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Ly86 Gene Detail
Summary
  • Symbol
    Ly86
  • Name
    lymphocyte antigen 86
  • Synonyms
    MD1, MD-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1321404
    NCBI Gene: 17084
Location & Maps
more
  • Sequence Map
    Chr13:37345345-37419036 bp, + strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      73692 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    LY86, lymphocyte antigen 86
  • Vertebrate Orthologs
    9
  • Human Ortholog
    LY86, lymphocyte antigen 86
    Orthology source: HGNC, HomoloGene
  • Synonyms
    dJ80N2.1, MD1, MD-1, MMD-1
  • Links
    NCBI Gene ID: 9450
    neXtProt AC: NX_O95711

  • Chr Location
    6p25.1; chr6:6588701-6654983 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    3
  • Chemically induced (other)
    1
  • Targeted
    2
  • Genomic Mutations
    1 involving Ly86
  • Incidental Mutations
Mice homozygous for a knock-out allele display impaired LPS-induced B-cell proliferation and antibody production.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 17084 NCBI Gene Model | MGI Sequence Detail 73692 C57BL/6J ±  kb
transcript NM_010745 RefSeq | MGI Sequence Detail 997 Not Specified  
polypeptide O88188 UniProt | EBI | MGI Sequence Detail 162 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    818 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 32
    cDNA 31
    Other 1

    Microarray probesets 3
References
more
  • Summaries
    All 30
    Developmental Gene Expression 3
    Gene Ontology 2
    Phenotypes 10
  • Earliest
    J:48825 Miyake K, et al., Mouse MD-1, a molecule that is physically associated with RP105 and positively regulates its expression. J Immunol. 1998 Aug 1;161(3):1348-53
  • Latest
    J:217629 Kunda PE, et al., Lipopolysaccharides and trophic factors regulate the LPS receptor complex in nodose and trigeminal neurons. Neuroscience. 2014 Nov 7;280:60-72

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory