Ccnt1 MGI Mouse Gene Detail - MGI:1328363

Ccnt1 Gene Detail

Symbol

Ccnt1
Name

cyclin T1
Synonyms

2810478G24Rik, CycT1

Feature Type

protein coding gene
IDs

MGI:1328363
NCBI Gene: 12455
Gene Overview

MyGene.info: CCNT1

Sequence Map

Chr15:98538689-98570923 bp, - strand
From VEGA annotation of GRCm38

Mouse Genome Browser
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Sequence

32235 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 54.54 cM, cytoband F2
Mapping Data

3 experiments

Human Ortholog

CCNT1, cyclin T1

Vertebrate Orthologs

9

Human Ortholog

CCNT1, cyclin T1
Orthology source: HomoloGene, HGNC
Synonyms

CCNT, CYCT1, HIVE1
Links

HGNC:1599

NCBI Gene ID: 904

neXtProt AC: NX_O60563
Chr Location

12q13.11; chr12:48688458-48716998 (-) GRCh38.p2

HomoloGene

Vertebrate Homology Class 947
1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish
HCOP

human homology predictions: CCNT1
Protein SuperFamily

cyclin, T/K types
Gene Tree

Ccnt1

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References

1 with disease annotations

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Phenotype Summary

28 phenotype references

All Mutations and Alleles

17
Chemically induced (other)

1
Gene trapped

13
Radiation induced

2
Targeted

1
Genomic Mutations

3 involving Ccnt1
Incidental Mutations

Mutagenetix , APF , CvDC

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All GO Annotations

28
GO References

10

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

59
Tissues

45
cDNA Data

16
Literature Summary

6

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO
Other Vertebrate Links

Xenbase ccnt1

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Ccnt1 interacts with 441 markers (Mir1a-1, Mir1a-2, Mir1b, ...) View All

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All Sequences

47
RefSeq

3
UniProt

2
CCDS

CCDS27797.1

			Length	Strain/Species	Flank
genomic	OTTMUSG00000035789	VEGA Gene Model \| MGI Sequence Detail	32235	C57BL/6J	± kb
transcript	OTTMUST00000091602	VEGA \| MGI Sequence Detail	7397	Not Applicable
polypeptide	OTTMUSP00000050470	VEGA \| MGI Sequence Detail	724	Not Applicable

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SNPs within 2kb

205 from dbSNP Build 142

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UniProt

2 Sequences
Protein Ontology

PR:000005139 cyclin-T1
InterPro Domains

IPR013763 Cyclin-like

IPR006671 Cyclin, N-terminal

IPR028863 Cyclin-T1

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All nucleic 16

cDNA 16

Microarray probesets 5

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MGI:1920080, MGI:2145948

Summaries

All 54

Developmental Gene Expression 6

Diseases 1

Gene Ontology 10

Phenotypes 28
Earliest

J:51312 Garber ME, et al., The interaction between HIV-1 Tat and human cyclin T1 requires zinc and a critical cysteine residue that is not conserved in the murine CycT1 protein. Genes Dev. 1998 Nov 15;12(22):3512-27
Latest

J:192997 Dai Q, et al., Cyclin K-containing kinase complexes maintain self-renewal in murine embryonic stem cells. J Biol Chem. 2012 Jul 20;287(30):25344-52

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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