About   Help   FAQ
Entpd3 Gene Detail
Summary
  • Symbol
    Entpd3
  • Name
    ectonucleoside triphosphate diphosphohydrolase 3
  • Synonyms
    Cd39l3, HB6, NTPDase-3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1321386
    NCBI Gene: 215446
  • Gene Overview
    MyGene.info: ENTPD3
Location & Maps
more
  • Sequence Map
    Chr9:120539818-120568318 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      28501 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 71.71 cM, cytoband F4
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    ENTPD3, ectonucleoside triphosphate diphosphohydrolase 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ENTPD3, ectonucleoside triphosphate diphosphohydrolase 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CD39L3, HB6, NTPDase-3
  • Links
    NCBI Gene ID: 956
    neXtProt AC: NX_O75355

  • Chr Location
    3p22.1; chr3:40387156-40428626 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    2 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit no deficits in nucleotide hydrolysis or alterations in nociceptive behaviors except for a modest reduction in beta-alanine-mediated itch behavior.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025405 VEGA Gene Model | MGI Sequence Detail 28501 C57BL/6J ±  kb
transcript OTTMUST00000062556 VEGA | MGI Sequence Detail 3444 Not Applicable  
polypeptide OTTMUSP00000030853 VEGA | MGI Sequence Detail 529 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    293 from dbSNP Build 142
Protein
Information
less
  • UniProt
    4 Sequences
  • EC
  • InterPro Domains
    IPR000407 Nucleoside phosphatase GDA1/CD39
Molecular
Reagents
less
  • All nucleic 12
    cDNA 12

    Microarray probesets 4
References
more
  • Summaries
    All 25
    Developmental Gene Expression 3
    Gene Ontology 2
    Phenotypes 2
  • Earliest
    J:48684 Chadwick BP, et al., The CD39-like gene family: identification of three new human members (CD39L2, CD39L3, and CD39L4), their murine homologues, and a member of the gene family from Drosophila melanogaster. Genomics. 1998 Jun 15;50(3):357-67
  • Latest
    J:217933 McCoy E, et al., Deletion of ENTPD3 does not impair nucleotide hydrolysis in primary somatosensory neurons or spinal cord. F1000Research. 2014;3

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/22/2016
MGI 6.06
The Jackson Laboratory