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Unc119
Gene Detail
Symbol

Name
ID
Unc119
unc-119 homolog (C. elegans)
MGI:1328357
Synonyms
HRG4, MRG4, Rg4, Rtg4, UNC119, Unc119h
Feature Type
protein coding gene
Genetic Map
Chromosome 11
46.74 cM, cytoband B5
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr11:78343482-78349164 bp, + strand
From VEGA annotation of GRCm38

  5683 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3778  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: UNC119
Gene Tree: Unc119

Human
homologs
UNC119, unc-119 lipid binding chaperone
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 9094
neXtProt AC: NX_Q13432

Human Synonyms: HRG4, IMD13, POC7, POC7A

Human Chr (Location): 17q11.2; chr17:28546707-28552628 (-)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human UNC119

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Genomic Mutations involving Unc119 (1)
Incidental mutations (data from APF )
 
Mice homozygous for a null allele exhibit retinal degeneration characterized by thinning of the outer nuclear layer of the retinal that is visible at 6 months and progresses rapidly after 17 to end-stage by 26 months.
 
Interactions
Unc119 interacts with 93 markers (Mir98, Mir101a, Mir101b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process endocytosis, lipoprotein transport, ...
Component centrosome, cytoplasm, ...
Function lipid binding, protein binding
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (42)    Tissues (12)    Images (35)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 42
cDNA source data(83)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase unc119 ; ZFIN unc119a    NEW 
Molecular
reagents
All nucleic(85) Genomic(1) cDNA(84)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000000135 (Evidence)
Ensembl Gene Model ENSMUSG00000002058 (Evidence)
Entrez Gene 22248 (Evidence)
UniGene 284811
DFCI TC1578261
DoTS DT.493495
NIA Mouse Gene Index U013018
Consensus CDS Project CCDS25101.1
International Mouse Phenotyping Consortium Status Unc119
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000000135 VEGA Gene Model | MGI Sequence Detail 5683 C57BL/6J ±  kb
transcript OTTMUST00000000437 VEGA | MGI Sequence Detail 1371 Not Applicable 
polypeptide OTTMUSP00000000190 VEGA | MGI Sequence Detail 262 Not Applicable 

For the selected sequences
All sequences(38) RefSeq(4) UniProt(4)
Polymorphisms
SNPs within 2kb(13 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008015 GMP phosphodiesterase, delta subunit
InterPro IPR014756 Immunoglobulin E-set
Protein Ontology PR:000017084 protein unc-119 homolog A
References
(Earliest) J:43593 Schorpp M, et al., Characterization of mouse and human nude genes. Immunogenetics. 1997;46(6):509-15
(Latest) J:174011 Zhang H, et al., UNC119 is required for G protein trafficking in sensory neurons. Nat Neurosci. 2011;14(7):874-80
All references(40)
Other
accession IDs
MGI:1276531

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory