About   Help   FAQ
Aurkc
Gene Detail
Symbol

Name
ID
Aurkc
aurora kinase C
MGI:1321119
Synonyms
AIE1, AIK3, IAK3, Stk13
Feature Type
protein coding gene
Genetic Map
Chromosome 7
4.06 cM, cytoband A2-A3
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr7:6995443-7002945 bp, + strand
From Ensembl annotation of GRCm38

  7503 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68302  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: AURKC
Protein SuperFamily: kinase-related transforming protein
Gene Tree: Aurkc

Human
homologs
AURKC, aurora kinase C
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 6795
neXtProt AC: NX_Q9UQB9

Human Synonyms: AIE2, AIK3, ARK3, AurC, aurora-C, HEL-S-90, SPGF5, STK13

Human Chr (Location): 19q13.43; chr19:57230360-57235550 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human AURKC

Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Gene trapped(1) Targeted(1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Male mice homozygous for a knock-out allele are viable but subfertile, as shown by reduced litter sizes or failure to produce a litter. Observed sperm abnormalities include heterogeneous chromatin condensation, loose acrosomes, and blunted heads.
 
Interactions
Aurkc interacts with 2 markers (Mir217, Mir499)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (4 records)
Data Summary: Results (27)    Tissues (17)    Images (7)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 8
Northern blot 17
RT-PCR 2
cDNA source data(10)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(13) Genomic(2) cDNA(10) Primer pair(1)
Microarray probesets(6)
Other database
links
Ensembl Gene Model ENSMUSG00000070837 (Evidence)
Entrez Gene 20871 (Evidence)
UniGene 261572
DoTS DT.103584149, DT.40148768, DT.40149794, DT.94233532, DT.94233533
Consensus CDS Project CCDS39754.1
International Mouse Phenotyping Consortium Status Aurkc
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000070837 Ensembl Gene Model | MGI Sequence Detail 7503 C57BL/6J ±  kb
transcript ENSMUST00000086248 Ensembl | MGI Sequence Detail 948 Not Applicable 
polypeptide ENSMUSP00000083426 Ensembl | MGI Sequence Detail 315 Not Applicable 

For the selected sequences
All sequences(31) RefSeq(14)
Polymorphisms
RFLP(1) : SNPs within 2kb(110 from dbSNP Build 137)    SNPs within 2kb including multiple locations(114)
Protein-related
information
ResourceIDDescription
Protein Ontology PR:000004518 aurora kinase C
References
(Earliest) J:50717 Tseng TC, et al., Protein kinase profile of sperm and eggs: cloning and characterization of two novel testis-specific protein kinases (AIE1, AIE2) related to yeast and fly chromosome segregation regulators. DNA Cell Biol. 1998 Oct;17(10):823-33
(Latest) J:211004 Balboula AZ, et al., Selective disruption of aurora C kinase reveals distinct functions from aurora B kinase during meiosis in mouse oocytes. PLoS Genet. 2014 Feb;10(2):e1004194
All references(32)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/18/2015
MGI 6.0
The Jackson Laboratory