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Rad9a
Gene Detail
Symbol

Name
ID
Rad9a
RAD9 homolog A
MGI:1328356
Synonyms
Rad9
Feature Type
protein coding gene
Genetic Map
Chromosome 19
3.89 cM, cytoband A
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr19:4195198-4201603 bp, - strand
From Ensembl annotation of GRCm38

  6406 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:32118  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: RAD9A
Protein SuperFamily: cell cycle checkpoint protein, RAD9 type
Gene Tree: Rad9a

Human
homologs
RAD9A, RAD9 checkpoint clamp component A
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 5883
neXtProt AC: NX_Q99638

Human Synonyms: RAD9

Human Chr (Location): 11q13.1-q13.2; chr11:67391952-67398412 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(14) : Gene trapped(8) Targeted(6)
Incidental mutations (data from APF )
 
Embryos homozygous for a knock-out allele are consistently smaller and display abnormal embryonic development and midgestational lethality associated with increased apoptosis and reduced cellular proliferation. Mutant mouse embryonic fibroblasts are not viable.
 
Interactions
Rad9a interacts with 119 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (30 annotations)
Process cell cycle checkpoint, cellular response to DNA damage stimulus, ...
Component checkpoint clamp complex, cytoplasm, ...
Function 3'-5' exonuclease activity, enzyme binding, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
cDNA source data(48)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase rad9a ; ZFIN zgc:56197    NEW 
Molecular
reagents
All nucleic(49) Genomic(1) cDNA(48)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000024824 (Evidence)
Entrez Gene 19367 (Evidence)
UniGene 277629
DFCI TC1743367, TC1578627
EC 3.1.11.2
Consensus CDS Project CCDS29422.1
International Mouse Phenotyping Consortium Status Rad9a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024824 Ensembl Gene Model | MGI Sequence Detail 6406 C57BL/6J ±  kb
transcript ENSMUST00000025740 Ensembl | MGI Sequence Detail 2046 Not Applicable 
polypeptide ENSMUSP00000025740 Ensembl | MGI Sequence Detail 389 Not Applicable 

For the selected sequences
All sequences(21) RefSeq(4) UniProt(1)
Polymorphisms
SNPs within 2kb(20 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR026584 Rad9
InterPro IPR007268 Rad9/Ddc1
Protein Ontology PR:000013682 cell cycle checkpoint control protein RAD9A
References
(Earliest) J:50019 Richter MF, et al., Specific contribution of Tyk2 JH regions to the binding and the expression of the interferon alpha/beta receptor component IFNAR1. J Biol Chem. 1998 Sep 18;273(38):24723-9
(Latest) J:213512 Werber M, et al., The tissue-specific transcriptomic landscape of the mid-gestational mouse embryo. Development. 2014 Jun;141(11):2325-30
All references(47)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
06/30/2015
MGI 5.22
The Jackson Laboratory