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Fmod
Gene Detail
 Symbol
Name
ID
Fmod
fibromodulin
MGI:1328364
Synonyms SLRR2E
Feature Type protein coding gene
Genetic Map
Chromosome 1
58.09 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr1:134037254-134048277 bp, + strand
From VEGA annotation of GRCm38

  11024 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1530  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: class II small leucine-rich proteoglycan
Gene Tree: Fmod

Human
homologs
Human Homolog FMOD, fibromodulin
NCBI Gene ID 2331
neXtProt AC  NX_Q06828
Human Synonyms  FM, SLRR2E
Human Chr (Location)  1q32; chr1:203340621-203351429 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a targeted null mutation contain more immature, small diameter collagen fibrils in the tendon and display an increase in age-dependent osteoarthritis and degenerative changes of the articular cartilage.
 
Alleles Annotated to Human Diseases(1)    Phenotype Images(5)
Interactions
Fmod interacts with 187 markers (Mir10a, Mir10b, Mir17, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (7 annotations)
Component extracellular matrix, extracellular region, ...
External Resources: FuncBase
Expression
Literature Summary: (19 records)
Data Summary: Results (521)    Tissues (82)    Images (38)
Theiler Stages: 19, 23, 28
Assay TypeResults
RNA in situ 519
RT-PCR 2
cDNA source data(105)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(108) Genomic(2) cDNA(105) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000034789 (Evidence)
Ensembl Gene ModelENSMUSG00000041559 (Evidence)
Entrez Gene14264 (Evidence)
UniGene287146
DFCITC1572226, TC1744281
DoTSDT.102557661, DT.110886095, DT.490515, DT.94149360
NIA Mouse Gene IndexU000819
Consensus CDS ProjectCCDS15301.1
International Mouse Knockout Project StatusFmod
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034789 VEGA Gene Model | MGI Sequence Detail 11024 C57BL/6J ±  kb
transcript OTTMUST00000088428 VEGA | MGI Sequence Detail 3120 Not Applicable 
polypeptide OTTMUSP00000048187 VEGA | MGI Sequence Detail 376 Not Applicable 

For the selected sequences
All sequences(38) RefSeq(2) UniProt(5)
Polymorphisms SNPs within 2kb(68 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR027215 Fibromodulin
InterPro IPR001611 Leucine-rich repeat
InterPro IPR000372 Leucine-rich repeat-containing N-terminal
InterPro IPR003591 Leucine-rich repeat, typical subtype
Protein Ontology PR:000007579 fibromodulin
References (Earliest) J:51376 Aszodi A, et al., Collagen II is essential for the removal of the notochord and the formation of intervertebral discs. J Cell Biol. 1998 Nov 30;143(5):1399-412
(Latest) J:210370 Steinhart MR, et al., Susceptibility to glaucoma damage related to age and connective tissue mutations in mice. Exp Eye Res. 2014 Feb;119:54-60
All references(67)
Other
accession IDs
MGI:2138163, MGI:2138492

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory