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Orc2 Gene Detail
Summary
  • Symbol
    Orc2
  • Name
    origin recognition complex, subunit 2
  • Synonyms
    Orc2l
  • Feature Type
    protein coding gene
  • IDs
    MGI:1328306
    NCBI Gene: 18393
  • Gene Overview
    MyGene.info: ORC2
Location & Maps
more
  • Sequence Map
    Chr1:58462771-58505109 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      42339 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    ORC2, origin recognition complex subunit 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ORC2, origin recognition complex subunit 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ORC2L
  • Links
    NCBI Gene ID: 4999
    neXtProt AC: NX_Q13416

  • Chr Location
    2q33; chr2:200910171-200963703 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 4512
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: ORC2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotype references
  • All Mutations and Alleles
    29
  • Chemically induced (other)
    1
  • Gene trapped
    25
  • Radiation induced
    1
  • Targeted
    2
  • Genomic Mutations
    2 involving Orc2
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021969 VEGA Gene Model | MGI Sequence Detail 42339 C57BL/6J ±  kb
transcript OTTMUST00000052154 VEGA | MGI Sequence Detail 3561 Not Applicable  
polypeptide OTTMUSP00000024670 VEGA | MGI Sequence Detail 576 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    121 from dbSNP Build 142
Protein
Information
less
  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000012031 origin recognition complex subunit 2
  • InterPro Domains
    IPR007220 Origin recognition complex, subunit 2
Molecular
Reagents
less
  • All nucleic 103
    cDNA 103

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-32127, MGI:105087, MGI:2138491
References
more
  • Summaries
    All 40
    Developmental Gene Expression 3
    Gene Ontology 7
    Phenotypes 11
  • Earliest
    J:30882 Takahara K, et al., Mouse and human homologues of the yeast origin of replication recognition complex subunit ORC2 and chromosomal localization of the cognate human gene ORC2L. Genomics. 1996 Jan 1;31(1):119-22
  • Latest
    J:192413 Ortega MA, et al., Unique pattern of ORC2 and MCM7 localization during DNA replication licensing in the mouse zygote. Biol Reprod. 2012 Sep;87(3):62

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory