Aurkc
Gene Detail

Symbol Name ID

Aurkc aurora kinase C MGI:1321119

Synonyms

AIE1, AIK3, IAK3, Stk13

Feature Type

protein coding gene

Genetic Map

Chromosome 7

4.06 cM, cytoband A2-A3
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr7:6995443-7002945 bp, + strand From Ensembl annotation of GRCm38   7503 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:68302  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle

Protein SuperFamily: kinase-related transforming protein
Gene Tree: Aurkc

Human homologs

Human Homolog		AURKC, aurora kinase C
NCBI Gene ID		6795
neXtProt AC		NX_Q9UQB9
Human Synonyms		AIE2, AIK3, ARK3, AurC, aurora-C, SPGF5, STK13
Human Chr (Location)		19q13.43; chr19:57742377-57746916 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human AURKC

Alleles and phenotypes

All alleles(2) : Targeted(1) Gene trapped(1)
 

Male mice homozygous for a knock-out allele are viable but subfertile, as shown by reduced litter sizes or failure to produce a litter. Observed sperm abnormalities include heterogeneous chromatin condensation, loose acrosomes, and blunted heads.

 

Gene Ontology (GO) classifications

All GO classifications: (23 annotations)

Process	cell cycle, cell division, ...
Component	chromosome, chromosome, centromeric region, ...
Function	ATP binding, kinase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (27)    Tissues (17)    Images (7)
Theiler Stages: 13, 19, 20, 21, 22, 23, 28

Assay Type	Results
RNA in situ	8
Northern blot	17
RT-PCR	2

cDNA source data(10)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(13) Genomic(2) cDNA(10) Primer pair(1)
Microarray probesets(6)

Other database links

Ensembl Gene Model	ENSMUSG00000070837 (Evidence)
Entrez Gene	20871 (Evidence)
UniGene	261572
DoTS	DT.103584149, DT.40148768, DT.40149794, DT.94233532, DT.94233533
EC	2.7.11.1
Consensus CDS Project	CCDS39754.1
International Mouse Knockout Project Status	Aurkc

Sequences

Length	Strain/Species
genomic	ENSMUSG00000070837	Ensembl Gene Model | MGI Sequence Detail	7503	C57BL/6J
transcript	ENSMUST00000086248	Ensembl | MGI Sequence Detail	948	Not Applicable
polypeptide	ENSMUSP00000083426	Ensembl | MGI Sequence Detail	315	Not Applicable

All sequences(27) RefSeq(6) UniProt(4)

Polymorphisms

RFLP(1) : SNPs(82 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017441	Protein kinase, ATP binding site
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR002290	Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro	IPR008271	Serine/threonine-protein kinase, active site
Protein Ontology	PR:000004518	aurora kinase C

References

(Earliest) J:50717 Tseng TC, et al., Protein kinase profile of sperm and eggs: cloning and characterization of two novel testis-specific protein kinases (AIE1, AIE2) related to yeast and fly chromosome segregation regulators. DNA Cell Biol. 1998 Oct;17(10):823-33
(Latest) J:188537 Schindler K, et al., Maternally recruited Aurora C kinase is more stable than Aurora B to support mouse oocyte maturation and early development. Proc Natl Acad Sci U S A. 2012 Aug 14;109(33):E2215-22
All references(35)