Lcp2 MGI Mouse Gene Detail - MGI:1321402 - lymphocyte cytosolic protein 2

Lcp2 Gene Detail

Symbol

Lcp2
Name

lymphocyte cytosolic protein 2
Synonyms

m1Khoe, SLP76, SLP-76, twm

Feature Type

protein coding gene
IDs

MGI:1321402
NCBI Gene: 16822
Gene Overview

MyGene.info: LCP2

Sequence Map

Chr11:34046920-34092295 bp, + strand
From VEGA annotation of GRCm38

Mouse Genome Browser
Download
Sequence

45376 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 19.43 cM
Mapping Data

2 experiments

Human Ortholog

LCP2, lymphocyte cytosolic protein 2

Vertebrate Orthologs

11

Human Ortholog

LCP2, lymphocyte cytosolic protein 2
Orthology source: HomoloGene, HGNC
Synonyms

SLP76, SLP-76
Links

HGNC:6529

NCBI Gene ID: 3937

neXtProt AC: NX_Q13094

UniProt: Q13094
Chr Location

5q35.1; chr5:170248084-170297818 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 4065
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: LCP2
Gene Tree

Lcp2

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Phenotype Summary

39 phenotypes from 9 alleles in 9 genetic backgrounds
24 phenotypes from multigenic genotypes
72 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

14
Chemically induced (ENU)

2
Chemically induced (other)

1
Targeted

11
Genomic Mutations

1 involving Lcp2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

30 strains or lines available

T cell development is blocked and T cell receptor signaling impaired in homozygous point mutants. Double positive thymocyte and single positive T cell numbers are much reduced. Both positive and negative thymocyte selection is abnormal. Mice have high IgG and IgE levels and exhibit autoimmunity.

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All GO Annotations

17
GO References

10

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

5
Tissues

1
cDNA Data

34
Literature Summary

2

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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Lcp2 interacts with 241 markers (Mir1a-1, Mir1a-2, Mir1b, ...) View All

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All Sequences

29
RefSeq

2
UniProt

3
CCDS

CCDS48768.1
UniGene

265350

			Length	Strain/Species	Flank
genomic	OTTMUSG00000005404	VEGA Gene Model \| MGI Sequence Detail	45376	C57BL/6J	± kb
transcript	OTTMUST00000012047	VEGA \| MGI Sequence Detail	3644	Not Applicable
polypeptide	OTTMUSP00000005584	VEGA \| MGI Sequence Detail	533	Not Applicable

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SNPs within 2kb

140 from dbSNP Build 142

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UniProt

3 Sequences
Protein Ontology

PR:000009733 lymphocyte cytosolic protein 2

(term hierarchy)
PDB

1OEB, 2ETZ, 2EU0
InterPro Domains

IPR000980 SH2 domain

IPR001660 Sterile alpha motif domain

IPR013761 Sterile alpha motif/pointed domain

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All nucleic 37

cDNA 37

Microarray probesets 4

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MGI:2144122, MGI:2144608, MGI:3584401, MGI:5491499

Summaries

All 112

Developmental Gene Expression 2

Gene Ontology 10

Phenotypes 72
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:237276 Reppschlager K, et al., TULA-2 Protein Phosphatase Suppresses Activation of Syk through the GPVI Platelet Receptor for Collagen by Dephosphorylating Tyr(P)346, a Regulatory Site of Syk. J Biol Chem. 2016 Oct 21;291(43):22427-22441

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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