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F11r Gene Detail
Summary
  • Symbol
    F11r
  • Name
    F11 receptor
  • Synonyms
    BV11 antigen, ESTM33, JAM-1, JAM-A, Jcam1, Ly106
  • Feature Type
    protein coding gene
  • IDs
    MGI:1321398
    NCBI Gene: 16456
  • Gene Overview
    MyGene.info: F11R
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:171437561-171464593 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 79.43 cM, cytoband H2
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    298 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1321398
protein coding gene Chr1:171437535-171464603 (.)
129S1/SvImJ MGP_129S1SvImJ_G0016763
protein coding gene Chr1:177240949-177272811 (+)
A/J MGP_AJ_G0016743
protein coding gene Chr1:170014445-170042007 (+)
AKR/J MGP_AKRJ_G0016709
protein coding gene Chr1:175113410-175145524 (+)
BALB/cJ MGP_BALBcJ_G0016704
protein coding gene Chr1:170508672-170536057 (+)
C3H/HeJ MGP_C3HHeJ_G0016527
protein coding gene Chr1:175369739-175407546 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017165
protein coding gene Chr1:183132830-183160951 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014873
protein coding gene Chr1:161703143-161729475 (+)
CAST/EiJ MGP_CASTEiJ_G0016108
protein coding gene Chr1:174991856-175019921 (+)
CBA/J MGP_CBAJ_G0016502
protein coding gene Chr1:189645878-189684561 (+)
DBA/2J MGP_DBA2J_G0016609
protein coding gene Chr1:168856362-168884034 (+)
FVB/NJ MGP_FVBNJ_G0016605
protein coding gene Chr1:167208538-167237915 (+)
LP/J MGP_LPJ_G0016680
protein coding gene Chr1:178350384-178378254 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016632
protein coding gene Chr1:196920195-196948033 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017202
protein coding gene Chr1:174978434-175005363 (+)
PWK/PhJ MGP_PWKPhJ_G0015894
protein coding gene Chr1:168081480-168109810 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015678
protein coding gene Chr1:173771483-173795775 (+)
WSB/EiJ MGP_WSBEiJ_G0016170
protein coding gene Chr1:175100007-175128027 (+)



Homology
more
  • Human Ortholog
    F11R, F11 receptor
  • Vertebrate Orthologs
    9
  • Human Ortholog
    F11R, F11 receptor
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CD321, JAM, JAM1, JAMA, JCAM, KAT, PAM-1
  • Links
    NCBI Gene ID: 50848
    neXtProt AC: NX_Q9Y624
    UniProt: Q9Y624

  • Chr Location
    1q23.3; chr1:160995211-161021343 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 3 alleles in 2 genetic backgrounds
    34 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice display increased dendritic cell migratory ability and contact hypersensitivity.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 16456 NCBI Gene Model | MGI Sequence Detail 27033 C57BL/6J ±  kb
transcript NM_172647 RefSeq | MGI Sequence Detail 2482 C57BL/6  
polypeptide O88792 UniProt | EBI | MGI Sequence Detail 300 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 109
    Genomic 3
    cDNA 101
    Primer pair 5

    Microarray probesets 3
Other
Accession IDs
less
MGI:1334465
References
more
  • Summaries
    All 96
    Developmental Gene Expression 20
    Gene Ontology 9
    Phenotypes 34
  • Earliest
    J:48708 Martin-Padura I, et al., Junctional adhesion molecule, a novel member of the immunoglobulin superfamily that distributes at intercellular junctions and modulates monocyte transmigration. J Cell Biol. 1998 Jul 13;142(1):117-27
  • Latest
    J:238636 Fededa JP, et al., MicroRNA-34/449 controls mitotic spindle orientation during mammalian cortex development. EMBO J. 2016 Nov 15;35(22):2386-2398

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory