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Chkb
Gene Detail
 Symbol
Name
ID
Chkb
choline kinase beta
MGI:1328313
Synonyms Chetk, Chkl, CK/EK-beta
Feature Type protein coding gene
Genetic Map
Chromosome 15
44.89 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr15:89416405-89429908 bp, - strand
From VEGA annotation of GRCm38

  13504 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:88718  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Gene Tree: Chkb

Human
homologs
Human Homolog CHKB, choline kinase beta
NCBI Gene ID 1120
neXtProt AC  NX_Q9Y259
Human Synonyms  CHETK, CHKL, CK, CKB, CKEKB, EK, EKB, MDCMC
Human Chr (Location)  22q13.33; chr22:50578958-50582999 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human CHKB
Alleles
and
phenotypes
All alleles(2) : Chemically induced (ENU)(1) Spontaneous(1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice display progressive muscular weakness and dystrophy in the hindlimbs but have normal nerve and neuromuscular junction morphology.
 
Human Diseases Modeled Using Mouse Chkb (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(3)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process CDP-choline pathway, lipid metabolic process, ...
Function ATP binding, choline kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (94)    Tissues (94)    Images (15)
Theiler Stages: 22
Assay TypeResults
RNA in situ 94
cDNA source data(62)
External Resources: GEO   ArrayExpress
Molecular
reagents
All nucleic(64) Genomic(2) cDNA(62)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000035435 (Evidence)
Ensembl Gene ModelENSMUSG00000022617 (Evidence)
Entrez Gene12651 (Evidence)
UniGene485045
EC2.7.1.32, 2.7.1.82
Consensus CDS ProjectCCDS27750.1
International Mouse Knockout Project StatusChkb
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035435 VEGA Gene Model | MGI Sequence Detail 13504 C57BL/6J ±  kb
transcript OTTMUST00000090614 VEGA | MGI Sequence Detail 1707 Not Applicable 
polypeptide OTTMUSP00000049745 VEGA | MGI Sequence Detail 394 Not Applicable 

For the selected sequences
All sequences(49) RefSeq(4) UniProt(5)
Polymorphisms SNPs within 2kb(16 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011009 Protein kinase-like domain
Protein Ontology PR:000005428 choline/ethanolamine kinase
References (Earliest) J:49279 Aoyama C, et al., Molecular cloning of mouse choline kinase and choline/ethanolamine kinase: their sequence comparison to the respective rat homologs. Biochim Biophys Acta. 1998 Jul 31;1393(1):179-85
(Latest) J:178043 Mitsuhashi S, et al., A congenital muscular dystrophy with mitochondrial structural abnormalities caused by defective de novo phosphatidylcholine biosynthesis. Am J Hum Genet. 2011 Jun 10;88(6):845-51
All references(31)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory