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Slfn3 Gene Detail
Summary
  • Symbol
    Slfn3
  • Name
    schlafen 3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1329005
    NCBI Gene: 20557
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:83191330-83215154 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 50.30 cM, cytoband B5
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    59 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1329005
protein coding gene Chr11:83191330-83215154 (+)
129S1/SvImJ MGP_129S1SvImJ_G0018842
protein coding gene Chr11:84505169-84533069 (+)
A/J MGP_AJ_G0018809
protein coding gene Chr11:81300650-81324242 (+)
AKR/J MGP_AKRJ_G0018779
protein coding gene Chr11:83706352-83730918 (+)
BALB/cJ MGP_BALBcJ_G0018782
protein coding gene Chr11:81706246-81727334 (+)
C3H/HeJ MGP_C3HHeJ_G0018596
protein coding gene Chr11:83756183-83785470 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019234
protein coding gene Chr11:87096793-87127099 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016868
protein coding gene Chr11:78088059-78090848 (+)
CAST/EiJ MGP_CASTEiJ_G0018151
protein coding gene Chr11:84380908-84383550 (+)
CBA/J MGP_CBAJ_G0018567
protein coding gene Chr11:90877245-90905813 (+)
DBA/2J MGP_DBA2J_G0018675
protein coding gene Chr11:80864447-80890651 (+)
FVB/NJ MGP_FVBNJ_G0018664
protein coding gene Chr11:80381911-80403773 (+)
LP/J MGP_LPJ_G0018745
protein coding gene Chr11:85041905-85119498 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018691
protein coding gene Chr11:91040308-91066375 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019274
protein coding gene Chr11:83984512-84009732 (+)
PWK/PhJ no annotation
SPRET/EiJ MGP_SPRETEiJ_G0017712
protein coding gene Chr11:83532827-83558514 (+)
WSB/EiJ MGP_WSBEiJ_G0018202
protein coding gene Chr11:83853803-83878886 (+)



Homology
more
  • Human Ortholog
    SLFN12L, schlafen family member 12 like
  • Vertebrate Orthologs
    4
  • Human Ortholog
    SLFN12L, schlafen family member 12 like
    Orthology source: HomoloGene
  • Links
    NCBI Gene ID: 100506736
    neXtProt AC: NX_Q6IEE8
    UniProt: Q6IEE8

  • Chr Location
    chr17:35474906-35537861 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    12 phenotype references
Mice homozygous for a targeted allele exhibit normal immune cell populations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 20557 NCBI Gene Model | MGI Sequence Detail 23825 C57BL/6J ±  kb
transcript NM_011409 RefSeq | MGI Sequence Detail 1834 Not Specified  
polypeptide NP_035539 RefSeq | MGI Sequence Detail 517 Not Specified  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 10
    Genomic 1
    cDNA 8
    Primer pair 1

    Microarray probesets 5
References
more
  • Summaries
    All 28
    Developmental Gene Expression 2
    Gene Ontology 1
    Phenotypes 12
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:258797 Nakagawa K, et al., Schlafen-8 is essential for lymphatic endothelial cell activation in experimental autoimmune encephalomyelitis. Int Immunol. 2018 Mar 8;30(2):69-78

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
03/13/2019
MGI 6.13
The Jackson Laboratory