Atp6v0e Gene Detail

Summary

• Symbol
  Atp6v0e
• Name
  ATPase, H+ transporting, lysosomal V0 subunit E
• Synonyms
  Atp6k, lysosomal 9kDa, M9.2

• Feature Type
  protein coding gene
• IDs
  MGI:1328318
  NCBI Gene: 11974
• Gene Overview
  MyGene.info: ATP6V0E1
• Alliance
  gene page
• Transcription Start Sites
  3 TSS

Location &
Maps

• Sequence Map
  Chr17:26676396-26699644 bp, + strand
• From Ensembl annotation of GRCm38
  

  View this region in JBrowse
  
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 17, 13.46 cM
• Mapping Data
  1 experiment

Strain
Comparison

• SNPs within 2kb
  263 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1328318	protein coding gene	Chr17:26676396-26699647 (.)
129S1/SvImJ	MGP_129S1SvImJ_G0023404	protein coding gene	Chr17:25868001-25891890 (+)
A/J	MGP_AJ_G0023363	protein coding gene	Chr17:25070148-25093412 (+)
AKR/J	MGP_AKRJ_G0023329	protein coding gene	Chr17:25199207-25225578 (+)
BALB/cJ	MGP_BALBcJ_G0023368	protein coding gene	Chr17:25325042-25348177 (+)
C3H/HeJ	MGP_C3HHeJ_G0023128	protein coding gene	Chr17:25595349-25619386 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0023808	protein coding gene	Chr17:26917154-26947031 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021283	protein coding gene	Chr17:22528011-22551673 (+)
CAST/EiJ	MGP_CASTEiJ_G0022629	protein coding gene	Chr17:25528866-25553414 (+)
CBA/J	MGP_CBAJ_G0023103	protein coding gene	Chr17:27902809-27930260 (+)
DBA/2J	MGP_DBA2J_G0023233	protein coding gene	Chr17:24661205-24684388 (+)
FVB/NJ	MGP_FVBNJ_G0023203	protein coding gene	Chr17:24436565-24460114 (+)
LP/J	MGP_LPJ_G0023310	protein coding gene	Chr17:26130277-26153499 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0023222	protein coding gene	Chr17:27425982-27451749 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023850	protein coding gene	Chr17:25555100-25582821 (+)
PWK/PhJ	MGP_PWKPhJ_G0022378	protein coding gene	Chr17:23456279-23481283 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0022196	protein coding gene	Chr17:23625104-23647253 (+)
WSB/EiJ	MGP_WSBEiJ_G0022692	protein coding gene	Chr17:25605554-25629664 (+)

Homology

• Human Ortholog
  ATP6V0E1, ATPase H+ transporting V0 subunit e1

• Vertebrate Orthologs
  10

• Human Ortholog
  ATP6V0E1, ATPase H+ transporting V0 subunit e1
  Orthology source: HomoloGene, HGNC
• Synonyms
  ATP6H, ATP6V0E, M9.2, Vma21, Vma21p
• Links
  HGNC:863

  NCBI Gene ID: 8992

  neXtProt AC: NX_O15342

  UniProt: O15342

  
  
• Chr Location
  5q35.1; chr5:172983760-173034897 (+)  GRCh38.p7

---

• HomoloGene
  Vertebrate Homology Class 2931
  1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  
• HCOP
  human homology predictions: ATP6V0E1
• Protein SuperFamily
  V-type ATPase, subunits e1/e2
• Gene Tree
  Atp6v0e
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  7 phenotype references
  

• All Mutations and Alleles
  16
• Gene trapped
  13
• Radiation induced
  2
• Targeted
  1
• Genomic Mutations
  2 involving Atp6v0e
• Find Mice (IMSR)
  6 strains or lines available

Gene Ontology
(GO)
Classifications

• All GO Annotations
  11
• GO References
  6

• External Resources
  FuncBase

Expression

• Assay Results
  140
• Tissues
  103
• cDNA Data
  109
• Literature Summary
  3

Images

Tissue x Stage Matrix

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas
• Other Vertebrate Links
  ZFIN atp6v0e1

Interactions

• Atp6v0e interacts with 252 markers (Mir1b, Mir7-1, Mir9-1, ...) View All

Sequences &
Gene Models

• All Sequences
  43
• RefSeq
  2
• UniProt
  2
• CCDS
  CCDS28554.1
• UniGene
  22602

• Ensembl
  ENSMUSG00000015575 (Evidence)
• NCBI Gene
  11974

Representative Sequences			Length	Strain/Species
genomic	ENSMUSG00000015575	Ensembl Gene Model | MGI Sequence Detail	23249	C57BL/6J
transcript	ENSMUST00000167352	Ensembl | MGI Sequence Detail	2812	Not Applicable
polypeptide	ENSMUSP00000127552	Ensembl | MGI Sequence Detail	81	Not Applicable

Protein
Information

• UniProt
  2 Sequences
• Protein Ontology
  PR:000004478 V-type proton ATPase subunit e 1
  (term hierarchy)
• InterPro Domains
  IPR008389 ATPase, V0 complex, subunit e1/e2
  IPR017385 ATPase, V0 complex, subunit e1/e2, metazoa

Molecular
Reagents

• All nucleic 110

  cDNA 110

  
  

  Microarray probesets 3

References

• Summaries
  All 35

  Developmental Gene Expression 3

  Gene Ontology 6

  Phenotypes 7
• Earliest
  J:47435 Ludwig J, et al., Identification and characterization of a novel 9.2-kDa membrane sector-associated protein of vacuolar proton-ATPase from chromaffin granules. J Biol Chem. 1998 May 1;273(18):10939-47
• Latest
  J:194116 Flachs P, et al., Interallelic and intergenic incompatibilities of the Prdm9 (Hst1) gene in mouse hybrid sterility. PLoS Genet. 2012;8(11):e1003044

TSS for Atp6v0e:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr143262	Chr17:26676387-26676388 (+)	-8 bp
Tssr143263	Chr17:26676390-26676401 (+)	0 bp
Tssr143264	Chr17:26676405-26676466 (+)	40 bp