Gdf2
Gene Detail

Symbol Name ID

Gdf2 growth differentiation factor 2 MGI:1321394

Synonyms

Bmp9

Feature Type

protein coding gene

Genetic Map

Chromosome 14

20.80 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr14:33941039-33947198 bp, + strand From NCBI annotation of GRCm38   6160 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:32299  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: bone morphogenetic protein
Gene Tree: Gdf2

Human homologs

Human Homolog		GDF2, growth differentiation factor 2
NCBI Gene ID		2658
neXtProt AC		NX_Q9UK05
Human Synonyms		BMP9, BMP-9
Human Chr (Location)		10q11.22; chr10:48413092-48416853 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(2) : Targeted(2)
 

Mice homozygous for a knock-out allele exhibit arteriovenous malformations, skeletal abnormalities and abnormal retinal vasculature following anti-BMP10-antibody treatment.

 

Gene Ontology (GO) classifications

All GO classifications: (39 annotations)

Process	activin receptor signaling pathway, angiogenesis, ...
Component	extracellular region, extracellular space
Function	cytokine activity, growth factor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (9 records)
Data Summary: Results (8)    Tissues (6)    Images (4)
Theiler Stages: 19, 22, 25

Assay Type	Results
RT-PCR	8

cDNA source data(9)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(12) cDNA(9) Primer pair(3)
Microarray probesets(2)

Other database links

Ensembl Gene Model	ENSMUSG00000072625 (Evidence)
Entrez Gene	12165 (Evidence)
UniGene	422844
DFCI	TC1590858, TC1595220
DoTS	DT.40148047, DT.97409594
Consensus CDS Project	CCDS26928.1
International Mouse Knockout Project Status	Gdf2

Sequences

Length	Strain/Species
genomic	12165	NCBI Gene Model | MGI Sequence Detail	6160	C57BL/6J
transcript	NM_019506	RefSeq | MGI Sequence Detail	2988	C57BL/6
polypeptide	Q9WV56	UniProt | EBI | MGI Sequence Detail	428	Not Applicable

All sequences(18) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(11 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002405	Inhibin, alpha subunit
InterPro	IPR017948	Transforming growth factor beta, conserved site
InterPro	IPR001839	Transforming growth factor-beta, C-terminal
InterPro	IPR001111	Transforming growth factor-beta, N-terminal
InterPro	IPR015615	Transforming growth factor-beta-related
Protein Ontology	PR:000007921	growth/differentiation factor 2

Graphical View of Protein Domain Structure

References

(Earliest) J:48647 Celeste AJ, et al., Bone morphogenetic protein-9, a new member of the TGF-beta superfamily. J Bone Miner Res. 1994;Suppl:S136 (Abstr. 64)
(Latest) J:190018 Tian H, et al., Endoglin mediates fibronectin/alpha5beta1 integrin and TGF-beta pathway crosstalk in endothelial cells. EMBO J. 2012 Oct 3;31(19):3885-900
All references(45)