Lcp2
Gene Detail

Symbol Name ID

Lcp2 lymphocyte cytosolic protein 2 MGI:1321402

Synonyms

SLP76, SLP-76, twm

Feature Type

protein coding gene

Genetic Map

Chromosome 11

19.43 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr11:34046920-34092295 bp, + strand From VEGA annotation of GRCm38   45376 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:4065  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Gene Tree: Lcp2

Human homologs

Human Homolog		LCP2, lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
NCBI Gene ID		3937
neXtProt AC		NX_Q13094
Human Synonyms		SLP76, SLP-76
Human Chr (Location)		5q35.1; chr5:170248084-170297818 (-)  GRCh38

Alleles and phenotypes

All alleles(10) : Chemically induced (ENU)(1) Targeted(9)
Incidental mutations (data from Mutagenetix , APF )
 

T cell development is blocked and T cell receptor signaling impaired in homozygous point mutants. Double positive thymocyte and single positive T cell numbers are much reduced. Both positive and negative thymocyte selection is abnormal. Mice have high IgG and IgE levels and exhibit autoimmunity.

 

Gene Ontology (GO) classifications

All GO classifications: (5 annotations)

Process	cytokine secretion, mast cell activation
Component	cell, cell-cell junction, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)

Data Summary: Results (5)    Tissues (1)    Images (5)
Theiler Stages: 23

Assay Type	Results
RNA in situ	5

cDNA source data(34)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(37) cDNA(37)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000005404 (Evidence)
Ensembl Gene Model	ENSMUSG00000002699 (Evidence)
Entrez Gene	16822 (Evidence)
UniGene	265350
DFCI	TC1576580, TC1592180, TC1595244
DoTS	DT.490269, DT.91551537
NIA Mouse Gene Index	U012450
PDB	1OEB, 2ETZ, 2EU0
Consensus CDS Project	CCDS48768.1
International Mouse Knockout Project Status	Lcp2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000005404	VEGA Gene Model | MGI Sequence Detail	45376	C57BL/6J
transcript	OTTMUST00000012047	VEGA | MGI Sequence Detail	3647	Not Applicable
polypeptide	OTTMUSP00000005584	VEGA | MGI Sequence Detail	534	Not Applicable

All sequences(38) RefSeq(2) UniProt(4)

Polymorphisms

SNPs within 2kb(141 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR000980	SH2 domain
InterPro	IPR001660	Sterile alpha motif domain
InterPro	IPR013761	Sterile alpha motif/pointed domain
InterPro	IPR011510	Sterile alpha motif, type 2
Protein Ontology	PR:000009733	lymphocyte cytosolic protein 2

References

(Earliest) J:24168 Jackman JK, et al., Molecular cloning of SLP-76, a 76-kDa tyrosine phosphoprotein associated with Grb2 in T cells. J Biol Chem. 1995 Mar 31;270(13):7029-32
(Latest) J:209305 Caton AJ, et al., Strength of TCR signal from self-peptide modulates autoreactive thymocyte deletion and Foxp3(+) Treg-cell formation. Eur J Immunol. 2014 Mar;44(3):785-93
All references(97)

Other accession IDs

MGI:2144122, MGI:2144608, MGI:3584401