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Hint1
Gene Detail
Symbol

Name
ID
Hint1
histidine triad nucleotide binding protein 1
MGI:1321133
Synonyms
Ipk1, PKCI-1, PKC inhibitor/ interacting protein, PRKCNH1, protein kinase C inhibitor 1
Feature Type
protein coding gene
Genetic Map
Chromosome 11
32.13 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr11:54866383-54870501 bp, + strand
From VEGA annotation of GRCm38

  4119 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3904  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Hint1

Human
homologs
Human Homolog HINT1, histidine triad nucleotide binding protein 1
NCBI Gene ID 3094
neXtProt AC  NX_P49773
Human Synonyms  HINT, NMAN, PKCI-1, PRKCNH1
Human Chr (Location)  5q31.2; chr5:131159283-131165348 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human HINT1
Mutations,
alleles, and
phenotypes
All mutations/alleles(83) : Gene trapped(77) Targeted(6)
 
Homozygous mutant animals do not exhibit an overt phenotype, though one line of mutant mice was shown to be more susceptible to carcinogen-induced tumors than wild-type.
 
Interactions
Hint1 interacts with 33 markers (Mir7-2, Mir7b, Mir22, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (3 records)
Data Summary: Results (21)    Tissues (14)    Tissue x Stage Matrix (view)
Assay TypeResults
Northern blot 10
Western blot 11
cDNA source data(149)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(150) cDNA(150)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000005678 (Evidence)
Ensembl Gene ModelENSMUSG00000020267 (Evidence)
Entrez Gene15254 (Evidence)
UniGene425
DFCITC1572322
DoTSDT.103587961, DT.103600221
NIA Mouse Gene IndexU012620
EC3.-.-.-
Consensus CDS ProjectCCDS24702.1
International Mouse Knockout Project StatusHint1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005678 VEGA Gene Model | MGI Sequence Detail 4119 C57BL/6J ±  kb
transcript OTTMUST00000012643 VEGA | MGI Sequence Detail 636 Not Applicable 
polypeptide OTTMUSP00000005856 VEGA | MGI Sequence Detail 126 Not Applicable 

For the selected sequences
All sequences(28) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(36 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR019808 Histidine triad, conserved site
InterPro IPR001310 Histidine triad (HIT) protein
InterPro IPR011146 HIT-like domain
Protein Ontology PR:000008561 histidine triad nucleotide-binding protein 1
References
(Earliest) J:50522 Klein MG, et al., Characterization of PKCI and comparative studies with FHIT, related members of the HIT protein family. Exp Cell Res. 1998 Oct 10;244(1):26-32
(Latest) J:201686 Jackson KJ, et al., The histidine triad nucleotide binding 1 protein is involved in nicotine reward and physical nicotine withdrawal in mice. Neurosci Lett. 2013 Aug 29;550:129-33
All references(48)
Other
accession IDs
MGI:2144040

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory