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Ptprt Gene Detail
Summary
  • Symbol
    Ptprt
  • Name
    protein tyrosine phosphatase, receptor type, T
  • Synonyms
    RPTPrho
  • Feature Type
    protein coding gene
  • IDs
    MGI:1321152
    NCBI Gene: 19281
  • Gene Overview
    MyGene.info: PTPRT
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:161521990-162661147 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 81.91 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    11039 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1321152
protein coding gene Chr2:161521988-162661147 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026811
protein coding gene Chr2:166752501-167928962 (-)
A/J MGP_AJ_G0026777
protein coding gene Chr2:160061346-161178416 (-)
AKR/J MGP_AKRJ_G0026748
protein coding gene Chr2:164799044-165935175 (-)
BALB/cJ MGP_BALBcJ_G0026786
protein coding gene Chr2:160386229-161509801 (-)
C3H/HeJ MGP_C3HHeJ_G0026528
protein coding gene Chr2:165130902-166297379 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027235
protein coding gene Chr2:171684962-172873501 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024605
protein coding gene Chr2:153410718-154494554 (-)
CAST/EiJ MGP_CASTEiJ_G0025990
protein coding gene Chr2:165504163-166659473 (-)
CBA/J MGP_CBAJ_G0026505
protein coding gene Chr2:177883341-179107853 (-)
DBA/2J MGP_DBA2J_G0026643
protein coding gene Chr2:159234398-160366399 (-)
FVB/NJ MGP_FVBNJ_G0026610
protein coding gene Chr2:157624836-158735707 (-)
LP/J MGP_LPJ_G0026746
protein coding gene Chr2:166862775-168059651 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026631
protein coding gene Chr2:181587214-182808674 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027291
protein coding gene Chr2:164643673-165808720 (-)
PWK/PhJ MGP_PWKPhJ_G0025724
protein coding gene Chr2:158788380-159900774 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025527
protein coding gene Chr2:163526491-164682241 (-)
WSB/EiJ MGP_WSBEiJ_G0026060
protein coding gene Chr2:165521908-166686682 (-)



Homology
more
  • Human Ortholog
    PTPRT, protein tyrosine phosphatase, receptor type T
  • Vertebrate Orthologs
    8
  • Human Ortholog
    PTPRT, protein tyrosine phosphatase, receptor type T
    Orthology source: HGNC, HomoloGene
  • Synonyms
    RPTPrho
  • Links
    NCBI Gene ID: 11122
    neXtProt AC: NX_O14522
    UniProt: O14522

  • Chr Location
    20q12-q13.11; chr20:42072752-43189917 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele are highly susceptible to carcinogen azoxymethane-induced colon tumors.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000053141 Ensembl Gene Model | MGI Sequence Detail 1139158 C57BL/6J ±  kb
    transcript ENSMUST00000109441 Ensembl | MGI Sequence Detail 6623 Not Applicable  
    polypeptide ENSMUSP00000105067 Ensembl | MGI Sequence Detail 1455 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 12
      cDNA 10
      Primer pair 1
      Other 1

      Microarray probesets 5
    References
    more
    • Summaries
      All 37
      Developmental Gene Expression 9
      Gene Ontology 4
      Phenotypes 6
    • Earliest
      J:39565 McAndrew PE, et al., Identification and characterization of RPTPrho, a novel RPTPmu/kappa like receptor protein tyrosine phosphatase whose expression is restricted to the central nervous system. Brain Res Mol Brain Res. 1998 May;56(1-2):9-21
    • Latest
      J:229257 Gu Z, et al., Expression of the immunoglobulin superfamily cell adhesion molecules in the developing spinal cord and dorsal root ganglion. PLoS One. 2015;10(3):e0121550

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory