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Bmp15
Gene Detail
 Symbol
Name
ID
Bmp15
bone morphogenetic protein 15
MGI:1316745
Synonyms Bmp-15, GDF-9B
Feature Type protein coding gene
Genetic Map
Chromosome X
2.81 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
ChrX:6314107-6320721 bp, - strand
From VEGA annotation of GRCm38

  6615 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3977  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: growth/differentiation factor, GDF9/GDF9B type
Gene Tree: Bmp15

Human
homologs
Human Homolog BMP15, bone morphogenetic protein 15
NCBI Gene ID 9210
neXtProt AC  NX_O95972
Human Synonyms  GDF9B, ODG2, POF4
Human Chr (Location)  Xp11.2; chrX:50910735-50916641 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human BMP15
Alleles
and
phenotypes
All alleles(3) : Targeted(3)
 
Homozygous mutation of this gene results in female infertility or reduced female fertility and small litter size depending on the genetic background. Mutant females exhibit abnormalities in folliculogenesis, ovulation, and oocyte morphology.
 
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process granulosa cell development, ovarian follicle development, ...
Component cytoplasm, extracellular region, ...
Function cytokine activity, growth factor activity
External Resources: FuncBase
Expression
Literature Summary: (9 records)
Data Summary: Results (137)    Tissues (87)    Images (19)
Theiler Stages: 2, 3, 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
RNA in situ 90
RT-PCR 47
cDNA source data(42)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(46) cDNA(42) Primer pair(4)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000016662 (Evidence)
Ensembl Gene ModelENSMUSG00000023279 (Evidence)
Entrez Gene12155 (Evidence)
UniGene42160
DFCITC1575186
DoTSDT.97410317
NIA Mouse Gene IndexU044151
Consensus CDS ProjectCCDS29958.1
International Mouse Knockout Project StatusBmp15
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016662 VEGA Gene Model | MGI Sequence Detail 6615 C57BL/6J ±  kb
transcript OTTMUST00000040332 VEGA | MGI Sequence Detail 3060 Not Applicable 
polypeptide OTTMUSP00000018020 VEGA | MGI Sequence Detail 392 Not Applicable 

For the selected sequences
All sequences(37) RefSeq(2) UniProt(3)
Polymorphisms SNPs within 2kb(35 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR015923 Bone morphogenetic protein 15
InterPro IPR002405 Inhibin, alpha subunit
InterPro IPR017948 Transforming growth factor beta, conserved site
InterPro IPR001839 Transforming growth factor-beta, C-terminal
InterPro IPR015615 Transforming growth factor-beta-related
Protein Ontology PR:000004772 bone morphogenetic protein 15
References (Earliest) J:51220 Dube JL, et al., The bone morphogenetic protein 15 gene is X-linked and expressed in oocytes. Mol Endocrinol. 1998 Dec;12(12):1809-17
(Latest) J:205485 Yu C, et al., CRL4 complex regulates mammalian oocyte survival and reprogramming by activation of TET proteins. Science. 2013 Dec 20;342(6165):1518-21
All references(55)
Other
accession IDs
MGI:2147951, MGI:2147957, MGI:2147964, MGI:2148078, MGI:2148080

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory