Unc119
Gene Detail

Symbol Name ID

Unc119 unc-119 homolog (C. elegans) MGI:1328357

Synonyms

HRG4, MRG4, Rg4, Rtg4, UNC119, Unc119h

Feature Type

protein coding gene

Genetic Map

Chromosome 11

46.74 cM, cytoband B5
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr11:78343482-78349164 bp, + strand From VEGA annotation of GRCm38   5683 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:3778  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Gene Tree: Unc119

Human homologs

Human Homolog		UNC119, unc-119 homolog (C. elegans)
NCBI Gene ID		9094
neXtProt AC		NX_Q13432
Human Synonyms		HRG4, POC7, POC7A
Human Chr (Location)		17q11.2; chr17:26873725-26879646 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human UNC119

Alleles and phenotypes

All alleles(2) : Targeted(2)
 

Mice homozygous for a null allele exhibit retinal degeneration characterized by thinning of the outer nuclear layer of the retinal that is visible at 6 months and progresses rapidly after 17 to end-stage by 26 months.

 

Gene Ontology (GO) classifications

All GO classifications: (10 annotations)

Process	lipoprotein transport, protein transport, ...
Component	centrosome, cytoplasm, ...
Function	lipid binding

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (42)    Tissues (11)    Images (35)
Theiler Stages: 20, 22, 23, 24, 26, 28

Assay Type	Results
RNA in situ	42

cDNA source data(85)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(87) Genomic(1) cDNA(86)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000000135 (Evidence)
Ensembl Gene Model	ENSMUSG00000002058 (Evidence)
Entrez Gene	22248 (Evidence)
UniGene	284811
DFCI	TC1578261
DoTS	DT.493495
NIA Mouse Gene Index	U013018
Consensus CDS Project	CCDS25101.1
International Mouse Knockout Project Status	Unc119

Sequences

Length	Strain/Species
genomic	OTTMUSG00000000135	VEGA Gene Model | MGI Sequence Detail	5683	C57BL/6J
transcript	OTTMUST00000000437	VEGA | MGI Sequence Detail	1371	Not Applicable
polypeptide	OTTMUSP00000000190	VEGA | MGI Sequence Detail	262	Not Applicable

All sequences(36) RefSeq(2) UniProt(4)

Polymorphisms

SNPs(1 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR008015	GMP phosphodiesterase, delta subunit
InterPro	IPR014756	Immunoglobulin E-set
Protein Ontology	PR:000017084	protein unc-119 A

References

(Earliest) J:43593 Schorpp M, et al., Characterization of mouse and human nude genes. Immunogenetics. 1997;46(6):509-15
(Latest) J:174011 Zhang H, et al., UNC119 is required for G protein trafficking in sensory neurons. Nat Neurosci. 2011;14(7):874-80
All references(37)

Other accession IDs

MGI:1276531