Atp6v0e MGI Mouse Gene Detail - MGI:1328318 - ATPase, H+ transporting, lysosomal V0 subunit E

Symbol

Atp6v0e
Name

ATPase, H+ transporting, lysosomal V0 subunit E
Synonyms

Atp6k, lysosomal 9kDa, M9.2

Feature Type

protein coding gene
IDs

MGI:1328318
NCBI Gene: 11974
Gene Overview

MyGene.info: ATP6V0E1
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr17:26676396-26699644 bp, + strand
From Ensembl annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 13.46 cM
Mapping Data

1 experiment

SNPs within 2kb

263 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1328318	protein coding gene	Chr17:26676396-26699647 (.)
129S1/SvImJ	MGP_129S1SvImJ_G0023404	protein coding gene	Chr17:25868001-25891890 (+)
A/J	MGP_AJ_G0023363	protein coding gene	Chr17:25070148-25093412 (+)
AKR/J	MGP_AKRJ_G0023329	protein coding gene	Chr17:25199207-25225578 (+)
BALB/cJ	MGP_BALBcJ_G0023368	protein coding gene	Chr17:25325042-25348177 (+)
C3H/HeJ	MGP_C3HHeJ_G0023128	protein coding gene	Chr17:25595349-25619386 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0023808	protein coding gene	Chr17:26917154-26947031 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021283	protein coding gene	Chr17:22528011-22551673 (+)
CAST/EiJ	MGP_CASTEiJ_G0022629	protein coding gene	Chr17:25528866-25553414 (+)
CBA/J	MGP_CBAJ_G0023103	protein coding gene	Chr17:27902809-27930260 (+)
DBA/2J	MGP_DBA2J_G0023233	protein coding gene	Chr17:24661205-24684388 (+)
FVB/NJ	MGP_FVBNJ_G0023203	protein coding gene	Chr17:24436565-24460114 (+)
LP/J	MGP_LPJ_G0023310	protein coding gene	Chr17:26130277-26153499 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0023222	protein coding gene	Chr17:27425982-27451749 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023850	protein coding gene	Chr17:25555100-25582821 (+)
PWK/PhJ	MGP_PWKPhJ_G0022378	protein coding gene	Chr17:23456279-23481283 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0022196	protein coding gene	Chr17:23625104-23647253 (+)
WSB/EiJ	MGP_WSBEiJ_G0022692	protein coding gene	Chr17:25605554-25629664 (+)

Human Ortholog

ATP6V0E1, ATPase H+ transporting V0 subunit e1

Vertebrate Orthologs

10

Human Ortholog

ATP6V0E1, ATPase H+ transporting V0 subunit e1
Orthology source: HomoloGene, HGNC
Synonyms

ATP6H, ATP6V0E, M9.2, Vma21, Vma21p
Links

HGNC:863

NCBI Gene ID: 8992

neXtProt AC: NX_O15342

UniProt: O15342
Chr Location

5q35.1; chr5:172983760-173034897 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 2931
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: ATP6V0E1
Protein SuperFamily

V-type ATPase, subunits e1/e2
Gene Tree

Atp6v0e

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Phenotype Summary

7 phenotype references

All Mutations and Alleles

16
Gene trapped

13
Radiation induced

2
Targeted

1
Genomic Mutations

2 involving Atp6v0e
Find Mice (IMSR)

6 strains or lines available

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All GO Annotations

11
GO References

6

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

140
Tissues

103
cDNA Data

109
Literature Summary

3

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN atp6v0e1

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Atp6v0e interacts with 252 markers (Mir1b, Mir7-1, Mir9-1, ...) View All

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All Sequences

43
RefSeq

2
UniProt

2
CCDS

CCDS28554.1
UniGene

22602

Ensembl

ENSMUSG00000015575 (Evidence)
NCBI Gene

11974

			Length	Strain/Species	Flank
genomic	ENSMUSG00000015575	Ensembl Gene Model \| MGI Sequence Detail	23249	C57BL/6J	± kb
transcript	ENSMUST00000167352	Ensembl \| MGI Sequence Detail	2812	Not Applicable
polypeptide	ENSMUSP00000127552	Ensembl \| MGI Sequence Detail	81	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000004478 V-type proton ATPase subunit e 1

(term hierarchy)
InterPro Domains

IPR008389 ATPase, V0 complex, subunit e1/e2

IPR017385 ATPase, V0 complex, subunit e1/e2, metazoa

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All nucleic 110

cDNA 110

Microarray probesets 3

Summaries

All 35

Developmental Gene Expression 3

Gene Ontology 6

Phenotypes 7
Earliest

J:47435 Ludwig J, et al., Identification and characterization of a novel 9.2-kDa membrane sector-associated protein of vacuolar proton-ATPase from chromaffin granules. J Biol Chem. 1998 May 1;273(18):10939-47
Latest

J:194116 Flachs P, et al., Interallelic and intergenic incompatibilities of the Prdm9 (Hst1) gene in mouse hybrid sterility. PLoS Genet. 2012;8(11):e1003044

TSS for Atp6v0e:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr143262	Chr17:26676387-26676388 (+)	-8 bp
Tssr143263	Chr17:26676390-26676401 (+)	0 bp
Tssr143264	Chr17:26676405-26676466 (+)	40 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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