Timeless
Gene Detail

Symbol Name ID

Timeless timeless circadian clock 1 MGI:1321393

Synonyms

tim

Feature Type

protein coding gene

Genetic Map

Chromosome 10

76.49 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr10:128232065-128252941 bp, + strand From VEGA annotation of GRCm38   20877 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:31206  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Gene Tree: Timeless

Human homologs

Human Homolog		TIMELESS, timeless circadian clock
NCBI Gene ID		8914
neXtProt AC		NX_Q9UNS1
Human Synonyms		hTIM, TIM, TIM1
Human Chr (Location)		12q13.3; chr12:56810157-56843200 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(34) : Targeted(4) Gene trapped(30)
 

Mice homozygous for a targeted mutation exhibit early embryonic lethality at aprroximately the time of implantation.

 

Gene Ontology (GO) classifications

All GO classifications: (26 annotations)

Process	branching involved in ureteric bud morphogenesis, branching morphogenesis of an epithelial tube, ...
Component	nuclear chromatin, nucleus
Function	protein binding, protein heterodimerization activity, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (6 records)
Data Summary: Results (36)    Tissues (30)    Images (10)
Theiler Stages: 10, 11, 15, 18, 19, 22, 23, 25, 28

Assay Type	Results
RNA in situ	21
Northern blot	13
Western blot	2

cDNA source data(113)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(115) cDNA(113) Primer pair(1) Other(1)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000024310 (Evidence)
Ensembl Gene Model	ENSMUSG00000039994 (Evidence)
Entrez Gene	21853 (Evidence)
UniGene	6458
DFCI	TC1575647, TC1681424
DoTS	DT.101149074, DT.110625785, DT.491062, DT.91340849, DT.94215822
Consensus CDS Project	CCDS24266.1, CCDS48724.1, CCDS48725.1
International Mouse Knockout Project Status	Timeless

Sequences

Length	Strain/Species
genomic	OTTMUSG00000024310	VEGA Gene Model | MGI Sequence Detail	20877	C57BL/6J
transcript	OTTMUST00000059534	VEGA | MGI Sequence Detail	4457	Not Applicable
polypeptide	OTTMUSP00000028961	VEGA | MGI Sequence Detail	1197	Not Applicable

All sequences(90) RefSeq(8) UniProt(5)

Polymorphisms

PCR(1) : SNPs(101 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR007725	Timeless C-terminal
InterPro	IPR006906	Timeless protein
Protein Ontology	PR:000016340	protein timeless

References

(Earliest) J:51391 Zylka MJ, et al., Molecular analysis of mammalian timeless. Neuron. 1998 Nov;21(5):1115-22
(Latest) J:171080 O'Reilly LP, et al., An unexpected role for the clock protein timeless in developmental apoptosis. PLoS One. 2011;6(2):e17157
All references(44)

Other accession IDs

MGI:2143916