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Aanat Gene Detail
Summary
  • Symbol
    Aanat
  • Name
    arylalkylamine N-acetyltransferase
  • Synonyms
    Nat-2, Nat4, SNAT
  • Feature Type
    protein coding gene
  • IDs
    MGI:1328365
    NCBI Gene: 11298
  • Gene Overview
    MyGene.info: AANAT
Location & Maps
more
  • Sequence Map
    Chr11:116586432-116597680 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      11249 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    AANAT, aralkylamine N-acetyltransferase
  • Vertebrate Orthologs
    11
  • Human Ortholog
    AANAT, aralkylamine N-acetyltransferase
    Orthology source: HGNC, HomoloGene
  • Synonyms
    DSPS, SNAT
  • Links
    NCBI Gene ID: 15
    neXtProt AC: NX_Q16613

  • Chr Location
    17q25.1; chr17:76452853-76470790 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 31013
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;2 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: AANAT
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human AANAT associations

Human Disease Mouse Models
       Delayed Sleep Phase Syndrome, Susceptibility To; DSPS   OMIM: 614163
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    12
  • Gene trapped
    8
  • Spontaneous
    1
  • Targeted
    3
  • Incidental Mutations
Mutations in this gene result in abnormal melatonin production.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000003949 VEGA Gene Model | MGI Sequence Detail 11249 C57BL/6J ±  kb
transcript OTTMUST00000008761 VEGA | MGI Sequence Detail 1353 Not Applicable  
polypeptide OTTMUSP00000004270 VEGA | MGI Sequence Detail 205 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    92 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
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  • All nucleic 10
    Genomic 2
    cDNA 7
    Other 1

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-12779, MGD-MRK-12781, MGI:97280
References
more
  • Summaries
    All 31
    Developmental Gene Expression 2
    Gene Ontology 5
    Phenotypes 9
  • Earliest
    J:8150 Ebihara S, et al., Genetic control of melatonin synthesis in the pineal gland of the mouse. Science. 1986 Jan 31;231(4737):491-3
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/19/2016
MGI 6.03
The Jackson Laboratory