Syngr1 MGI Mouse Gene Detail - MGI:1328323

Syngr1 Gene Detail

Symbol

Syngr1
Name

synaptogyrin 1
Synonyms

p29, Syngr1b

Feature Type

protein coding gene
IDs

MGI:1328323
NCBI Gene: 20972
Gene Overview

MyGene.info: SYNGR1

Sequence Map

Chr15:80091334-80119501 bp, + strand
From VEGA annotation of GRCm38

Mouse Genome Browser
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Sequence

28168 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 37.85 cM
Mapping Data

2 experiments

Human Ortholog

SYNGR1, synaptogyrin 1

Vertebrate Orthologs

7

Human Ortholog

SYNGR1, synaptogyrin 1
Orthology source: HomoloGene, HGNC
Links

HGNC:11498

NCBI Gene ID: 9145

neXtProt AC: NX_O43759
Chr Location

22q13.1; chr22:39349949-39385588 (+) GRCh38.p2

HomoloGene

Vertebrate Homology Class 3456
1 human;1 mouse;1 rat;1 rhesus macaque;1 chicken;1 zebrafish;1 frog, western clawed
HCOP

human homology predictions: SYNGR1
Protein SuperFamily

synaptogyrin
Gene Tree

Syngr1

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References

1 with disease annotations

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
5 phenotypes from multigenic genotypes
28 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

71
Chemically induced (other)

1
Gene trapped

65
Radiation induced

2
Targeted

3
Genomic Mutations

3 involving Syngr1
Incidental Mutations

CvDC

Mice homozygous for a knock-out allele exhibit a moderate decrease in post-tetanic potentiation.

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All GO Annotations

13
GO References

6

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

98
Tissues

49
cDNA Data

16
Literature Summary

2

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO
Other Vertebrate Links

Xenbase syngr1

ZFIN syngr1a

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Syngr1 interacts with 283 markers (Mir10a, Mir10b, Mir15b, ...) View All

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All Sequences

62
RefSeq

6
UniProt

4
CCDS

CCDS27657.1, CCDS27658.1

			Length	Strain/Species	Flank
genomic	OTTMUSG00000016389	VEGA Gene Model \| MGI Sequence Detail	28168	C57BL/6J	± kb
transcript	OTTMUST00000039471	VEGA \| MGI Sequence Detail	4180	Not Applicable
polypeptide	OTTMUSP00000017634	VEGA \| MGI Sequence Detail	234	Not Applicable

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SNPs within 2kb

175 from dbSNP Build 142

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UniProt

4 Sequences
Protein Ontology

PR:000015878 synaptogyrin-1
InterPro Domains

IPR008253 Marvel domain

IPR016579 Synaptogyrin

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All nucleic 20

cDNA 17

Other 3

Microarray probesets 7

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MGI:2146324

Summaries

All 36

Developmental Gene Expression 2

Diseases 1

Gene Ontology 6

Phenotypes 28
Earliest

J:50126 Kedra D, et al., Characterization of the human synaptogyrin gene family. Hum Genet. 1998 Aug;103(2):131-41
Latest

J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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