About   Help   FAQ
Entpd3 Gene Detail
Summary
  • Symbol
    Entpd3
  • Name
    ectonucleoside triphosphate diphosphohydrolase 3
  • Synonyms
    Cd39l3, HB6, NTPDase-3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1321386
    NCBI Gene: 215446
  • Gene Overview
    MyGene.info: ENTPD3
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:120539818-120568327 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 71.71 cM, cytoband F4
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    293 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1321386
protein coding gene Chr9:120539818-120568327 (.)
129S1/SvImJ MGP_129S1SvImJ_G0035436
protein coding gene Chr9:123400007-123431982 (+)
A/J MGP_AJ_G0035417
protein coding gene Chr9:118758361-118787622 (+)
AKR/J MGP_AKRJ_G0035350
protein coding gene Chr9:121875702-121907095 (+)
BALB/cJ MGP_BALBcJ_G0035413
protein coding gene Chr9:118657655-118687628 (+)
C3H/HeJ MGP_C3HHeJ_G0035121
protein coding gene Chr9:122353757-122382082 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035936
protein coding gene Chr9:126758015-126792354 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032818
protein coding gene Chr9:115947913-115976489 (+)
CAST/EiJ MGP_CASTEiJ_G0034425
protein coding gene Chr9:122389389-122421179 (+)
CBA/J MGP_CBAJ_G0035088
protein coding gene Chr9:131458177-131488605 (+)
DBA/2J MGP_DBA2J_G0035247
protein coding gene Chr9:118216535-118245068 (+)
FVB/NJ MGP_FVBNJ_G0035194
protein coding gene Chr9:117104129-117133699 (+)
LP/J MGP_LPJ_G0035326
protein coding gene Chr9:123742535-123773971 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035235
protein coding gene Chr9:132423104-132464684 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035955
protein coding gene Chr9:122292660-122326093 (+)
PWK/PhJ MGP_PWKPhJ_G0034130
protein coding gene Chr9:118659619-118688837 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033966
protein coding gene Chr9:122370811-122402618 (+)
WSB/EiJ MGP_WSBEiJ_G0034545
protein coding gene Chr9:122167864-122200528 (+)



Homology
more
  • Human Ortholog
    ENTPD3, ectonucleoside triphosphate diphosphohydrolase 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ENTPD3, ectonucleoside triphosphate diphosphohydrolase 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CD39L3, HB6, NTPDase-3
  • Links
    NCBI Gene ID: 956
    neXtProt AC: NX_O75355
    UniProt: O75355

  • Chr Location
    3p22.1; chr3:40387156-40428626 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    2 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit no deficits in nucleotide hydrolysis or alterations in nociceptive behaviors except for a modest reduction in beta-alanine-mediated itch behavior.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 215446 NCBI Gene Model | MGI Sequence Detail 28510 C57BL/6J ±  kb
transcript NM_178676 RefSeq | MGI Sequence Detail 3467 C57BL/6  
polypeptide NP_848791 RefSeq | MGI Sequence Detail 529 C57BL/6  
For the selected sequence
Protein
Information
less
  • UniProt
    4 Sequences
  • EC
  • InterPro Domains
    IPR000407 Nucleoside phosphatase GDA1/CD39
Molecular
Reagents
less
  • All nucleic 13
    cDNA 13

    Microarray probesets 4
References
more
  • Summaries
    All 27
    Developmental Gene Expression 4
    Gene Ontology 2
    Phenotypes 2
  • Earliest
    J:48684 Chadwick BP, et al., The CD39-like gene family: identification of three new human members (CD39L2, CD39L3, and CD39L4), their murine homologues, and a member of the gene family from Drosophila melanogaster. Genomics. 1998 Jun 15;50(3):357-67
  • Latest
    J:217933 McCoy E, et al., Deletion of ENTPD3 does not impair nucleotide hydrolysis in primary somatosensory neurons or spinal cord. F1000Research. 2014;3

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/06/2018
MGI 6.13
The Jackson Laboratory