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Pstpip1 Gene Detail
Summary
  • Symbol
    Pstpip1
  • Name
    proline-serine-threonine phosphatase-interacting protein 1
  • Synonyms
    CD2BP1, def-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1321396
    NCBI Gene: 19200
  • Gene Overview
    MyGene.info: PSTPIP1
  • Alliance
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:56089962-56128888 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 30.13 cM, cytoband C
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    277 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1321396
protein coding gene Chr9:56078447-56128890 (.)
129S1/SvImJ MGP_129S1SvImJ_G0034847
protein coding gene Chr9:55227352-55269674 (+)
A/J MGP_AJ_G0034828
protein coding gene Chr9:53433438-53473652 (+)
AKR/J MGP_AKRJ_G0034757
protein coding gene Chr9:54673642-54715910 (+)
BALB/cJ MGP_BALBcJ_G0034820
protein coding gene Chr9:53221414-53261620 (+)
C3H/HeJ MGP_C3HHeJ_G0034530
protein coding gene Chr9:55135358-55175889 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035339
protein coding gene Chr9:56780576-56825355 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032250
protein coding gene Chr9:52785977-52825721 (+)
CAST/EiJ MGP_CASTEiJ_G0033851
protein coding gene Chr9:55174622-55213485 (+)
CBA/J MGP_CBAJ_G0034501
protein coding gene Chr9:58732844-58780862 (+)
DBA/2J MGP_DBA2J_G0034660
protein coding gene Chr9:53324567-53364341 (+)
FVB/NJ MGP_FVBNJ_G0034602
protein coding gene Chr9:52528862-52567743 (+)
LP/J MGP_LPJ_G0034743
protein coding gene Chr9:55518590-55557336 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034645
protein coding gene Chr9:60253765-60294344 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035361
protein coding gene Chr9:54679911-54718725 (+)
PWK/PhJ MGP_PWKPhJ_G0033556
protein coding gene Chr9:53327556-53368465 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033390
protein coding gene Chr9:54962582-55001556 (+)
WSB/EiJ MGP_WSBEiJ_G0033964
protein coding gene Chr9:54611481-54652713 (+)



Homology
more
  • Human Ortholog
    PSTPIP1, proline-serine-threonine phosphatase interacting protein 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    PSTPIP1, proline-serine-threonine phosphatase interacting protein 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CD2BP1, CD2BP1L, CD2BP1S, H-PIP, PAPAS, PSTPIP
  • Links
    NCBI Gene ID: 9051
    neXtProt AC: NX_O43586
    UniProt: O43586

  • Chr Location
    15q24.3; chr15:76994680-77037475 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 2 alleles in 2 genetic backgrounds
    15 phenotypes from multigenic genotypes
    2 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit defects in immune cells with T cell hyperresponsive to antigen receptor stimulation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000032322 Ensembl Gene Model | MGI Sequence Detail 38927 C57BL/6J ±  kb
transcript ENSMUST00000059206 Ensembl | MGI Sequence Detail 1863 Not Applicable  
polypeptide ENSMUSP00000055823 Ensembl | MGI Sequence Detail 415 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 25
    cDNA 24
    Other 1

    Microarray probesets 4
References
more
  • Summaries
    All 31
    Developmental Gene Expression 4
    Gene Ontology 8
    Phenotypes 2
  • Earliest
    J:54372 Spencer S, et al., PSTPIP: a tyrosine phosphorylated cleavage furrow-associated protein that is a substrate for a PEST tyrosine phosphatase. J Cell Biol. 1997 Aug 25;138(4):845-60
  • Latest
    J:196002 Wang D, et al., Inflammation in mice ectopically expressing human Pyogenic Arthritis, Pyoderma Gangrenosum, and Acne (PAPA) Syndrome-associated PSTPIP1 A230T mutant proteins. J Biol Chem. 2013 Feb 15;288(7):4594-601

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory