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Aurkc
Gene Detail
 Symbol
Name
ID
Aurkc
aurora kinase C
MGI:1321119
Synonyms AIE1, AIK3, IAK3, Stk13
Feature Type protein coding gene
Genetic Map
Chromosome 7
4.06 cM, cytoband A2-A3
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr7:6995443-7002945 bp, + strand
From Ensembl annotation of GRCm38

  7503 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68302  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: kinase-related transforming protein
Gene Tree: Aurkc

Human
homologs
Human Homolog AURKC, aurora kinase C
NCBI Gene ID 6795
neXtProt AC  NX_Q9UQB9
Human Synonyms  AIE2, AIK3, ARK3, AurC, aurora-C, SPGF5, STK13
Human Chr (Location)  19q13.43; chr19:57230381-57235548 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human AURKC
Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Gene trapped(1) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Male mice homozygous for a knock-out allele are viable but subfertile, as shown by reduced litter sizes or failure to produce a litter. Observed sperm abnormalities include heterogeneous chromatin condensation, loose acrosomes, and blunted heads.
 
Interactions
Aurkc interacts with 2 markers (Mir217, Mir499)
Gene Ontology
(GO)
classifications
All GO classifications: (23 annotations)
Process cell cycle, cell division, ...
Component chromosome, chromosome, centromeric region, ...
Function ATP binding, kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (27)    Tissues (17)    Images (7)
Theiler Stages: 13, 19, 20, 21, 22, 23, 28
Assay TypeResults
RNA in situ 8
Northern blot 17
RT-PCR 2
cDNA source data(10)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(13) Genomic(2) cDNA(10) Primer pair(1)
Microarray probesets(6)
Other database
links
Ensembl Gene ModelENSMUSG00000070837 (Evidence)
Entrez Gene20871 (Evidence)
UniGene261572
DoTSDT.103584149, DT.40148768, DT.40149794, DT.94233532, DT.94233533
EC2.7.11.1
Consensus CDS ProjectCCDS39754.1
International Mouse Knockout Project StatusAurkc
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000070837 Ensembl Gene Model | MGI Sequence Detail 7503 C57BL/6J ±  kb
transcript ENSMUST00000086248 Ensembl | MGI Sequence Detail 948 Not Applicable 
polypeptide ENSMUSP00000083426 Ensembl | MGI Sequence Detail 315 Not Applicable 

For the selected sequences
All sequences(37) RefSeq(16) UniProt(4)
Polymorphisms RFLP(1) : SNPs within 2kb(110 from dbSNP Build 137)    SNPs within 2kb including multiple locations(114)
Protein-related
information
ResourceIDDescription
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000004518 aurora kinase C
References (Earliest) J:50717 Tseng TC, et al., Protein kinase profile of sperm and eggs: cloning and characterization of two novel testis-specific protein kinases (AIE1, AIE2) related to yeast and fly chromosome segregation regulators. DNA Cell Biol. 1998 Oct;17(10):823-33
(Latest) J:211004 Balboula AZ, et al., Selective disruption of aurora C kinase reveals distinct functions from aurora B kinase during meiosis in mouse oocytes. PLoS Genet. 2014 Feb;10(2):e1004194
All references(36)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory