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Lcp2 Gene Detail
Summary
  • Symbol
    Lcp2
  • Name
    lymphocyte cytosolic protein 2
  • Synonyms
    m1Khoe, SLP76, SLP-76, twm
  • Feature Type
    protein coding gene
  • IDs
    MGI:1321402
    NCBI Gene: 16822
  • Gene Overview
    MyGene.info: LCP2
  • Alliance
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:34047201-34092280 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 19.43 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    139 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1321402
protein coding gene Chr11:34046920-34092295 (.)
129S1/SvImJ MGP_129S1SvImJ_G0018149
protein coding gene Chr11:32374050-32420991 (+)
A/J MGP_AJ_G0018122
protein coding gene Chr11:31145550-31190874 (+)
AKR/J MGP_AKRJ_G0018086
protein coding gene Chr11:32115938-32161155 (+)
BALB/cJ MGP_BALBcJ_G0018091
protein coding gene Chr11:31327804-31373610 (+)
C3H/HeJ MGP_C3HHeJ_G0017904
protein coding gene Chr11:32066482-32112294 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018545
protein coding gene Chr11:33412156-33457360 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016200
protein coding gene Chr11:29640320-29685350 (+)
CAST/EiJ MGP_CASTEiJ_G0017468
protein coding gene Chr11:32172132-32218597 (+)
CBA/J MGP_CBAJ_G0017877
protein coding gene Chr11:35074307-35124027 (+)
DBA/2J MGP_DBA2J_G0017987
protein coding gene Chr11:30912178-30957477 (+)
FVB/NJ MGP_FVBNJ_G0017981
protein coding gene Chr11:30743731-30789714 (+)
LP/J MGP_LPJ_G0018059
protein coding gene Chr11:32646511-32691801 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018005
protein coding gene Chr11:35966157-36013090 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018584
protein coding gene Chr11:32275252-32320511 (+)
PWK/PhJ MGP_PWKPhJ_G0017249
protein coding gene Chr11:31106659-31172295 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017041
protein coding gene Chr11:32005988-32073608 (+)
WSB/EiJ MGP_WSBEiJ_G0017517
protein coding gene Chr11:31911914-31957093 (+)



Homology
more
  • Human Ortholog
    LCP2, lymphocyte cytosolic protein 2
  • Vertebrate Orthologs
    11
  • Human Ortholog
    LCP2, lymphocyte cytosolic protein 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    SLP76, SLP-76
  • Links
    NCBI Gene ID: 3937
    neXtProt AC: NX_Q13094
    UniProt: Q13094

  • Chr Location
    5q35.1; chr5:170248084-170297818 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 4065
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: LCP2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    39 phenotypes from 9 alleles in 9 genetic backgrounds
    24 phenotypes from multigenic genotypes
    72 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
T cell development is blocked and T cell receptor signaling impaired in homozygous point mutants. Double positive thymocyte and single positive T cell numbers are much reduced. Both positive and negative thymocyte selection is abnormal. Mice have high IgG and IgE levels and exhibit autoimmunity.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16822 NCBI Gene Model | MGI Sequence Detail 45080 C57BL/6J ±  kb
    transcript NM_010696 RefSeq | MGI Sequence Detail 3622 C57BL/6  
    polypeptide Q60787 UniProt | EBI | MGI Sequence Detail 533 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 38
      cDNA 38

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2144122, MGI:2144608, MGI:3584401, MGI:5491499
    References
    more
    • Summaries
      All 120
      Developmental Gene Expression 2
      Gene Ontology 11
      Phenotypes 72
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:246908 Navas VH, et al., Serine Phosphorylation of SLP76 Is Dispensable for T Cell Development but Modulates Helper T Cell Function. PLoS One. 2017;12(1):e0170396

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory