About   Help   FAQ
Lcp2 Gene Detail
Summary
  • Symbol
    Lcp2
  • Name
    lymphocyte cytosolic protein 2
  • Synonyms
    m1Khoe, SLP76, SLP-76, twm
  • Feature Type
    protein coding gene
  • IDs
    MGI:1321402
    NCBI Gene: 16822
  • Gene Overview
    MyGene.info: LCP2
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr11:34046920-34092295 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      45376 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 19.43 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    LCP2, lymphocyte cytosolic protein 2
  • Vertebrate Orthologs
    11
  • Human Ortholog
    LCP2, lymphocyte cytosolic protein 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    SLP76, SLP-76
  • Links
    NCBI Gene ID: 3937
    neXtProt AC: NX_Q13094
    UniProt: Q13094

  • Chr Location
    5q35.1; chr5:170248084-170297818 (-)  GRCh38.p7
  • HomoloGene
    Vertebrate Homology Class 4065
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: LCP2
  • Gene Tree
    Lcp2
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    39 phenotypes from 9 alleles in 9 genetic backgrounds
    24 phenotypes from multigenic genotypes
    72 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
T cell development is blocked and T cell receptor signaling impaired in homozygous point mutants. Double positive thymocyte and single positive T cell numbers are much reduced. Both positive and negative thymocyte selection is abnormal. Mice have high IgG and IgE levels and exhibit autoimmunity.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    5
  • Tissues
    1
  • cDNA Data
    34
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000005404 VEGA Gene Model | MGI Sequence Detail 45376 C57BL/6J ±  kb
    transcript OTTMUST00000012047 VEGA | MGI Sequence Detail 3644 Not Applicable  
    polypeptide OTTMUSP00000005584 VEGA | MGI Sequence Detail 533 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      140 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 37
      cDNA 37

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2144122, MGI:2144608, MGI:3584401, MGI:5491499
    References
    more
    • Summaries
      All 119
      Developmental Gene Expression 2
      Gene Ontology 10
      Phenotypes 72
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:246908 Navas VH, et al., Serine Phosphorylation of SLP76 Is Dispensable for T Cell Development but Modulates Helper T Cell Function. PLoS One. 2017;12(1):e0170396
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.     		last database update
    06/12/2018
    MGI 6.12     		The Jackson Laboratory