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Chkb
Gene Detail
Symbol

Name
ID
Chkb
choline kinase beta
MGI:1328313
Synonyms
Chetk, Chkl, CK/EK-beta
Feature Type
protein coding gene
Genetic Map
Chromosome 15
44.89 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr15:89416405-89429908 bp, - strand
From VEGA annotation of GRCm38

  13504 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:88718  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: CHKB
Gene Tree: Chkb

Human
homologs
CHKB, choline kinase beta
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 1120
neXtProt AC: NX_Q9Y259

Human Synonyms: CHETK, CHKL, CK, CKB, CKEKB, EK, EKB, MDCMC

Human Chr (Location): 22q13.33; chr22:50578958-50582999 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human CHKB

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Chemically induced (ENU)(1) Radiation induced(1) Spontaneous(1)
Genomic Mutations involving Chkb (1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice display progressive muscular weakness and dystrophy in the hindlimbs but have normal nerve and neuromuscular junction morphology.
 
Human Diseases Modeled in Mice Using Chkb (1)    Mutations Annotated to Human Diseases (1)    Phenotype Images(5)
Interactions
Chkb interacts with 45 markers (Mir15a, Mir18, Mir92-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process CDP-choline pathway, lipid metabolic process, ...
Function ATP binding, choline kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (94)    Tissues (94)    Images (15)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 94
cDNA source data(62)
Other mouse links: GEO   Expression Atlas
Other vertebrate links: Xenbase chkb ; ZFIN chkb    NEW 
Molecular
reagents
All nucleic(64) Genomic(2) cDNA(62)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000035435 (Evidence)
Ensembl Gene Model ENSMUSG00000022617 (Evidence)
Entrez Gene 12651 (Evidence)
UniGene 485045
EC 2.7.1.82, 2.7.1.32
Consensus CDS Project CCDS27750.1
International Mouse Phenotyping Consortium Status Chkb
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035435 VEGA Gene Model | MGI Sequence Detail 13504 C57BL/6J ±  kb
transcript OTTMUST00000090614 VEGA | MGI Sequence Detail 1707 Not Applicable 
polypeptide OTTMUSP00000049745 VEGA | MGI Sequence Detail 394 Not Applicable 

For the selected sequences
All sequences(49) RefSeq(4) UniProt(5)
Polymorphisms
SNPs within 2kb(16 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011009 Protein kinase-like domain
Protein Ontology PR:000005428 choline/ethanolamine kinase
References
(Earliest) J:49279 Aoyama C, et al., Molecular cloning of mouse choline kinase and choline/ethanolamine kinase: their sequence comparison to the respective rat homologs. Biochim Biophys Acta. 1998 Jul 31;1393(1):179-85
(Latest) J:212488 Li Z, et al., Choline kinase beta is required for normal endochondral bone formation. Biochim Biophys Acta. 2014 Jul;1840(7):2112-22
All references(31)
Disease annotation references (1)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory