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Bmp15
Gene Detail
Symbol

Name
ID
Bmp15
bone morphogenetic protein 15
MGI:1316745
Synonyms
Bmp-15, GDF-9B
Feature Type
protein coding gene
Genetic Map
Chromosome X
2.81 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
ChrX:6314107-6320721 bp, - strand
From VEGA annotation of GRCm38

  6615 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3977  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: BMP15
Protein SuperFamily: growth/differentiation factor, GDF9/GDF9B type
Gene Tree: Bmp15

Human
homologs
BMP15, bone morphogenetic protein 15
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 9210
neXtProt AC: NX_O95972

Human Synonyms: GDF9B, ODG2, POF4

Human Chr (Location): Xp11.2; chrX:50910735-50916641 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human BMP15

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
 
Homozygous mutation of this gene results in female infertility or reduced female fertility and small litter size depending on the genetic background. Mutant females exhibit abnormalities in folliculogenesis, ovulation, and oocyte morphology.
 
Interactions
Bmp15 interacts with 193 markers (Mir1b, Mir16-1, Mir22, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process BMP signaling pathway, cell development, ...
Component cytoplasm, extracellular region, ...
Function cytokine activity, growth factor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (10 records)
Data Summary: Results (137)    Tissues (87)    Images (19)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 90
RT-PCR 47
cDNA source data(42)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase bmp15 ; ZFIN bmp15    NEW 
Molecular
reagents
All nucleic(46) cDNA(42) Primer pair(4)
Microarray probesets(7)
Other database
links
VEGA Gene Model OTTMUSG00000016662 (Evidence)
Ensembl Gene Model ENSMUSG00000023279 (Evidence)
Entrez Gene 12155 (Evidence)
UniGene 42160
DFCI TC1575186
DoTS DT.97410317
NIA Mouse Gene Index U044151
Consensus CDS Project CCDS29958.1
International Mouse Phenotyping Consortium Status Bmp15
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016662 VEGA Gene Model | MGI Sequence Detail 6615 C57BL/6J ±  kb
transcript OTTMUST00000040332 VEGA | MGI Sequence Detail 3060 Not Applicable 
polypeptide OTTMUSP00000018020 VEGA | MGI Sequence Detail 392 Not Applicable 

For the selected sequences
All sequences(37) RefSeq(2) UniProt(3)
Polymorphisms
SNPs within 2kb(35 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR015923 Bone morphogenetic protein 15
InterPro IPR002405 Inhibin, alpha subunit
InterPro IPR017948 Transforming growth factor beta, conserved site
InterPro IPR001839 Transforming growth factor-beta, C-terminal
InterPro IPR015615 Transforming growth factor-beta-related
Protein Ontology PR:000004772 bone morphogenetic protein 15
References
(Earliest) J:51220 Dube JL, et al., The bone morphogenetic protein 15 gene is X-linked and expressed in oocytes. Mol Endocrinol. 1998 Dec;12(12):1809-17
(Latest) J:221341 Lun MP, et al., Spatially heterogeneous choroid plexus transcriptomes encode positional identity and contribute to regional CSF production. J Neurosci. 2015 Mar 25;35(12):4903-16
All references(56)
Other
accession IDs
MGI:2147951, MGI:2147957, MGI:2147964, MGI:2148078, MGI:2148080

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory