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Fmod
Gene Detail
Symbol

Name
ID
Fmod
fibromodulin
MGI:1328364
Synonyms
SLRR2E
Feature Type
protein coding gene
Genetic Map
Chromosome 1
58.09 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr1:134037254-134048277 bp, + strand
From VEGA annotation of GRCm38

  11024 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1530  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: FMOD
Protein SuperFamily: class II small leucine-rich proteoglycan
Gene Tree: Fmod

Human
homologs
FMOD, fibromodulin
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 2331
neXtProt AC: NX_Q06828

Human Synonyms: FM, SLRR2E

Human Chr (Location): 1q32; chr1:203340621-203351429 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a targeted null mutation contain more immature, small diameter collagen fibrils in the tendon and display an increase in age-dependent osteoarthritis and degenerative changes of the articular cartilage.
 
Mutations Annotated to Human Diseases (1)    Phenotype Images(5)
Interactions
Fmod interacts with 186 markers (Mir10a, Mir10b, Mir17, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (7 annotations)
Component extracellular matrix, extracellular region, ...
External Resources: FuncBase
Expression
Literature Summary: (20 records)
Data Summary: Results (521)    Tissues (82)    Images (38)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 519
RT-PCR 2
cDNA source data(105)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: ZFIN fmoda, fmodb    NEW 
Molecular
reagents
All nucleic(108) Genomic(2) cDNA(105) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000034789 (Evidence)
Ensembl Gene Model ENSMUSG00000041559 (Evidence)
Entrez Gene 14264 (Evidence)
UniGene 287146
DFCI TC1572226, TC1744281
DoTS DT.490515, DT.110886095, DT.102557661, DT.94149360
NIA Mouse Gene Index U000819
Consensus CDS Project CCDS15301.1
International Mouse Phenotyping Consortium Status Fmod
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034789 VEGA Gene Model | MGI Sequence Detail 11024 C57BL/6J ±  kb
transcript OTTMUST00000088428 VEGA | MGI Sequence Detail 3120 Not Applicable 
polypeptide OTTMUSP00000048187 VEGA | MGI Sequence Detail 376 Not Applicable 

For the selected sequences
All sequences(38) RefSeq(2) UniProt(5)
Polymorphisms
SNPs within 2kb(68 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR027215 Fibromodulin
InterPro IPR001611 Leucine-rich repeat
InterPro IPR000372 Leucine-rich repeat-containing N-terminal
InterPro IPR003591 Leucine-rich repeat, typical subtype
Protein Ontology PR:000007579 fibromodulin
References
(Earliest) J:51376 Aszodi A, et al., Collagen II is essential for the removal of the notochord and the formation of intervertebral discs. J Cell Biol. 1998 Nov 30;143(5):1399-412
(Latest) J:218940 Barnette DN, et al., RNA-seq analysis to identify novel roles of scleraxis during embryonic mouse heart valve remodeling. PLoS One. 2014;9(7):e101425
All references(71)
Other
accession IDs
MGI:2138163, MGI:2138492

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory