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Nts
Gene Detail
Symbol

Name
ID
Nts
neurotensin
MGI:1328351
Synonyms
5033428E16Rik, neuromedin N, NMN-125, NT/N, NTS1
Feature Type
protein coding gene
Genetic Map
Chromosome 10
53.56 cM, cytoband D1
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr10:102481760-102490418 bp, - strand
From Ensembl annotation of GRCm38

  8659 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4506  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: NTS
Protein SuperFamily: neurotensin
Gene Tree: Nts

Human
homologs
NTS, neurotensin
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 4922
neXtProt AC: NX_P30990

Human Synonyms: NMN-125, NN, NT, NT/N, NTS1

Human Chr (Location): 12q21; chr12:85874295-85882992 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
 
Mice homozygous for a targeted null mutation are viable, fertile, and grossly normal, but display altered responses to antipsychotic drugs.
 
Interactions
Nts interacts with 127 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (8 annotations)
Process regulation of blood vessel size, visual learning
Component axon terminus, cytoplasmic vesicle, ...
Function neuropeptide hormone activity
External Resources: FuncBase
Expression
Literature Summary: (17 records)
Data Summary: Results (212)    Tissues (124)    Images (41)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 212
cDNA source data(16)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: GEISHA NTS ; Xenbase nts    NEW 
Molecular
reagents
All nucleic(16) cDNA(16)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000019890 (Evidence)
Entrez Gene 67405 (Evidence)
UniGene 64201
DFCI TC1585100
DoTS DT.521758, DT.94286472
NIA Mouse Gene Index U032184
Consensus CDS Project CCDS24154.1
International Mouse Phenotyping Consortium Status Nts
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000019890 Ensembl Gene Model | MGI Sequence Detail 8659 C57BL/6J ±  kb
transcript ENSMUST00000020040 Ensembl | MGI Sequence Detail 1176 Not Applicable 
polypeptide ENSMUSP00000020040 Ensembl | MGI Sequence Detail 169 Not Applicable 

For the selected sequences
All sequences(19) RefSeq(4) UniProt(1)
Polymorphisms
SNPs within 2kb(45 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008055 Neurotensin/neuromedin N
Protein Ontology PR:000011472 neurotensin/neuromedin N
References
(Earliest) J:51888 Bulfone A, et al., An olfactory sensory map develops in the absence of normal projection neurons or GABAergic interneurons. Neuron. 1998 Dec;21(6):1273-82
(Latest) J:216163 Goforth PB, et al., Leptin acts via lateral hypothalamic area neurotensin neurons to inhibit orexin neurons by multiple GABA-independent mechanisms. J Neurosci. 2014 Aug 20;34(34):11405-15
All references(53)
Other
accession IDs
MGI:1914655

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory