T cell development is blocked and T cell receptor signaling impaired in homozygous point mutants. Double positive thymocyte and single positive T cell numbers are much reduced. Both positive and negative thymocyte selection is abnormal. Mice have high IgG and IgE levels and exhibit autoimmunity.
|VEGA Gene Model||OTTMUSG00000005404 (Evidence)|
|Ensembl Gene Model||ENSMUSG00000002699 (Evidence)|
|Entrez Gene||16822 (Evidence)|
|DFCI||TC1592180, TC1576580, TC1595244|
|NIA Mouse Gene Index||U012450|
|PDB||1OEB, 2EU0, 2ETZ|
|Consensus CDS Project||CCDS48768.1|
|International Mouse Phenotyping Consortium Status||Lcp2|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update