Hint1
Gene Detail

Symbol Name ID

Hint1 histidine triad nucleotide binding protein 1 MGI:1321133

Synonyms

Ipk1, PKCI-1, PKC inhibitor/ interacting protein, PRKCNH1, protein kinase C inhibitor 1

Feature Type

protein coding gene

Genetic Map

Chromosome 11

32.13 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr11:54866383-54870501 bp, + strand From VEGA annotation of GRCm38   4119 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:3904  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Hint1

Human homologs

Human Homolog		HINT1, histidine triad nucleotide binding protein 1
NCBI Gene ID		3094
neXtProt AC		NX_P49773
Human Synonyms		HINT, NMAN, PKCI-1, PRKCNH1
Human Chr (Location)		5q31.2; chr5:130494875-130501034 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human HINT1

Alleles and phenotypes

All alleles(83) : Targeted(6) Gene trapped(77)
 

Homozygous mutant animals do not exhibit an overt phenotype, though one line of mutant mice was shown to be more susceptible to carcinogen-induced tumors than wild-type.

 

Gene Ontology (GO) classifications

All GO classifications: (10 annotations)

Process	intrinsic apoptotic signaling pathway by p53 class mediator, purine ribonucleotide catabolic process, ...
Component	cytoplasm, histone deacetylase complex, ...
Function	catalytic activity, hydrolase activity

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (21)    Tissues (14)   
Theiler Stages: 28

Assay Type	Results
Northern blot	10
Western blot	11

cDNA source data(9)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(10) cDNA(10)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000005678 (Evidence)
Ensembl Gene Model	ENSMUSG00000020267 (Evidence)
Entrez Gene	15254 (Evidence)
DFCI	TC1572322
DoTS	DT.103587961, DT.103600221
NIA Mouse Gene Index	U012620
EC	3.-.-.-
Consensus CDS Project	CCDS24702.1
International Mouse Knockout Project Status	Hint1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000005678	VEGA Gene Model | MGI Sequence Detail	4119	C57BL/6J
transcript	OTTMUST00000012643	VEGA | MGI Sequence Detail	636	Not Applicable
polypeptide	OTTMUSP00000005856	VEGA | MGI Sequence Detail	126	Not Applicable

All sequences(29) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(9 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR019808	Histidine triad, conserved site
InterPro	IPR001310	Histidine triad (HIT) protein
InterPro	IPR011146	HIT-like domain
Protein Ontology	PR:000008561	histidine triad nucleotide-binding protein 1

References

(Earliest) J:50522 Klein MG, et al., Characterization of PKCI and comparative studies with FHIT, related members of the HIT protein family. Exp Cell Res. 1998 Oct 10;244(1):26-32
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(42)

Other accession IDs

MGI:2144040