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Gene Detail
protein tyrosine phosphatase, receptor type, T
Synonyms RPTPrho
Feature Type protein coding gene
Genetic Map
Chromosome 2
81.91 cM
Detailed Genetic Map ± 1 cM

Mapping data(3)
Sequence Map
Chr2:161521990-162661147 bp, - strand
From VEGA annotation of GRCm38

  1139158 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
HomoloGene:56924  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

Protein SuperFamily: receptor tyrosine-protein phosphatase, kappa/mu/T/U types
Gene Tree: Ptprt

Human Homolog PTPRT, protein tyrosine phosphatase, receptor type, T
NCBI Gene ID 11122
neXtProt AC  NX_O14522
Human Synonyms  RPTPrho
Human Chr (Location)  20q12-q13; chr20:42072752-43189917 (-)  GRCh38
alleles, and
All mutations/alleles(6) : Gene trapped(2) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
Mice homozygous for a knock-out allele are highly susceptible to carcinogen azoxymethane-induced colon tumors.
Ptprt interacts with 536 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
All GO classifications: (29 annotations)
Process dephosphorylation, homophilic cell adhesion, ...
Component cell surface, integral component of membrane, ...
Function alpha-actinin binding, alpha-catenin binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Literature Summary: (8 records)
Data Summary: Results (204)    Tissues (134)    Images (19)
Theiler Stages: 22, 23, 26, 28
Assay TypeResults
RNA in situ 204
cDNA source data(7)
External Resources: Allen Institute   GEO   Expression Atlas
All nucleic(9) cDNA(8) Primer pair(1)
Microarray probesets(5)
Other database
VEGA Gene ModelOTTMUSG00000015291 (Evidence)
Ensembl Gene ModelENSMUSG00000053141 (Evidence)
Entrez Gene19281 (Evidence)
DFCITC1584979, TC1595766, TC1597337, TC1602290, TC1630505, TC1653786
DoTSDT.101356293, DT.101367609, DT.101732169, DT.40146866, DT.55272125, DT.91339323, DT.91339324, DT.94179697, DT.94179698
NIA Mouse Gene IndexU023609
Consensus CDS ProjectCCDS17001.1, CCDS71182.1, CCDS71183.1
International Mouse Knockout Project StatusPtprt
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015291 VEGA Gene Model | MGI Sequence Detail 1139158 C57BL/6J ±  kb
transcript OTTMUST00000036252 VEGA | MGI Sequence Detail 6623 Not Applicable 
polypeptide OTTMUSP00000016284 VEGA | MGI Sequence Detail 1455 Not Applicable 

For the selected sequences
All sequences(96) RefSeq(36) UniProt(3)
Polymorphisms RFLP(1) : SNPs within 2kb(11172 from dbSNP Build 137)    SNPs within 2kb including multiple locations(11176)
InterPro IPR008985 Concanavalin A-like lectin/glucanases superfamily
InterPro IPR003961 Fibronectin, type III
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003599 Immunoglobulin subtype
InterPro IPR000998 MAM domain
InterPro IPR000387 Protein-tyrosine/Dual specificity phosphatase
InterPro IPR016130 Protein-tyrosine phosphatase, active site
InterPro IPR000242 Protein-tyrosine phosphatase, receptor/non-receptor type
Protein Ontology PR:000013480 receptor-type tyrosine-protein phosphatase T
References (Earliest) J:39565 McAndrew PE, et al., Identification and characterization of RPTPrho, a novel RPTPmu/kappa like receptor protein tyrosine phosphatase whose expression is restricted to the central nervous system. Brain Res Mol Brain Res. 1998 May;56(1-2):9-21
(Latest) J:205051 Miller JA, et al., Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates. Development. 2013 Nov;140(22):4633-44
All references(39)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 5.19
The Jackson Laboratory