Fmod
Gene Detail

Symbol Name ID

Fmod fibromodulin MGI:1328364

Synonyms

SLRR2E

Feature Type

protein coding gene

Genetic Map

Chromosome 1

58.09 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr1:134037254-134048277 bp, + strand From VEGA annotation of GRCm38   11024 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1530  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: class II small leucine-rich proteoglycan
Gene Tree: Fmod

Human homologs

Human Homolog		FMOD, fibromodulin
NCBI Gene ID		2331
neXtProt AC		NX_Q06828
Human Synonyms		SLRR2E
Human Chr (Location)		1q32; chr1:203309752-203320289 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(4) : Targeted(4)
 

Mice homozygous for a targeted null mutation contain more immature, small diameter collagen fibrils in the tendon and display an increase in age-dependent osteoarthritis and degenerative changes of the articular cartilage.

 
Alleles Annotated to Human Diseases(1)    Phenotype Images(5)

Gene Ontology (GO) classifications

All GO classifications: (7 annotations)

Component

extracellular matrix, extracellular region, ...

External Resources: FuncBase

Expression

Literature Summary: (16 records)
Data Summary: Results (532)    Tissues (83)    Images (38)
Theiler Stages: 19, 23, 28

Assay Type	Results
RNA in situ	530
RT-PCR	2

cDNA source data(105)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(108) Genomic(2) cDNA(105) Primer pair(1)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000034789 (Evidence)
Ensembl Gene Model	ENSMUSG00000041559 (Evidence)
Entrez Gene	14264 (Evidence)
UniGene	287146
DFCI	TC1572226, TC1744281
DoTS	DT.102557661, DT.110886095, DT.490515, DT.94149360
NIA Mouse Gene Index	U000819
Consensus CDS Project	CCDS15301.1
International Mouse Knockout Project Status	Fmod

Sequences

Length	Strain/Species
genomic	OTTMUSG00000034789	VEGA Gene Model | MGI Sequence Detail	11024	C57BL/6J
transcript	OTTMUST00000088428	VEGA | MGI Sequence Detail	3120	Not Applicable
polypeptide	OTTMUSP00000048187	VEGA | MGI Sequence Detail	376	Not Applicable

All sequences(38) RefSeq(2) UniProt(5)

Polymorphisms

SNPs(52 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR027215	Fibromodulin
InterPro	IPR001611	Leucine-rich repeat
InterPro	IPR000372	Leucine-rich repeat-containing N-terminal
InterPro	IPR003591	Leucine-rich repeat, typical subtype
Protein Ontology	PR:000007579	fibromodulin

References

(Earliest) J:51376 Aszodi A, et al., Collagen II is essential for the removal of the notochord and the formation of intervertebral discs. J Cell Biol. 1998 Nov 30;143(5):1399-412
(Latest) J:190746 Osuala K, et al., Physiological and genomic consequences of adrenergic deficiency during embryonic/fetal development in mice: impact on retinoic acid metabolism. Physiol Genomics. 2012 Oct 2;44(19):934-47
All references(62)

Other accession IDs

MGI:2138163, MGI:2138492