Timeless MGI Mouse Gene Detail - MGI:1321393

Symbol

Timeless
Name

timeless circadian clock 1
Synonyms

tim

Feature Type

protein coding gene
IDs

MGI:1321393
NCBI Gene: 21853
Alliance

genome feature page
Transcription Start Sites

12 TSS

Sequence Map

Chr10:128067934-128088810 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 76.49 cM
Mapping Data

2 experiments

SNPs within 2kb

613 from dbSNP Build 142
Strain Annotations

19
PCR

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1321393	protein coding gene	Chr10:128067932-128088810 (+)
129S1/SvImJ	ENSMUSG00200011953	protein coding gene	Chr10:124421966-124442858 (+)
A/J	ENSMUSG00195015650	protein coding gene	Chr10:124885211-124906102 (+)
AKR/J	ENSMUSG00220005081	protein coding gene	Chr10:124490788-124511705 (+)
BALB/cJ	ENSMUSG00180010002	protein coding gene	Chr10:124876178-124897072 (+)
C3H/HeJ	ENSMUSG00175005934	protein coding gene	Chr10:124875572-124896409 (+)
C57BL/6NJ	ENSMUSG00215006653	protein coding gene	Chr10:124486337-124507216 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015925	protein coding gene	Chr10:120593098-120613664 (+)
CAST/EiJ	ENSTCUG00005035206	protein coding gene	Chr10:123873940-123895032 (+)
CBA/J	ENSMUSG00210008855	protein coding gene	Chr10:124699798-124720634 (+)
DBA/2J	ENSMUSG00185024014	protein coding gene	Chr10:124853671-124874545 (+)
FVB/NJ	ENSMUSG00205018604	protein coding gene	Chr10:124095570-124116454 (+)
JF1/MsJ	ENSUMUG00000018984	protein coding gene	Chr10:126163696-126184942 (+)
LP/J	ENSMUSG00230032331	protein coding gene	Chr10:126775868-126796782 (+)
NOD/ShiLtJ	ENSMUSG00190014052	protein coding gene	Chr10:124917327-124938205 (+)
NZO/HlLtJ	ENSMUSG00225036961	protein coding gene	Chr10:130978287-130999130 (+)
PWK/PhJ	ENSLUMG00010008882	protein coding gene	Chr10:124615141-124636399 (+)
SPRET/EiJ	ENSMSPG00010029413	protein coding gene	Chr10:126580062-126600210 (+)
WSB/EiJ	ENSIUOG00005007952	protein coding gene	Chr10:124491679-124512764 (+)

Human Ortholog

TIMELESS, timeless circadian regulator

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TIMELESS, timeless circadian regulator
Synonyms

FASPS4, hTIM, TIM, TIM1
Links

HGNC:11813

NCBI Gene ID: 8914

UniProt: Q9UNS1
Chr Location

12q13.3; chr12:56416363-56449445 (-) GRCh38

MGI Vertebrate Homology

Timeless stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TIMELESS
Gene Tree

Timeless

Diseases

2 with human TIMELESS associations

				Human Disease	Mouse Models
				advanced sleep phase syndrome 4 IDs advanced sleep phase syndrome 4 DOID:0061006 OMIM:620015
				alcohol use disorder IDs alcohol use disorder DOID:1574 ICD10CM:F10.1 ICD9CM:305.0 ICD9CM:305.00 MESH:D000437 NCI:C20701 UMLS_CUI:C0085762

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

2 phenotypes from 2 alleles in 2 genetic backgrounds
17 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

39
Endonuclease-mediated

5
Gene trapped

29
Targeted

5
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

64 strains or lines available

Mice homozygous for a targeted mutation exhibit early embryonic lethality at aprroximately the time of implantation.

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All GO Annotations

73
GO References

17

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

780
Tissues

96
cDNA Data

117
Literature Summary

8

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase timeless

ZFIN timeless

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All Sequences

92
RefSeq

20
UniProt

5
CCDS

CCDS24266.1, CCDS48724.1, CCDS48725.1

Ensembl

ENSMUSG00000039994 (Evidence)
NCBI Gene

21853

			Length	Strain/Species	Flank
genomic	ENSMUSG00000039994	Ensembl Gene Model \| MGI Sequence Detail	20877	C57BL/6J	± kb
transcript	ENSMUST00000055539	Ensembl \| MGI Sequence Detail	4457	Not Applicable
polypeptide	ENSMUSP00000058021	Ensembl \| MGI Sequence Detail	1197	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000016340 protein timeless

(term hierarchy)
InterPro Domains

IPR044998 Timeless

IPR006906 Timeless, N-terminal

IPR007725 Timeless, PAB domain

IPR059212 TIMELESS, tri-helical helix-turn-helix domain

IPR060740 TOF1-like, helical domain
GlyGen

Q9R1X4 1 site, 1 O-linked glycan (1 site)

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All nucleic 126

cDNA 117

Primer pair 3

Other 6

Antibodies 3

Microarray probesets 4

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MGI:2143916

Summaries

All 65

Developmental Gene Expression 8

Gene Ontology 17

Phenotypes 17
Earliest

J:51391 Zylka MJ, et al., Molecular analysis of mammalian timeless. Neuron. 1998 Nov;21(5):1115-22
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Timeless:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr96359	Chr10:128067255-128067266 (+)	-673 bp
Tssr96360	Chr10:128067293-128067304 (+)	-635 bp
Tssr96361	Chr10:128067450-128067463 (+)	-477 bp
Tssr96362	Chr10:128067499-128067510 (+)	-429 bp
Tssr96363	Chr10:128067612-128067623 (+)	-316 bp
Tssr96364	Chr10:128067624-128067639 (+)	-302 bp
Tssr96365	Chr10:128067941-128067963 (+)	18 bp
Tssr96366	Chr10:128067965-128067970 (+)	34 bp
Tssr96367	Chr10:128068179-128068224 (+)	268 bp
Tssr96368	Chr10:128073903-128073938 (+)	5,987 bp
Tssr96369	Chr10:128080697-128080700 (+)	12,765 bp
Tssr96370	Chr10:128083135-128083201 (+)	15,234 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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