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Rad9a
Gene Detail
Symbol

Name
ID
Rad9a
RAD9 homolog A
MGI:1328356
Synonyms
Rad9
Feature Type
protein coding gene
Genetic Map
Chromosome 19
3.89 cM, cytoband A
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr19:4195198-4201603 bp, - strand
From NCBI annotation of GRCm38

  6406 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:32118  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

Protein SuperFamily: cell cycle checkpoint protein, RAD9 type
Gene Tree: Rad9a

Human
homologs
Human Homolog RAD9A, RAD9 homolog A (S. pombe)
NCBI Gene ID 5883
neXtProt AC  NX_Q99638
Human Synonyms  RAD9
Human Chr (Location)  11q13.1-q13.2; chr11:67391952-67398412 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(13) : Gene trapped(8) Targeted(5)
Incidental mutations (data from APF )
 
Embryos homozygous for a knock-out allele are consistently smaller and display abnormal embryonic development and midgestational lethality associated with increased apoptosis and reduced cellular proliferation. Mutant mouse embryonic fibroblasts are not viable.
 
Interactions
Rad9a interacts with 119 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (25 annotations)
Process cell cycle checkpoint, cellular response to DNA damage stimulus, ...
Component checkpoint clamp complex, cytoplasm, ...
Function 3'-5' exonuclease activity, enzyme binding, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
cDNA source data(48)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(49) Genomic(1) cDNA(48)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000024824 (Evidence)
Entrez Gene19367 (Evidence)
UniGene277629
DFCITC1578627, TC1743367
EC3.1.11.2
Consensus CDS ProjectCCDS29422.1
International Mouse Knockout Project StatusRad9a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 19367 NCBI Gene Model | MGI Sequence Detail 6406 C57BL/6J ±  kb
transcript NM_011237 RefSeq | MGI Sequence Detail 2046 C57BL/6 
polypeptide Q9Z0F6 UniProt | EBI | MGI Sequence Detail 389 Not Applicable 

For the selected sequences
All sequences(18) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(20 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR026584 Rad9
InterPro IPR007268 Rad9/Ddc1
Protein Ontology PR:000013682 cell cycle checkpoint control protein RAD9A
Graphical View of Protein Domain Structure
References
(Earliest) J:50019 Richter MF, et al., Specific contribution of Tyk2 JH regions to the binding and the expression of the interferon alpha/beta receptor component IFNAR1. J Biol Chem. 1998 Sep 18;273(38):24723-9
(Latest) J:197122 Broustas CG, et al., Rad9 protein contributes to prostate tumor progression by promoting cell migration and anoikis resistance. J Biol Chem. 2012 Nov 30;287(49):41324-33
All references(45)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/11/2014
MGI 5.20
The Jackson Laboratory