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Aanat
Gene Detail
 Symbol
Name
ID
Aanat
arylalkylamine N-acetyltransferase
MGI:1328365
Synonyms Nat-2, Nat4, SNAT
Feature Type protein coding gene
Genetic Map
Chromosome 11
81.43 cM, cytoband E2
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr11:116586432-116597680 bp, + strand
From VEGA annotation of GRCm38

  11249 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:31013  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Aanat

Human
homologs
Human Homolog AANAT, aralkylamine N-acetyltransferase
NCBI Gene ID 15
neXtProt AC  NX_Q16613
Human Synonyms  DSPS, SNAT
Human Chr (Location)  17q25.1; chr17:76453351-76470117 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human AANAT
Alleles
and
phenotypes
All alleles(12) : Gene trapped(8) Spontaneous(1) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mutations in this gene result in abnormal melatonin production.
 
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process cellular response to cAMP, circadian rhythm, ...
Component cytoplasm, perinuclear region of cytoplasm
Function 14-3-3 protein binding, aralkylamine N-acetyltransferase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (94)    Tissues (94)   
Theiler Stages: 22
Assay TypeResults
RNA in situ 94
cDNA source data(6)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(10) Genomic(2) cDNA(7) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000003949 (Evidence)
Ensembl Gene ModelENSMUSG00000020804 (Evidence)
Entrez Gene11298 (Evidence)
DFCITC1592617, TC1595115, TC1729034, TC1776634
DoTSDT.101724513, DT.55255563, DT.87050206, DT.91335053
EC2.3.1.5, 2.3.1.87
Consensus CDS ProjectCCDS25671.1
International Mouse Knockout Project StatusAanat
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000003949 VEGA Gene Model | MGI Sequence Detail 11249 C57BL/6J ±  kb
transcript OTTMUST00000008761 VEGA | MGI Sequence Detail 1353 Not Applicable 
polypeptide OTTMUSP00000004270 VEGA | MGI Sequence Detail 205 Not Applicable 

For the selected sequences
All sequences(51) RefSeq(7) UniProt(6)
Polymorphisms RFLP(1) : SNPs within 2kb(102 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016181 Acyl-CoA N-acyltransferase
InterPro IPR000182 GNAT domain
Protein Ontology PR:000003528 serotonin N-acetyltransferase
References (Earliest) J:8150 Ebihara S, et al., Genetic control of melatonin synthesis in the pineal gland of the mouse. Science. 1986 Jan 31;231(4737):491-3
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(34)
Other
accession IDs
MGD-MRK-12779, MGD-MRK-12781, MGI:97280

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory