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Timeless
Gene Detail
 Symbol
Name
ID
Timeless
timeless circadian clock 1
MGI:1321393
Synonyms tim
Feature Type protein coding gene
Genetic Map
Chromosome 10
76.49 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr10:128232065-128252941 bp, + strand
From VEGA annotation of GRCm38

  20877 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:31206  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Gene Tree: Timeless

Human
homologs
Human Homolog TIMELESS, timeless circadian clock
NCBI Gene ID 8914
neXtProt AC  NX_Q9UNS1
Human Synonyms  hTIM, TIM, TIM1
Human Chr (Location)  12q13.3; chr12:56416373-56449416 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(34) : Gene trapped(30) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a targeted mutation exhibit early embryonic lethality at aprroximately the time of implantation.
 
Interactions
Timeless interacts with 88 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (28 annotations)
Process branching involved in ureteric bud morphogenesis, branching morphogenesis of an epithelial tube, ...
Component nuclear chromatin, nucleus
Function protein binding, protein heterodimerization activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (36)    Tissues (30)    Images (10)
Theiler Stages: 10, 11, 15, 18, 19, 22, 23, 25, 28
Assay TypeResults
RNA in situ 21
Northern blot 13
Western blot 2
cDNA source data(107)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(109) cDNA(107) Primer pair(1) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000024310 (Evidence)
Ensembl Gene ModelENSMUSG00000039994 (Evidence)
Entrez Gene21853 (Evidence)
UniGene6458
DFCITC1575647, TC1681424
DoTSDT.101149074, DT.110625785, DT.491062, DT.91340849, DT.94215822
Consensus CDS ProjectCCDS24266.1, CCDS48724.1, CCDS48725.1
International Mouse Knockout Project StatusTimeless
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024310 VEGA Gene Model | MGI Sequence Detail 20877 C57BL/6J ±  kb
transcript OTTMUST00000059534 VEGA | MGI Sequence Detail 4457 Not Applicable 
polypeptide OTTMUSP00000028961 VEGA | MGI Sequence Detail 1197 Not Applicable 

For the selected sequences
All sequences(98) RefSeq(16) UniProt(5)
Polymorphisms PCR(1) : SNPs within 2kb(257 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007725 Timeless C-terminal
InterPro IPR006906 Timeless protein
Protein Ontology PR:000016340 protein timeless
References (Earliest) J:51391 Zylka MJ, et al., Molecular analysis of mammalian timeless. Neuron. 1998 Nov;21(5):1115-22
(Latest) J:209425 Kang TH, et al., Modulation of ATR-mediated DNA damage checkpoint response by cryptochrome 1. Nucleic Acids Res. 2014 Apr;42(7):4427-34
All references(45)
Other
accession IDs
MGI:2143916

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory