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Lcp2 Gene Detail
Summary
  • Symbol
    Lcp2
  • Name
    lymphocyte cytosolic protein 2
  • Synonyms
    m1Khoe, SLP76, SLP-76, twm
  • Feature Type
    protein coding gene
  • IDs
    MGI:1321402
    NCBI Gene: 16822
  • Gene Overview
    MyGene.info: LCP2
Location & Maps
more
  • Sequence Map
    Chr11:34046920-34092295 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      45376 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 19.43 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    LCP2, lymphocyte cytosolic protein 2
  • Vertebrate Orthologs
    11
  • Human Ortholog
    LCP2, lymphocyte cytosolic protein 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    SLP76, SLP-76
  • Links
    NCBI Gene ID: 3937
    neXtProt AC: NX_Q13094

  • Chr Location
    5q35.1; chr5:170247754-170297818 (-)  GRCh38.p2
  • HomoloGene
    Vertebrate Homology Class 4065
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: LCP2
  • Gene Tree
    Lcp2
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    39 phenotypes from 9 alleles in 9 genetic backgrounds
    24 phenotypes from multigenic genotypes
    70 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    14
  • Chemically induced (ENU)
    2
  • Chemically induced (other)
    1
  • Targeted
    11
  • Genomic Mutations
    1 involving Lcp2
  • Incidental Mutations
    Mutagenetix , APF
T cell development is blocked and T cell receptor signaling impaired in homozygous point mutants. Double positive thymocyte and single positive T cell numbers are much reduced. Both positive and negative thymocyte selection is abnormal. Mice have high IgG and IgE levels and exhibit autoimmunity.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    12
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    5
  • Tissues
    1
  • cDNA Data
    34
  • Literature Summary
    2
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005404 VEGA Gene Model | MGI Sequence Detail 45376 C57BL/6J ±  kb
transcript OTTMUST00000012047 VEGA | MGI Sequence Detail 3644 Not Applicable  
polypeptide OTTMUSP00000005584 VEGA | MGI Sequence Detail 533 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    140 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 37
    cDNA 37

    Microarray probesets 4
Other
Accession IDs
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MGI:2144122, MGI:2144608, MGI:3584401, MGI:5491499
References
more
  • Summaries
    All 104
    Developmental Gene Expression 2
    Gene Ontology 6
    Phenotypes 70
  • Earliest
    J:24168 Jackman JK, et al., Molecular cloning of SLP-76, a 76-kDa tyrosine phosphoprotein associated with Grb2 in T cells. J Biol Chem. 1995 Mar 31;270(13):7029-32
  • Latest
    J:229762 Lampe K, et al., Slp-76 is a critical determinant of NK-cell mediated recognition of missing-self targets. Eur J Immunol. 2015 Jul;45(7):2072-83
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/13/2016
MGI 6.05 		The Jackson Laboratory