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Orc2
Gene Detail
Symbol

Name
ID
Orc2
origin recognition complex, subunit 2
MGI:1328306
Synonyms
Orc2l
Feature Type
protein coding gene
Genetic Map
Chromosome 1
29.10 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr1:58462771-58505109 bp, - strand
From VEGA annotation of GRCm38

  42339 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4512  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: ORC2
Gene Tree: Orc2

Human
homologs
ORC2, origin recognition complex, subunit 2
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 4999
neXtProt AC: NX_Q13416

Human Synonyms: ORC2L

Human Chr (Location): 2q33; chr2:200910171-200963703 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(27) : Gene trapped(25) Targeted(2)
Incidental mutations (data from Mutagenetix , APF , CvDC )
Interactions
Orc2 interacts with 225 markers (Mir16-2, Mir17, Mir20a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process DNA replication
Component centrosome, chromatin, ...
Function DNA replication origin binding
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (17)    Tissues (17)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 5
Northern blot 12
cDNA source data(102)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase orc2    NEW 
Molecular
reagents
All nucleic(103) cDNA(103)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000021969 (Evidence)
Ensembl Gene Model ENSMUSG00000026037 (Evidence)
Entrez Gene 18393 (Evidence)
UniGene 3411
DFCI TC1574371, TC1677121
NIA Mouse Gene Index U021357
Consensus CDS Project CCDS14974.1, CCDS14975.1
International Mouse Phenotyping Consortium Status Orc2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021969 VEGA Gene Model | MGI Sequence Detail 42339 C57BL/6J ±  kb
transcript OTTMUST00000052154 VEGA | MGI Sequence Detail 3561 Not Applicable 
polypeptide OTTMUSP00000024670 VEGA | MGI Sequence Detail 576 Not Applicable 

For the selected sequences
All sequences(59) RefSeq(8) UniProt(5)
Polymorphisms
SNPs within 2kb(122 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007220 Origin recognition complex, subunit 2
Protein Ontology PR:000012031 origin recognition complex subunit 2
References
(Earliest) J:30882 Takahara K, et al., Mouse and human homologues of the yeast origin of replication recognition complex subunit ORC2 and chromosomal localization of the cognate human gene ORC2L. Genomics. 1996 Jan 1;31(1):119-22
(Latest) J:192413 Ortega MA, et al., Unique pattern of ORC2 and MCM7 localization during DNA replication licensing in the mouse zygote. Biol Reprod. 2012 Sep;87(3):62
All references(42)
Other
accession IDs
MGD-MRK-32127, MGI:105087, MGI:2138491

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory