About   Help   FAQ
Ptprt
Gene Detail
Symbol

Name
ID
Ptprt
protein tyrosine phosphatase, receptor type, T
MGI:1321152
Synonyms
RPTPrho
Feature Type
protein coding gene
Genetic Map
Chromosome 2
81.91 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr2:161521990-162661147 bp, - strand
From VEGA annotation of GRCm38

  1139158 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:56924  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: PTPRT
Protein SuperFamily: receptor tyrosine-protein phosphatase, kappa/mu/T/U types
Gene Tree: Ptprt

Human
homologs
PTPRT, protein tyrosine phosphatase, receptor type, T
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 11122
neXtProt AC: NX_O14522

Human Synonyms: RPTPrho

Human Chr (Location): 20q12-q13; chr20:42072752-43189917 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(2) Targeted(4)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a knock-out allele are highly susceptible to carcinogen azoxymethane-induced colon tumors.
 
Interactions
Ptprt interacts with 535 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (8 records)
Data Summary: Results (204)    Tissues (134)    Images (19)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 204
cDNA source data(8)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA PTPRT ZFIN ptprt    NEW 
Molecular
reagents
All nucleic(10) cDNA(9) Primer pair(1)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000015291 (Evidence)
Ensembl Gene Model ENSMUSG00000053141 (Evidence)
Entrez Gene 19281 (Evidence)
DFCI TC1630505, TC1653786, TC1597337, TC1602290, TC1584979, TC1595766
DoTS DT.101367609, DT.101356293, DT.91339323, DT.101732169, DT.55272125, DT.40146866, DT.91339324, DT.94179697, DT.94179698
NIA Mouse Gene Index U023609
EC 3.1.3.48
Consensus CDS Project CCDS17001.1, CCDS71182.1, CCDS71183.1
International Mouse Phenotyping Consortium Status Ptprt
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015291 VEGA Gene Model | MGI Sequence Detail 1139158 C57BL/6J ±  kb
transcript OTTMUST00000036252 VEGA | MGI Sequence Detail 6623 Not Applicable 
polypeptide OTTMUSP00000016284 VEGA | MGI Sequence Detail 1455 Not Applicable 

For the selected sequences
All sequences(103) RefSeq(42) UniProt(3)
Polymorphisms
RFLP(1) : SNPs within 2kb(11172 from dbSNP Build 137)    SNPs within 2kb including multiple locations(11176)
Protein-related
information
ResourceIDDescription
InterPro IPR013320 Concanavalin A-like lectin/glucanase, subgroup
InterPro IPR003961 Fibronectin, type III
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003599 Immunoglobulin subtype
InterPro IPR000998 MAM domain
InterPro IPR000387 Protein-tyrosine/Dual specificity phosphatase
InterPro IPR016130 Protein-tyrosine phosphatase, active site
InterPro IPR000242 Protein-tyrosine phosphatase, receptor/non-receptor type
Protein Ontology PR:000013480 receptor-type tyrosine-protein phosphatase T
References
(Earliest) J:39565 McAndrew PE, et al., Identification and characterization of RPTPrho, a novel RPTPmu/kappa like receptor protein tyrosine phosphatase whose expression is restricted to the central nervous system. Brain Res Mol Brain Res. 1998 May;56(1-2):9-21
(Latest) J:205051 Miller JA, et al., Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates. Development. 2013 Nov;140(22):4633-44
All references(37)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/28/2015
MGI 5.22
The Jackson Laboratory