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Ppp2ca Gene Detail
Summary
  • Symbol
    Ppp2ca
  • Name
    protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform
  • Synonyms
    PP2A
  • Feature Type
    protein coding gene
  • IDs
    MGI:1321159
    NCBI Gene: 19052
  • Gene Overview
    MyGene.info: PPP2CA
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:52098824-52122749 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 31.86 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    33 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1321159
protein coding gene Chr11:52098681-52127778 (.)
129S1/SvImJ MGP_129S1SvImJ_G0018281
protein coding gene Chr11:51396460-51425107 (+)
A/J MGP_AJ_G0018250
protein coding gene Chr11:49439729-49469883 (+)
AKR/J MGP_AKRJ_G0018220
protein coding gene Chr11:51003336-51035705 (+)
BALB/cJ MGP_BALBcJ_G0018221
protein coding gene Chr11:49739604-49768552 (+)
C3H/HeJ MGP_C3HHeJ_G0018032
protein coding gene Chr11:51034546-51064643 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018671
protein coding gene Chr11:52929213-52959924 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016323
protein coding gene Chr11:46990678-47020636 (+)
CAST/EiJ MGP_CASTEiJ_G0017597
protein coding gene Chr11:51038618-51072916 (+)
CBA/J MGP_CBAJ_G0018007
protein coding gene Chr11:55429336-55458239 (+)
DBA/2J MGP_DBA2J_G0018114
protein coding gene Chr11:49146026-49177323 (+)
FVB/NJ MGP_FVBNJ_G0018109
protein coding gene Chr11:48868193-48896815 (+)
LP/J MGP_LPJ_G0018190
protein coding gene Chr11:51803777-51833462 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018132
protein coding gene Chr11:56811125-56840703 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018714
protein coding gene Chr11:51100318-51130123 (+)
PWK/PhJ MGP_PWKPhJ_G0017372
protein coding gene Chr11:49675082-49706665 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017167
protein coding gene Chr11:50833115-50866729 (+)
WSB/EiJ MGP_WSBEiJ_G0017644
protein coding gene Chr11:50745022-50775675 (+)



Homology
more
  • Human Ortholog
    PPP2CA, protein phosphatase 2 catalytic subunit alpha
  • Vertebrate Orthologs
    9
  • Human Ortholog
    PPP2CA, protein phosphatase 2 catalytic subunit alpha
    Orthology source: HomoloGene, HGNC
  • Synonyms
    PP2Ac, PP2CA, PP2Calpha, RP-C
  • Links
    NCBI Gene ID: 5515
    neXtProt AC: NX_P67775
    UniProt: P67775

  • Chr Location
    5q31.1; chr5:134196457-134226259 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    36 phenotypes from 6 alleles in 6 genetic backgrounds
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null embryos die before gastrulation and exhibit widespread degeneration. Mesoderm is not formed.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic 19052 NCBI Gene Model | MGI Sequence Detail 23926 C57BL/6J ±  kb
    transcript NM_019411 RefSeq | MGI Sequence Detail 1930 C57BL/6  
    polypeptide P63330 UniProt | EBI | MGI Sequence Detail 309 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000003211 serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
    • EC
    • InterPro Domains
      IPR004843 Calcineurin-like phosphoesterase domain, ApaH type
      IPR029052 Metallo-dependent phosphatase-like
      IPR006186 Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase
    Molecular
    Reagents
    less
    • All nucleic 14
      Genomic 2
      cDNA 10
      Primer pair 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2144711
    References
    more
    • Summaries
      All 124
      Developmental Gene Expression 16
      Gene Ontology 22
      Phenotypes 19
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:264469 Lee JA, et al., Global loss of leucine carboxyl methyltransferase-1 causes severe defects in fetal liver hematopoiesis. J Biol Chem. 2018 Jun 22;293(25):9636-9650

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory