Lcp2 MGI Mouse Gene Detail - MGI:1321402 - lymphocyte cytosolic protein 2

Symbol

Lcp2
Name

lymphocyte cytosolic protein 2
Synonyms

m1Khoe, SLP76, SLP-76, twm

Feature Type

protein coding gene
IDs

MGI:1321402
NCBI Gene: 16822
Gene Overview

MyGene.info: LCP2
Alliance

gene page
Transcription Start Sites

12 TSS

Sequence Map

Chr11:34046928-34092281 bp, + strand
From NCBI annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 19.43 cM
Mapping Data

2 experiments

SNPs within 2kb

140 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1321402	protein coding gene	Chr11:34046920-34092295 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018149	protein coding gene	Chr11:32374050-32420991 (+)
A/J	MGP_AJ_G0018122	protein coding gene	Chr11:31145550-31190874 (+)
AKR/J	MGP_AKRJ_G0018086	protein coding gene	Chr11:32115938-32161155 (+)
BALB/cJ	MGP_BALBcJ_G0018091	protein coding gene	Chr11:31327804-31373610 (+)
C3H/HeJ	MGP_C3HHeJ_G0017904	protein coding gene	Chr11:32066482-32112294 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018545	protein coding gene	Chr11:33412156-33457360 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016200	protein coding gene	Chr11:29640320-29685350 (+)
CAST/EiJ	MGP_CASTEiJ_G0017468	protein coding gene	Chr11:32172132-32218597 (+)
CBA/J	MGP_CBAJ_G0017877	protein coding gene	Chr11:35074307-35124027 (+)
DBA/2J	MGP_DBA2J_G0017987	protein coding gene	Chr11:30912178-30957477 (+)
FVB/NJ	MGP_FVBNJ_G0017981	protein coding gene	Chr11:30743731-30789714 (+)
LP/J	MGP_LPJ_G0018059	protein coding gene	Chr11:32646511-32691801 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018005	protein coding gene	Chr11:35966157-36013090 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018584	protein coding gene	Chr11:32275252-32320511 (+)
PWK/PhJ	MGP_PWKPhJ_G0017249	protein coding gene	Chr11:31106659-31172295 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017041	protein coding gene	Chr11:32005988-32073608 (+)
WSB/EiJ	MGP_WSBEiJ_G0017517	protein coding gene	Chr11:31911914-31957093 (+)

Human Ortholog

LCP2, lymphocyte cytosolic protein 2

Vertebrate Orthologs

11

Human Ortholog

LCP2, lymphocyte cytosolic protein 2
Orthology source: HomoloGene, HGNC
Synonyms

SLP76, SLP-76
Links

HGNC:6529

NCBI Gene ID: 3937

neXtProt AC: NX_Q13094

UniProt: Q13094
Chr Location

5q35.1; chr5:170248084-170297818 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 4065
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: LCP2
Gene Tree

Lcp2

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Phenotype Summary

48 phenotypes from 10 alleles in 10 genetic backgrounds
24 phenotypes from multigenic genotypes
76 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

14
Chemically induced (ENU)

2
Chemically induced (other)

1
Targeted

11
Genomic Mutations

1 involving Lcp2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

31 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

T cell development is blocked and T cell receptor signaling impaired in homozygous point mutants. Double positive thymocyte and single positive T cell numbers are much reduced. Both positive and negative thymocyte selection is abnormal. Mice have high IgG and IgE levels and exhibit autoimmunity.

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All GO Annotations

16
GO References

10

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

636
Tissues

1
cDNA Data

35
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase lcp2

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Lcp2 interacts with 241 markers (Mir1a-1, Mir1a-2, Mir1b, ...) View All

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All Sequences

40
RefSeq

2
UniProt

3
CCDS

CCDS48768.1
UniGene

265350

Ensembl

ENSMUSG00000002699 (Evidence)
NCBI Gene

16822

			Length	Strain/Species	Flank
genomic	16822	NCBI Gene Model \| MGI Sequence Detail	45354	C57BL/6J	± kb
transcript	NM_010696	RefSeq \| MGI Sequence Detail	3622	C57BL/6
polypeptide	Q60787	UniProt \| EBI \| MGI Sequence Detail	533	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000009733 lymphocyte cytosolic protein 2

(term hierarchy)
PDB

1OEB, 2ETZ, 2EU0
InterPro Domains

IPR000980 SH2 domain

IPR036860 SH2 domain superfamily

IPR001660 Sterile alpha motif domain

IPR013761 Sterile alpha motif/pointed domain superfamily

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All nucleic 38

cDNA 38

Microarray probesets 4

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MGI:2144122, MGI:2144608, MGI:3584401, MGI:5491499

Summaries

All 122

Developmental Gene Expression 2

Gene Ontology 10

Phenotypes 76
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:300870 Yan Z, et al., Targeting adaptor protein SLP76 of RAGE as a therapeutic approach for lethal sepsis. Nat Commun. 2021 Jan 12;12(1):308

TSS for Lcp2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr100891	Chr11:34046922-34046958 (+)	12 bp
Tssr100892	Chr11:34047078-34047093 (+)	158 bp
Tssr100893	Chr11:34047115-34047242 (+)	251 bp
Tssr100894	Chr11:34047243-34047257 (+)	322 bp
Tssr100895	Chr11:34047290-34047299 (+)	367 bp
Tssr100896	Chr11:34047321-34047326 (+)	396 bp
Tssr100897	Chr11:34047646-34047657 (+)	724 bp
Tssr100910	Chr11:34078110-34078119 (+)	31,187 bp
Tssr100911	Chr11:34078123-34078135 (+)	31,201 bp
Tssr100912	Chr11:34078155-34078162 (+)	31,231 bp
Tssr100913	Chr11:34078169-34078181 (+)	31,247 bp
Tssr100914	Chr11:34078503-34078514 (+)	31,581 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 02/16/2021 MGI 6.16