About   Help   FAQ
Aurkc Gene Detail
Summary
  • Symbol
    Aurkc
  • Name
    aurora kinase C
  • Synonyms
    AIE1, AIK3, IAK3, Stk13
  • Feature Type
    protein coding gene
  • IDs
    MGI:1321119
    NCBI Gene: 20871
  • Gene Overview
    MyGene.info: AURKC
Location & Maps
more
  • Genetic Map
    Chromosome 7, 4.06 cM, cytoband A2-A3
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    AURKC, aurora kinase C
  • Vertebrate Orthologs
    6
  • Human Ortholog
    AURKC, aurora kinase C
    Orthology source: HomoloGene
  • Synonyms
    AIE2, AIK3, ARK3, AurC, aurora-C, HEL-S-90, SPGF5, STK13
  • Links
    NCBI Gene ID: 6795
    neXtProt AC: NX_Q9UQB9

  • Chr Location
    19q13.43; chr19:57230360-57235550 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human AURKC associations

Human Disease Mouse Models
       Spermatogenic Failure 5; SPGF5   OMIM: 243060
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Male mice homozygous for a knock-out allele are viable but subfertile, as shown by reduced litter sizes or failure to produce a litter. Observed sperm abnormalities include heterogeneous chromatin condensation, loose acrosomes, and blunted heads.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000060137 VEGA Gene Model | MGI Sequence Detail 7792 C57BL/6J ±  kb
transcript OTTMUST00000147197 VEGA | MGI Sequence Detail 1154 Not Applicable  
polypeptide OTTMUSP00000076608 VEGA | MGI Sequence Detail 315 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    87 from dbSNP Build 142
  • RFLP
Molecular
Reagents
less
  • All nucleic 13
    Genomic 2
    cDNA 10
    Primer pair 1

    Microarray probesets 6
References
more
  • Summaries
    All 32
    Developmental Gene Expression 4
    Gene Ontology 4
    Phenotypes 4
  • Earliest
    J:50717 Tseng TC, et al., Protein kinase profile of sperm and eggs: cloning and characterization of two novel testis-specific protein kinases (AIE1, AIE2) related to yeast and fly chromosome segregation regulators. DNA Cell Biol. 1998 Oct;17(10):823-33
  • Latest
    J:211004 Balboula AZ, et al., Selective disruption of aurora C kinase reveals distinct functions from aurora B kinase during meiosis in mouse oocytes. PLoS Genet. 2014 Feb;10(2):e1004194

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/23/2016
MGI 6.05
The Jackson Laboratory