Syngr1 MGI Mouse Gene Detail - MGI:1328323

Symbol

Syngr1
Name

synaptogyrin 1
Synonyms

p29, Syngr1b

Feature Type

protein coding gene
IDs

MGI:1328323
NCBI Gene: 20972
Gene Overview

MyGene.info: SYNGR1
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr15:80091334-80119501 bp, + strand
From NCBI annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 37.85 cM
Mapping Data

2 experiments

SNPs within 2kb

175 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1328323	protein coding gene	Chr15:80091334-80119501 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0022093	protein coding gene	Chr15:80400275-80431833 (+)
A/J	MGP_AJ_G0022054	protein coding gene	Chr15:77623426-77651545 (+)
AKR/J	MGP_AKRJ_G0022029	protein coding gene	Chr15:79791282-79819399 (+)
BALB/cJ	MGP_BALBcJ_G0022060	protein coding gene	Chr15:77630827-77659749 (+)
C3H/HeJ	MGP_C3HHeJ_G0021831	protein coding gene	Chr15:79779769-79809205 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0022503	protein coding gene	Chr15:83567109-83598902 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020033	protein coding gene	Chr15:74102240-74130958 (+)
CAST/EiJ	MGP_CASTEiJ_G0021352	protein coding gene	Chr15:80496732-80527623 (+)
CBA/J	MGP_CBAJ_G0021796	protein coding gene	Chr15:86207813-86247338 (+)
DBA/2J	MGP_DBA2J_G0021925	protein coding gene	Chr15:77115408-77143590 (+)
FVB/NJ	MGP_FVBNJ_G0021903	protein coding gene	Chr15:76136531-76164242 (+)
LP/J	MGP_LPJ_G0021993	protein coding gene	Chr15:80587020-80615995 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021923	protein coding gene	Chr15:91246236-91275574 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022517	protein coding gene	Chr15:79822725-79852043 (+)
PWK/PhJ	MGP_PWKPhJ_G0021094	protein coding gene	Chr15:77123436-77152925 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0020931	protein coding gene	Chr15:79626937-79656316 (+)
WSB/EiJ	MGP_WSBEiJ_G0021404	protein coding gene	Chr15:80221975-80256005 (+)

Human Ortholog

SYNGR1, synaptogyrin 1

Vertebrate Orthologs

7

Human Ortholog

SYNGR1, synaptogyrin 1
Orthology source: HomoloGene, HGNC
Links

HGNC:11498

NCBI Gene ID: 9145

neXtProt AC: NX_O43759

UniProt: O43759
Chr Location

22q13.1; chr22:39349949-39385588 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 3456
1 human;1 mouse;1 rat;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: SYNGR1
Protein SuperFamily

synaptogyrin
Gene Tree

Syngr1

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References

1 with disease annotations

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
5 phenotypes from multigenic genotypes
29 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

71
Chemically induced (other)

1
Gene trapped

65
Radiation induced

2
Targeted

3
Genomic Mutations

3 involving Syngr1
Incidental Mutations

CvDC
Find Mice (IMSR)

23 strains or lines available

Mice homozygous for a knock-out allele exhibit a moderate decrease in post-tetanic potentiation.

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All GO Annotations

17
GO References

7

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

98
Tissues

49
cDNA Data

17
Literature Summary

3

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase syngr1

ZFIN syngr1a

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Syngr1 interacts with 283 markers (Mir10a, Mir10b, Mir15b, ...) View All

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All Sequences

73
RefSeq

8
UniProt

4
CCDS

CCDS27657.1, CCDS27658.1

Ensembl

ENSMUSG00000022415 (Evidence)
NCBI Gene

20972

			Length	Strain/Species	Flank
genomic	20972	NCBI Gene Model \| MGI Sequence Detail	28168	C57BL/6J	± kb
transcript	NM_207708	RefSeq \| MGI Sequence Detail	4192	Not Specified
polypeptide	O55100	UniProt \| EBI \| MGI Sequence Detail	234	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000015878 synaptogyrin-1

(term hierarchy)
InterPro Domains

IPR008253 Marvel domain

IPR016579 Synaptogyrin

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All nucleic 21

cDNA 18

Other 3

Microarray probesets 7

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MGI:2146324

Summaries

All 59

Developmental Gene Expression 3

Diseases 1

Gene Ontology 7

Phenotypes 29
Earliest

J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
Latest

J:275516 Raja MK, et al., Elevated synaptic vesicle release probability in synaptophysin/gyrin family quadruple knockouts. Elife. 2019 May 15;8

TSS for Syngr1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr132156	Chr15:80091198-80091207 (+)	-131 bp
Tssr132157	Chr15:80091320-80091390 (+)	21 bp
Tssr132158	Chr15:80097866-80097873 (+)	6,536 bp
Tssr132159	Chr15:80098180-80098203 (+)	6,858 bp
Tssr132162	Chr15:80115442-80115488 (+)	24,131 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 10/15/2019 MGI 6.14