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Pstpip1
Gene Detail
 Symbol
Name
ID
Pstpip1
proline-serine-threonine phosphatase-interacting protein 1
MGI:1321396
Synonyms CD2BP1, def-2
Feature Type protein coding gene
Genetic Map
Chromosome 9
30.13 cM, cytoband C
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr9:56089962-56128888 bp, + strand
From VEGA annotation of GRCm38

  38927 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37867  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Pstpip1

Human
homologs
Human Homolog PSTPIP1, proline-serine-threonine phosphatase interacting protein 1
NCBI Gene ID 9051
neXtProt AC  NX_O43586
Human Synonyms  CD2BP1, CD2BP1L, CD2BP1S, H-PIP, PAPAS, PSTPIP
Human Chr (Location)  15q24-q25.1; chr15:76995124-77037332 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human PSTPIP1
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit defects in immune cells with T cell hyperresponsive to antigen receptor stimulation.
 
Interactions
Pstpip1 interacts with 13 markers (Mir25, Mir30c-1, Mir30c-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process cell adhesion, cytokinesis, ...
Component actomyosin contractile ring, cell projection, ...
Function actin binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (30)    Tissues (14)    Images (8)
Theiler Stages: 10, 18, 23, 25, 28
Assay TypeResults
RNA in situ 6
Northern blot 24
cDNA source data(22)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(24) cDNA(23) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000026139 (Evidence)
Ensembl Gene ModelENSMUSG00000032322 (Evidence)
Entrez Gene19200 (Evidence)
UniGene2534
DFCITC1582411, TC1698234, TC1706052, TC1751893
DoTSDT.101309221, DT.110587571, DT.481348
NIA Mouse Gene IndexU010524
Consensus CDS ProjectCCDS40645.1
International Mouse Knockout Project StatusPstpip1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026139 VEGA Gene Model | MGI Sequence Detail 38927 C57BL/6J ±  kb
transcript OTTMUST00000064555 VEGA | MGI Sequence Detail 1863 Not Applicable 
polypeptide OTTMUSP00000032087 VEGA | MGI Sequence Detail 415 Not Applicable 

For the selected sequences
All sequences(49) RefSeq(12) UniProt(1)
Polymorphisms SNPs within 2kb(280 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001060 FCH domain
InterPro IPR013315 Spectrin alpha chain, SH3 domain
InterPro IPR001452 Src homology-3 domain
Protein Ontology PR:000013408 proline-serine-threonine phosphatase-interacting protein 1
References (Earliest) J:54372 Spencer S, et al., PSTPIP: a tyrosine phosphorylated cleavage furrow-associated protein that is a substrate for a PEST tyrosine phosphatase. J Cell Biol. 1997 Aug 25;138(4):845-60
(Latest) J:196002 Wang D, et al., Inflammation in mice ectopically expressing human Pyogenic Arthritis, Pyoderma Gangrenosum, and Acne (PAPA) Syndrome-associated PSTPIP1 A230T mutant proteins. J Biol Chem. 2013 Feb 15;288(7):4594-601
All references(35)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory