Ppp2ca
Gene Detail

Symbol Name ID

Ppp2ca protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform MGI:1321159

Synonyms

PP2A

Feature Type

protein coding gene

Genetic Map

Chromosome 11

31.86 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr11:52098681-52127778 bp, + strand From VEGA annotation of GRCm38   29098 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:37660  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: serine/threonine-protein phosphatase, conventional type
Gene Tree: Ppp2ca

Human homologs

Human Homolog		PPP2CA, protein phosphatase 2, catalytic subunit, alpha isozyme
NCBI Gene ID		5515
neXtProt AC		NX_P67775
Human Synonyms		PP2Ac, PP2CA, PP2Calpha, RP-C
Human Chr (Location)		5q31.1; chr5:133532148-133561950 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(21) : Targeted(5) Gene trapped(16)
 

Homozygous null embryos die before gastrulation and exhibit widespread degeneration. Mesoderm is not formed.

 

Gene Ontology (GO) classifications

All GO classifications: (35 annotations)

Process	meiosis, mesoderm development, ...
Component	chromosome, chromosome, centromeric region, ...
Function	hydrolase activity, metal ion binding, ...

External Resources: FuncBase

Expression

Literature Summary: (13 records)
Data Summary: Results (147)    Tissues (122)    Images (16)
Theiler Stages: 17, 21, 22, 23, 28

Assay Type	Results
RNA in situ	118
Western blot	21
RT-PCR	8

cDNA source data(9)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(13) Genomic(2) cDNA(9) Primer pair(2)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000005619 (Evidence)
Ensembl Gene Model	ENSMUSG00000020349 (Evidence)
Entrez Gene	19052 (Evidence)
DFCI	TC1573510, TC1620922
NIA Mouse Gene Index	U012578
EC	3.1.3.16
Consensus CDS Project	CCDS24666.1
International Mouse Knockout Project Status	Ppp2ca

Sequences

Length	Strain/Species
genomic	OTTMUSG00000005619	VEGA Gene Model | MGI Sequence Detail	29098	C57BL/6J
transcript	OTTMUST00000012505	VEGA | MGI Sequence Detail	7102	Not Applicable
polypeptide	OTTMUSP00000005798	VEGA | MGI Sequence Detail	309	Not Applicable

All sequences(30) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(30 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR004843	Metallophosphoesterase domain
InterPro	IPR006186	Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase
Protein Ontology	PR:000003211	serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

References

(Earliest) J:50519 Gotz J, et al., Delayed embryonic lethality in mice lacking protein phosphatase 2A catalytic subunit Calpha. Proc Natl Acad Sci U S A. 1998 Oct 13;95(21):12370-5
(Latest) J:193136 Okamura H, et al., Protein phosphatase 2A Calpha is involved in osteoclastogenesis by regulating RANKL and OPG expression in osteoblasts. FEBS Lett. 2013 Jan 4;587(1):48-53
All references(74)

Other accession IDs

MGI:2144711