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Lcp2
Gene Detail
Symbol

Name
ID
Lcp2
lymphocyte cytosolic protein 2
MGI:1321402
Synonyms
SLP76, SLP-76, twm
Feature Type
protein coding gene
Genetic Map
Chromosome 11
19.43 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr11:34046920-34092295 bp, + strand
From VEGA annotation of GRCm38

  45376 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4065  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Gene Tree: Lcp2

Human
homologs
Human Homolog LCP2, lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
NCBI Gene ID 3937
neXtProt AC  NX_Q13094
Human Synonyms  SLP76, SLP-76
Human Chr (Location)  5q35.1; chr5:170248084-170297818 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Chemically induced (ENU)(1) Targeted(9)
Incidental mutations (data from Mutagenetix , APF )
 
T cell development is blocked and T cell receptor signaling impaired in homozygous point mutants. Double positive thymocyte and single positive T cell numbers are much reduced. Both positive and negative thymocyte selection is abnormal. Mice have high IgG and IgE levels and exhibit autoimmunity.
 
Interactions
Lcp2 interacts with 242 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (5 annotations)
Process cytokine secretion, mast cell activation
Component cell, cell-cell junction, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (5)    Tissues (1)    Images (5)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 5
cDNA source data(34)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(37) cDNA(37)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000005404 (Evidence)
Ensembl Gene ModelENSMUSG00000002699 (Evidence)
Entrez Gene16822 (Evidence)
UniGene265350
DFCITC1592180, TC1576580, TC1595244
DoTSDT.91551537, DT.490269
NIA Mouse Gene IndexU012450
PDB1OEB, 2ETZ, 2EU0
Consensus CDS ProjectCCDS48768.1
International Mouse Knockout Project StatusLcp2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005404 VEGA Gene Model | MGI Sequence Detail 45376 C57BL/6J ±  kb
transcript OTTMUST00000012047 VEGA | MGI Sequence Detail 3647 Not Applicable 
polypeptide OTTMUSP00000005584 VEGA | MGI Sequence Detail 534 Not Applicable 

For the selected sequences
All sequences(41) RefSeq(2) UniProt(7)
Polymorphisms
SNPs within 2kb(141 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000980 SH2 domain
InterPro IPR001660 Sterile alpha motif domain
InterPro IPR013761 Sterile alpha motif/pointed domain
InterPro IPR011510 Sterile alpha motif, type 2
Protein Ontology PR:000009733 lymphocyte cytosolic protein 2
References
(Earliest) J:24168 Jackman JK, et al., Molecular cloning of SLP-76, a 76-kDa tyrosine phosphoprotein associated with Grb2 in T cells. J Biol Chem. 1995 Mar 31;270(13):7029-32
(Latest) J:209305 Caton AJ, et al., Strength of TCR signal from self-peptide modulates autoreactive thymocyte deletion and Foxp3(+) Treg-cell formation. Eur J Immunol. 2014 Mar;44(3):785-93
All references(97)
Other
accession IDs
MGI:2144122, MGI:2144608, MGI:3584401

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory