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Ccn5 Gene Detail
Summary
  • Symbol
    Ccn5
  • Name
    cellular communication network factor 5
  • Synonyms
    CCN5, Crgr4, rCop1, Wisp2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1328326
    NCBI Gene: 22403
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:163662781-163675066 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 2, 84.49 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    152 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1328326
protein coding gene Chr2:163662724-163675066 (+)
129S1/SvImJ MGP_129S1SvImJ_G0026830
protein coding gene Chr2:169185670-169197931 (+)
A/J MGP_AJ_G0026796
protein coding gene Chr2:162355842-162368170 (+)
AKR/J MGP_AKRJ_G0026767
protein coding gene Chr2:167157552-167169811 (+)
BALB/cJ MGP_BALBcJ_G0026805
protein coding gene Chr2:162695640-162707970 (+)
C3H/HeJ MGP_C3HHeJ_G0026547
protein coding gene Chr2:167506122-167518452 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027253
protein coding gene Chr2:174120072-174132286 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024623
protein coding gene Chr2:155658729-155671205 (+)
CAST/EiJ MGP_CASTEiJ_G0026008
protein coding gene Chr2:167914303-167927815 (+)
CBA/J MGP_CBAJ_G0026524
protein coding gene Chr2:180397590-180409920 (+)
DBA/2J MGP_DBA2J_G0026662
protein coding gene Chr2:161526707-161538966 (+)
FVB/NJ MGP_FVBNJ_G0026628
protein coding gene Chr2:159899647-159911967 (+)
LP/J MGP_LPJ_G0026765
protein coding gene Chr2:169301748-169314009 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026650
protein coding gene Chr2:184056682-184068969 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027309
protein coding gene Chr2:167058081-167070340 (+)
PWK/PhJ MGP_PWKPhJ_G0025742
protein coding gene Chr2:161093433-161105738 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025545
protein coding gene Chr2:165930478-165942558 (+)
WSB/EiJ MGP_WSBEiJ_G0026078
protein coding gene Chr2:167909721-167922002 (+)



Homology
more
  • Human Ortholog
    CCN5, cellular communication network factor 5
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CCN5, cellular communication network factor 5
  • Synonyms
    CT58, CTGF-L, WISP2
  • Links
    NCBI Gene ID: 8839
    neXtProt AC: NX_O76076
    UniProt: O76076

  • Chr Location
    20q13.12; chr20:44714844-44728509 (+)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 2 alleles in 2 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele are viabe and overtly normal with no adult bone phenotype.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000027656 Ensembl Gene Model | MGI Sequence Detail 12286 C57BL/6J ±  kb
transcript ENSMUST00000029188 Ensembl | MGI Sequence Detail 1719 Not Applicable  
polypeptide ENSMUSP00000029188 Ensembl | MGI Sequence Detail 251 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000017427 CCN family member 5
  • InterPro Domains
    IPR043973 CCN, TSP1 domain
    IPR009030 Growth factor receptor cysteine-rich domain superfamily
    IPR000867 Insulin-like growth factor-binding protein, IGFBP
    IPR017891 Insulin-like growth factor binding protein, N-terminal, Cys-rich conserved site
    IPR000884 Thrombospondin type-1 (TSP1) repeat
    IPR036383 Thrombospondin type-1 (TSP1) repeat superfamily
    IPR001007 VWFC domain
Molecular
Reagents
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  • All nucleic 20
    cDNA 14
    Primer pair 5
    Other 1

    Microarray probesets 3
Other
Accession IDs
less
MGI:1354167
References
more
  • Summaries
    All 51
    Developmental Gene Expression 10
    Gene Ontology 10
    Phenotypes 10
  • Earliest
    J:50091 Zhang R, et al., Identification of rCop-1, a new member of the CCN protein family, as a negative regulator for cell transformation. Mol Cell Biol. 1998 Oct;18(10):6131-41
  • Latest
    J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
03/05/2024
MGI 6.23
The Jackson Laboratory