Syngr1 MGI Mouse Gene Detail - MGI:1328323

Symbol

Syngr1
Name

synaptogyrin 1
Synonyms

p29, Syngr1b

Feature Type

protein coding gene
IDs

MGI:1328323
NCBI Gene: 20972
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr15:79975537-80003702 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 37.85 cM
Mapping Data

2 experiments

SNPs within 2kb

865 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1328323	protein coding gene	Chr15:79975535-80003702 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0022093	protein coding gene	Chr15:80400275-80431833 (+)
A/J	MGP_AJ_G0022054	protein coding gene	Chr15:77623426-77651545 (+)
AKR/J	MGP_AKRJ_G0022029	protein coding gene	Chr15:79791282-79819399 (+)
BALB/cJ	MGP_BALBcJ_G0022060	protein coding gene	Chr15:77630827-77659749 (+)
C3H/HeJ	MGP_C3HHeJ_G0021831	protein coding gene	Chr15:79779769-79809205 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0022503	protein coding gene	Chr15:83567109-83598902 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020033	protein coding gene	Chr15:74102240-74130958 (+)
CAST/EiJ	MGP_CASTEiJ_G0021352	protein coding gene	Chr15:80496732-80527623 (+)
CBA/J	MGP_CBAJ_G0021796	protein coding gene	Chr15:86207813-86247338 (+)
DBA/2J	MGP_DBA2J_G0021925	protein coding gene	Chr15:77115408-77143590 (+)
FVB/NJ	MGP_FVBNJ_G0021903	protein coding gene	Chr15:76136531-76164242 (+)
LP/J	MGP_LPJ_G0021993	protein coding gene	Chr15:80587020-80615995 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021923	protein coding gene	Chr15:91246236-91275574 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022517	protein coding gene	Chr15:79822725-79852043 (+)
PWK/PhJ	MGP_PWKPhJ_G0021094	protein coding gene	Chr15:77123436-77152925 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0020931	protein coding gene	Chr15:79626937-79656316 (+)
WSB/EiJ	MGP_WSBEiJ_G0021404	protein coding gene	Chr15:80221975-80256005 (+)

Human Ortholog

SYNGR1, synaptogyrin 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SYNGR1, synaptogyrin 1
Links

HGNC:11498

NCBI Gene ID: 9145

UniProt: O43759
Chr Location

22q13.1; chr22:39349925-39385575 (+) GRCh38

MGI Vertebrate Homology

Syngr1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: SYNGR1
Protein SuperFamily

Synaptogyrin
Gene Tree

Syngr1

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References

1 with disease annotations

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Phenotype Summary

11 phenotypes from 2 alleles in 2 genetic backgrounds
5 phenotypes from multigenic genotypes
35 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

63
Chemically induced (other)

1
Endonuclease-mediated

4
Gene trapped

53
Radiation induced

2
Targeted

3
Genomic Mutations

3 involving Syngr1
Incidental Mutations

CvDC
Find Mice (IMSR)

41 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit a moderate decrease in post-tetanic potentiation.

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All GO Annotations

27
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

804
Tissues

49
cDNA Data

17
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase syngr1

ZFIN syngr1a

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All Sequences

73
RefSeq

8
UniProt

4
CCDS

CCDS27657.1, CCDS27658.1

Ensembl

ENSMUSG00000022415 (Evidence)
NCBI Gene

20972

			Length	Strain/Species	Flank
genomic	20972	NCBI Gene Model \| MGI Sequence Detail	28166	C57BL/6J	± kb
transcript	NM_001411783	RefSeq \| MGI Sequence Detail	4208	C57BL/6
polypeptide	O55100	UniProt \| EBI \| MGI Sequence Detail	234	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000015878 synaptogyrin-1

(term hierarchy)
InterPro Domains

IPR008253 Marvel domain

IPR016579 Synaptogyrin
GlyGen

O55100 2 sites, 1 O-linked glycan (1 site)

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All nucleic 21

cDNA 18

Other 3

Microarray probesets 7

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MGI:2146324

Summaries

All 68

Developmental Gene Expression 3

Diseases 1

Gene Ontology 10

Phenotypes 35
Earliest

J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Syngr1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr132156	Chr15:79975399-79975408 (+)	-133 bp
Tssr132157	Chr15:79975521-79975591 (+)	19 bp
Tssr132161	Chr15:79994646-79994686 (+)	19,129 bp
Tssr132162	Chr15:79999643-79999689 (+)	24,129 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 03/18/2025 MGI 6.24