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Ppp2ca
Gene Detail
 Symbol
Name
ID
Ppp2ca
protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform
MGI:1321159
Synonyms PP2A
Feature Type protein coding gene
Genetic Map
Chromosome 11
31.86 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr11:52098681-52127778 bp, + strand
From VEGA annotation of GRCm38

  29098 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37660  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: serine/threonine-protein phosphatase, conventional type
Gene Tree: Ppp2ca

Human
homologs
Human Homolog PPP2CA, protein phosphatase 2, catalytic subunit, alpha isozyme
NCBI Gene ID 5515
neXtProt AC  NX_P67775
Human Synonyms  PP2Ac, PP2CA, PP2Calpha, RP-C
Human Chr (Location)  5q31.1; chr5:134196457-134226259 (-)  GRCh38
Alleles
and
phenotypes
All alleles(21) : Targeted(5) Gene trapped(16)
 
Homozygous null embryos die before gastrulation and exhibit widespread degeneration. Mesoderm is not formed.
 
Gene Ontology
(GO)
classifications
All GO classifications: (40 annotations)
Process meiotic nuclear division, mesoderm development, ...
Component chromosome, chromosome, centromeric region, ...
Function GABA receptor binding, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (13 records)
Data Summary: Results (147)    Tissues (122)    Images (16)
Theiler Stages: 17, 21, 22, 23, 28
Assay TypeResults
RNA in situ 118
Western blot 21
RT-PCR 8
cDNA source data(9)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(13) Genomic(2) cDNA(9) Primer pair(2)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000005619 (Evidence)
Ensembl Gene ModelENSMUSG00000020349 (Evidence)
Entrez Gene19052 (Evidence)
DFCITC1573510, TC1620922
NIA Mouse Gene IndexU012578
EC3.1.3.16
Consensus CDS ProjectCCDS24666.1
International Mouse Knockout Project StatusPpp2ca
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005619 VEGA Gene Model | MGI Sequence Detail 29098 C57BL/6J ±  kb
transcript OTTMUST00000012505 VEGA | MGI Sequence Detail 7102 Not Applicable 
polypeptide OTTMUSP00000005798 VEGA | MGI Sequence Detail 309 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(2) UniProt(1)
Polymorphisms SNPs within 2kb(37 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004843 Metallophosphoesterase domain
InterPro IPR006186 Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase
Protein Ontology PR:000003211 serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
References (Earliest) J:50519 Gotz J, et al., Delayed embryonic lethality in mice lacking protein phosphatase 2A catalytic subunit Calpha. Proc Natl Acad Sci U S A. 1998 Oct 13;95(21):12370-5
(Latest) J:201873 MacKay KB, et al., Circumventing embryonic lethality with Lcmt1 deficiency: generation of hypomorphic Lcmt1 mice with reduced protein phosphatase 2A methyltransferase expression and defects in insulin signaling. PLoS One. 2013;8(6):e65967
All references(79)
Other
accession IDs
MGI:2144711

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory