841
protein coding gene Chr11:84486403-84504060 (+)
A/J MGP_AJ_G0018808
protein coding gene Chr11:81283796-81299541 (+)
AKR/J MGP_AKRJ_G0018778
protein coding gene Chr11:83689381-83705243 (+)
BALB/cJ MGP_BALBcJ_G0018781
protein coding gene Chr11:81690302-81705137 (+)
C3H/HeJ MGP_C3HHeJ_G0018595
protein coding gene Chr11:83738390-83755074 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019233
protein coding gene Chr11:87079469-87095684 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016867
protein coding gene Chr11:78077286-78091133 (+)
CAST/EiJ MGP_CASTEiJ_G0018150
protein coding gene Chr11:84341622-84376834 (+)
CBA/J MGP_CBAJ_G0018566
protein coding gene Chr11:90854603-90876136 (+)
DBA/2J MGP_DBA2J_G0018674
protein coding gene Chr11:80848314-80863343 (+)
FVB/NJ MGP_FVBNJ_G0018663
protein coding gene Chr11:80364618-80380802 (+)
LP/J MGP_LPJ_G0018744
protein coding gene Chr11:85019159-85040796 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018690
protein coding gene Chr11:91021776-91039199 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019273
protein coding gene Chr11:83967847-83983403 (+)
PWK/PhJ MGP_PWKPhJ_G0017920
protein coding gene Chr11:81641235-81658077 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017711
protein coding gene Chr11:83514576-83531718 (+)
WSB/EiJ MGP_WSBEiJ_G0018201
protein coding gene Chr11:83832302-83852694 (+)



Homology
more
  • Human Ortholog
    SLFN12L, schlafen family member 12 like
  • Vertebrate Orthologs
    4
  • Human Ortholog
    SLFN12L, schlafen family member 12 like
    Orthology source: HomoloGene
  • Links
    NCBI Gene ID: 100506736
    neXtProt AC: NX_Q6IEE8
    UniProt: Q6IEE8

  • Chr Location
    chr17:35474906-35537861 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000000204 Ensembl Gene Model | MGI Sequence Detail 15031 C57BL/6J ±  kb
transcript ENSMUST00000167596 Ensembl | MGI Sequence Detail 3703 Not Applicable  
polypeptide ENSMUSP00000132595 Ensembl | MGI Sequence Detail 602 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    7 Sequences
  • InterPro Domains
    IPR007421 Schlafen, AlbA_2 domain
    IPR038461 Schlafen, AlbA_2 domain superfamily
    IPR029684 Schlafen family
Molecular
Reagents
less
  • All nucleic 27
    Genomic 1
    cDNA 26

    Microarray probesets 3
Other
Accession IDs
less
MGI:2144170
References
more
  • Summaries
    All 37
    Developmental Gene Expression 1
    Gene Ontology 1
    Phenotypes 13
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:237121 Ding L, et al., Schlafen 4-expressing myeloid-derived suppressor cells are induced during murine gastric metaplasia. J Clin Invest. 2016 Aug 01;126(8):2867-80

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
10/08/2019
MGI 6.14
The Jackson Laboratory