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Gdf2
Gene Detail
Symbol

Name
ID
Gdf2
growth differentiation factor 2
MGI:1321394
Synonyms
Bmp9
Feature Type
protein coding gene
Genetic Map
Chromosome 14
20.80 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr14:33941039-33947198 bp, + strand
From NCBI annotation of GRCm38

  6160 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:32299  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: bone morphogenetic protein
Gene Tree: Gdf2

Human
homologs
Human Homolog GDF2, growth differentiation factor 2
NCBI Gene ID 2658
neXtProt AC  NX_Q9UK05
Human Synonyms  BMP9, BMP-9, HHT5
Human Chr (Location)  10q11.22; chr10:47322490-47327317 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human GDF2
Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit arteriovenous malformations, skeletal abnormalities and abnormal retinal vasculature following anti-BMP10-antibody treatment.
 
Interactions
Gdf2 interacts with 187 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (43 annotations)
Process activin receptor signaling pathway, angiogenesis, ...
Component cell, extracellular region, ...
Function cytokine activity, growth factor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (9 records)
Data Summary: Results (8)    Tissues (6)    Images (4)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 8
cDNA source data(9)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(12) cDNA(9) Primer pair(3)
Microarray probesets(2)
Other database
links
Ensembl Gene ModelENSMUSG00000072625 (Evidence)
Entrez Gene12165 (Evidence)
UniGene422844
DFCITC1590858, TC1595220
DoTSDT.40148047, DT.97409594
Consensus CDS ProjectCCDS26928.1
International Mouse Knockout Project StatusGdf2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 12165 NCBI Gene Model | MGI Sequence Detail 6160 C57BL/6J ±  kb
transcript NM_019506 RefSeq | MGI Sequence Detail 2988 C57BL/6 
polypeptide Q9WV56 UniProt | EBI | MGI Sequence Detail 428 Not Applicable 

For the selected sequences
All sequences(18) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(74 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002405 Inhibin, alpha subunit
InterPro IPR017948 Transforming growth factor beta, conserved site
InterPro IPR001839 Transforming growth factor-beta, C-terminal
InterPro IPR001111 Transforming growth factor-beta, N-terminal
InterPro IPR015615 Transforming growth factor-beta-related
Protein Ontology PR:000007921 growth/differentiation factor 2
Graphical View of Protein Domain Structure
References
(Earliest) J:48647 Celeste AJ, et al., Bone morphogenetic protein-9, a new member of the TGF-beta superfamily. J Bone Miner Res. 1994;Suppl:S136 (Abstr. 64)
(Latest) J:202927 Yoshimatsu Y, et al., Bone morphogenetic protein-9 inhibits lymphatic vessel formation via activin receptor-like kinase 1 during development and cancer progression. Proc Natl Acad Sci U S A. 2013 Nov 19;110(47):18940-5
All references(51)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory