Pstpip1
Gene Detail

Symbol Name ID

Pstpip1 proline-serine-threonine phosphatase-interacting protein 1 MGI:1321396

Synonyms

CD2BP1, def-2

Feature Type

protein coding gene

Genetic Map

Chromosome 9

30.13 cM, cytoband C
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr9:56089962-56128888 bp, + strand From VEGA annotation of GRCm38   38927 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:37867  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 chicken; 1 zebrafish

Gene Tree: Pstpip1

Human homologs

Human Homolog		PSTPIP1, proline-serine-threonine phosphatase interacting protein 1
NCBI Gene ID		9051
neXtProt AC		NX_O43586
Human Synonyms		CD2BP1, CD2BP1L, CD2BP1S, H-PIP, PAPAS, PSTPIP
Human Chr (Location)		15q24-q25.1; chr15:77287465-77329671 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human PSTPIP1

Alleles and phenotypes

All alleles(1) : Targeted(1)
 

Mice homozygous for a knock-out allele exhibit defects in immune cells with T cell hyperresponsive to antigen receptor stimulation.

 

Gene Ontology (GO) classifications

All GO classifications: (14 annotations)

Process	cell adhesion, cytokinesis, ...
Component	actomyosin contractile ring, cell projection, ...
Function	actin binding, catalytic activity, ...

External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (30)    Tissues (14)    Images (8)
Theiler Stages: 10, 18, 23, 25, 28

Assay Type	Results
RNA in situ	6
Northern blot	24

cDNA source data(22)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(24) cDNA(23) Other(1)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000026139 (Evidence)
Ensembl Gene Model	ENSMUSG00000032322 (Evidence)
Entrez Gene	19200 (Evidence)
UniGene	2534
DFCI	TC1582411, TC1698234, TC1706052, TC1751893
DoTS	DT.101309221, DT.110587571, DT.481348
NIA Mouse Gene Index	U010524
Consensus CDS Project	CCDS40645.1
International Mouse Knockout Project Status	Pstpip1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000026139	VEGA Gene Model | MGI Sequence Detail	38927	C57BL/6J
transcript	OTTMUST00000064555	VEGA | MGI Sequence Detail	1863	Not Applicable
polypeptide	OTTMUSP00000032087	VEGA | MGI Sequence Detail	415	Not Applicable

All sequences(39) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(140 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001060	Fps/Fes/Fer/CIP4 homology
InterPro	IPR011254	Prismane-like
InterPro	IPR013315	Spectrin alpha chain, SH3 domain
InterPro	IPR001452	Src homology-3 domain
Protein Ontology	PR:000013408	proline-serine-threonine phosphatase-interacting protein 1

References

(Earliest) J:54372 Spencer S, et al., PSTPIP: a tyrosine phosphorylated cleavage furrow-associated protein that is a substrate for a PEST tyrosine phosphatase. J Cell Biol. 1997 Aug 25;138(4):845-60
(Latest) J:190524 Shalom-Barak T, et al., Placental PPARgamma regulates spatiotemporally diverse genes and a unique metabolic network. Dev Biol. 2012 Dec 1;372(1):143-55
All references(31)