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Bmp15 Gene Detail
Summary
  • Symbol
    Bmp15
  • Name
    bone morphogenetic protein 15
  • Synonyms
    Bmp-15, GDF-9B
  • Feature Type
    protein coding gene
  • IDs
    MGI:1316745
    NCBI Gene: 12155
  • Gene Overview
    MyGene.info: BMP15
Location & Maps
more
  • Genetic Map
    Chromosome X, 2.81 cM
  • Mapping Data
    2 experiments
Homology
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  • Human Ortholog
    BMP15, bone morphogenetic protein 15
  • Vertebrate Orthologs
    10
  • Human Ortholog
    BMP15, bone morphogenetic protein 15
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GDF9B, ODG2, POF4
  • Links
    NCBI Gene ID: 9210
    neXtProt AC: NX_O95972

  • Chr Location
    Xp11.22; chrX:50910735-50916641 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human BMP15 associations

Human Disease Mouse Models
       Ovarian Dysgenesis 2; ODG2   OMIM: 300510
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 1 allele in 3 genetic backgrounds
    14 phenotypes from multigenic genotypes
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    3
  • Targeted
    3
Homozygous mutation of this gene results in female infertility or reduced female fertility and small litter size depending on the genetic background. Mutant females exhibit abnormalities in folliculogenesis, ovulation, and oocyte morphology.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016662 VEGA Gene Model | MGI Sequence Detail 6615 C57BL/6J ±  kb
transcript OTTMUST00000040332 VEGA | MGI Sequence Detail 3060 Not Applicable  
polypeptide OTTMUSP00000018020 VEGA | MGI Sequence Detail 392 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    35 from dbSNP Build 142
Protein
Information
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Molecular
Reagents
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  • All nucleic 46
    cDNA 42
    Primer pair 4

    Microarray probesets 7
Other
Accession IDs
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MGI:2147951, MGI:2147957, MGI:2147964, MGI:2148078, MGI:2148080
References
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  • Summaries
    All 55
    Developmental Gene Expression 11
    Gene Ontology 5
    Phenotypes 8
  • Earliest
    J:51220 Dube JL, et al., The bone morphogenetic protein 15 gene is X-linked and expressed in oocytes. Mol Endocrinol. 1998 Dec;12(12):1809-17
  • Latest
    J:226026 Deuve JL, et al., Antagonist Xist and Tsix co-transcription during mouse oogenesis and maternal Xist expression during pre-implantation development calls into question the nature of the maternal imprint on the X chromosome. Epigenetics. 2015 Oct 3;10(10):931-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory