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Ly86
Gene Detail
Symbol

Name
ID
Ly86
lymphocyte antigen 86
MGI:1321404
Synonyms
MD1, MD-1
Feature Type
protein coding gene
Genetic Map
Chromosome 13
14.70 cM
Detailed Genetic Map ± 1 cM

Sequence Map
Chr13:37345345-37419036 bp, + strand
From NCBI annotation of GRCm38

  73692 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:48274  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

HCOP human homology predictions: LY86
Gene Tree: Ly86

Human
homologs
LY86, lymphocyte antigen 86
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 9450
neXtProt AC: NX_O95711

Human Synonyms: dJ80N2.1, MD1, MD-1, MMD-1

Human Chr (Location): 6p25.1; chr6:6588701-6654983 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele display impaired LPS-induced B-cell proliferation and antibody production.
 
Interactions
Ly86 interacts with 45 markers (Mir19a, Mir27a, Mir28b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (7 annotations)
Process immune system process, inflammatory response, ...
Component extracellular region
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (18)    Tissues (15)    Images (9)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 18
cDNA source data(31)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: ZFIN ly86    NEW 
Molecular
reagents
All nucleic(32) cDNA(31) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000021423 (Evidence)
Entrez Gene 17084 (Evidence)
UniGene 2639
DFCI TC1582935
DoTS DT.50316172, DT.102555145
NIA Mouse Gene Index U014730
PDB 3M7O, 3T6Q
Consensus CDS Project CCDS26457.1
International Mouse Phenotyping Consortium Status Ly86
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 17084 NCBI Gene Model | MGI Sequence Detail 73692 C57BL/6J ±  kb
transcript NM_010745 RefSeq | MGI Sequence Detail 997 Not Specified 
polypeptide O88188 UniProt | EBI | MGI Sequence Detail 162 Not Applicable 

For the selected sequences
All sequences(16) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(830 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR014756 Immunoglobulin E-set
InterPro IPR003172 MD-2-related lipid-recognition (ML) domain
Protein Ontology PR:000009997 lymphocyte antigen 86
Graphical View of Protein Domain Structure
References
(Earliest) J:48825 Miyake K, et al., Mouse MD-1, a molecule that is physically associated with RP105 and positively regulates its expression. J Immunol. 1998 Aug 1;161(3):1348-53
(Latest) J:181374 Sasaki S, et al., Serum soluble MD-1 levels increase with disease progression in autoimmune prone MRL(lpr/lpr) mice. Mol Immunol. 2012 Jan;49(4):611-20
All references(32)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory