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Nts Gene Detail
Summary
  • Symbol
    Nts
  • Name
    neurotensin
  • Synonyms
    5033428E16Rik, neuromedin N, NMN-125, NT/N, NTS1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1328351
    NCBI Gene: 67405
  • Gene Overview
    MyGene.info: NTS
Location & Maps
more
  • Sequence Map
    Chr10:102481760-102490418 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      8659 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 53.56 cM, cytoband D1
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    NTS, neurotensin
  • Vertebrate Orthologs
    9
  • Human Ortholog
    NTS, neurotensin
    Orthology source: HomoloGene
  • Synonyms
    NMN-125, NN, NT, NT/N, NTS1
  • Links
    NCBI Gene ID: 4922
    neXtProt AC: NX_P30990

  • Chr Location
    12q21; chr12:85874295-85882992 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 2 alleles in 2 genetic backgrounds
    14 phenotypes from multigenic genotypes
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    6
  • Chemically induced (other)
    1
  • Targeted
    5
  • Genomic Mutations
    1 involving Nts
Mice homozygous for a targeted null mutation are viable, fertile, and grossly normal, but display altered responses to antipsychotic drugs.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000019890 Ensembl Gene Model | MGI Sequence Detail 8659 C57BL/6J ±  kb
transcript ENSMUST00000020040 Ensembl | MGI Sequence Detail 1176 Not Applicable  
polypeptide ENSMUSP00000020040 Ensembl | MGI Sequence Detail 169 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    45 from dbSNP Build 142
Protein
Information
less
  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000011472 neurotensin/neuromedin N
  • InterPro Domains
    IPR008055 Neurotensin/neuromedin N
Molecular
Reagents
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  • All nucleic 16
    cDNA 16

    Microarray probesets 4
Other
Accession IDs
less
MGI:1914655
References
more
  • Summaries
    All 53
    Developmental Gene Expression 18
    Gene Ontology 5
    Phenotypes 17
  • Earliest
    J:51888 Bulfone A, et al., An olfactory sensory map develops in the absence of normal projection neurons or GABAergic interneurons. Neuron. 1998 Dec;21(6):1273-82
  • Latest
    J:223865 Chastain LG, et al., Striatal dopamine receptor plasticity in neurotensin deficient mice. Behav Brain Res. 2015 Mar 1;280:160-71

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory