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Lcp2
Gene Detail
Symbol

Name
ID
Lcp2
lymphocyte cytosolic protein 2
MGI:1321402
Synonyms
SLP76, SLP-76, twm
Feature Type
protein coding gene
Genetic Map
Chromosome 11
19.43 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr11:34046920-34092295 bp, + strand
From VEGA annotation of GRCm38

  45376 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4065  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: LCP2
Gene Tree: Lcp2

Human
homologs
LCP2, lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 3937
neXtProt AC: NX_Q13094

Human Synonyms: SLP76, SLP-76

Human Chr (Location): 5q35.1; chr5:170247754-170297818 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Chemically induced (ENU)(1) Targeted(10)
Incidental mutations (data from Mutagenetix , APF )
 
T cell development is blocked and T cell receptor signaling impaired in homozygous point mutants. Double positive thymocyte and single positive T cell numbers are much reduced. Both positive and negative thymocyte selection is abnormal. Mice have high IgG and IgE levels and exhibit autoimmunity.
 
Interactions
Lcp2 interacts with 241 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process cytokine secretion, immune response, ...
Component cell, cell-cell junction, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (5)    Tissues (1)    Images (5)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 5
cDNA source data(34)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase lcp2    NEW 
Molecular
reagents
All nucleic(37) cDNA(37)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000005404 (Evidence)
Ensembl Gene Model ENSMUSG00000002699 (Evidence)
Entrez Gene 16822 (Evidence)
UniGene 265350
DFCI TC1592180, TC1576580, TC1595244
DoTS DT.91551537, DT.490269
NIA Mouse Gene Index U012450
PDB 1OEB, 2EU0, 2ETZ
Consensus CDS Project CCDS48768.1
International Mouse Phenotyping Consortium Status Lcp2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005404 VEGA Gene Model | MGI Sequence Detail 45376 C57BL/6J ±  kb
transcript OTTMUST00000012047 VEGA | MGI Sequence Detail 3647 Not Applicable 
polypeptide OTTMUSP00000005584 VEGA | MGI Sequence Detail 534 Not Applicable 

For the selected sequences
All sequences(38) RefSeq(2) UniProt(4)
Polymorphisms
SNPs within 2kb(141 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000980 SH2 domain
InterPro IPR001660 Sterile alpha motif domain
InterPro IPR013761 Sterile alpha motif/pointed domain
InterPro IPR011510 Sterile alpha motif, type 2
Protein Ontology PR:000009733 lymphocyte cytosolic protein 2
References
(Earliest) J:24168 Jackman JK, et al., Molecular cloning of SLP-76, a 76-kDa tyrosine phosphoprotein associated with Grb2 in T cells. J Biol Chem. 1995 Mar 31;270(13):7029-32
(Latest) J:221518 Carty SA, et al., Interleukin-4 regulates eomesodermin in CD8+ T cell development and differentiation. PLoS One. 2014;9(9):e106659
All references(100)
Other
accession IDs
MGI:2144122, MGI:2144608, MGI:3584401

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory