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Entpd5 Gene Detail
Summary
  • Symbol
    Entpd5
  • Name
    ectonucleoside triphosphate diphosphohydrolase 5
  • Synonyms
    Cd39l4, ER-UDPase, mNTPase, NTPDase5, NTPDase-5, Pcph
  • Feature Type
    protein coding gene
  • IDs
    MGI:1321385
    NCBI Gene: 12499
  • Gene Overview
    MyGene.info: ENTPD5
  • Alliance
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:84373875-84409029 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 39.18 cM, cytoband E
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    112 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1321385
protein coding gene Chr12:84373857-84409029 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019935
protein coding gene Chr12:85077493-85114455 (-)
A/J MGP_AJ_G0019892
protein coding gene Chr12:81857592-81893009 (-)
AKR/J MGP_AKRJ_G0019868
protein coding gene Chr12:84075701-84110282 (-)
BALB/cJ MGP_BALBcJ_G0019872
protein coding gene Chr12:82191077-82226018 (-)
C3H/HeJ MGP_C3HHeJ_G0019678
protein coding gene Chr12:84538964-84575328 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020323
protein coding gene Chr12:87522876-87570658 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017941
protein coding gene Chr12:78759885-78793725 (-)
CAST/EiJ MGP_CASTEiJ_G0019227
protein coding gene Chr12:79492087-79530861 (-)
CBA/J MGP_CBAJ_G0019649
protein coding gene Chr12:90903884-90946261 (-)
DBA/2J MGP_DBA2J_G0019764
protein coding gene Chr12:81386643-81422003 (-)
FVB/NJ MGP_FVBNJ_G0019750
protein coding gene Chr12:80338123-80373810 (-)
LP/J MGP_LPJ_G0019836
protein coding gene Chr12:84955663-84995453 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019789
protein coding gene Chr12:93818817-93858065 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020357
protein coding gene Chr12:83669564-83704136 (-)
PWK/PhJ MGP_PWKPhJ_G0018991
protein coding gene Chr12:75874335-75911000 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018786
protein coding gene Chr12:78158246-78196755 (-)
WSB/EiJ MGP_WSBEiJ_G0019279
protein coding gene Chr12:84382126-84419347 (-)



Homology
more
  • Human Ortholog
    ENTPD5, ectonucleoside triphosphate diphosphohydrolase 5
  • Vertebrate Orthologs
    11
  • Human Ortholog
    ENTPD5, ectonucleoside triphosphate diphosphohydrolase 5
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CD39L4, NTPDase-5, PCPH
  • Links
    NCBI Gene ID: 957
    neXtProt AC: NX_O75356
    UniProt: O75356

  • Chr Location
    14q24.3; chr14:73959420-74019326 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 37457
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: ENTPD5
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    20 phenotypes from 2 alleles in 2 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele develop progressive hepatopathy, hepatocellular tumors, and spermatogenic arrest.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12499 NCBI Gene Model | MGI Sequence Detail 35155 C57BL/6J ±  kb
    transcript NM_001026214 RefSeq | MGI Sequence Detail 4987 Not Specified  
    polypeptide Q9WUZ9 UniProt | EBI | MGI Sequence Detail 427 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 102
      Genomic 1
      cDNA 100
      Primer pair 1

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGI:2144773, MGI:2144919
    References
    more
    • Summaries
      All 46
      Developmental Gene Expression 8
      Gene Ontology 4
      Phenotypes 9
    • Earliest
      J:45879 Chadwick BP, et al., cDNA cloning and chromosomal mapping of a mouse gene with homology to NTPases. Mamm Genome. 1998 Feb;9(2):162-4
    • Latest
      J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory