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St3gal4
Gene Detail
 Symbol
Name
ID
St3gal4
ST3 beta-galactoside alpha-2,3-sialyltransferase 4
MGI:1316743
Synonyms Siat4c, ST3Gal IV
Feature Type protein coding gene
Genetic Map
Chromosome 9
19.36 cM, cytoband A5.3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr9:35046579-35116810 bp, - strand
From NCBI annotation of GRCm38

  70232 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4572  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: sialyltransferase
Gene Tree: St3gal4

Human
homologs
Human Homolog ST3GAL4, ST3 beta-galactoside alpha-2,3-sialyltransferase 4
NCBI Gene ID 6484
neXtProt AC  NX_Q11206
Human Synonyms  CGS23, NANTA3, SAT3, SIAT4, SIAT4C, ST3GalIV, STZ
Human Chr (Location)  11q24.2; chr11:126355645-126414641 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(13) : Gene trapped(9) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele display low platelet counts, altered platelet clearance by hepatocytes, prolonged bleeding times, and absence of L-selectin mediated leukocyte rolling.
 
Interactions
St3gal4 interacts with 114 markers (Mir7-1, Mir10a, Mir10b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process cognition, protein glycosylation, ...
Component extracellular vesicular exosome, Golgi apparatus, ...
Function beta-galactoside (CMP) alpha-2,3-sialyltransferase activity, lytic endotransglycosylase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (134)    Tissues (108)    Images (4)
Theiler Stages: 12, 22, 28
Assay TypeResults
RNA in situ 94
Northern blot 27
RT-PCR 13
cDNA source data(56)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(58) cDNA(57) Primer pair(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000032038 (Evidence)
Entrez Gene20443 (Evidence)
UniGene275973
DFCITC1578703, TC1593390
NIA Mouse Gene IndexU030659
EC2.4.99.-
Consensus CDS ProjectCCDS22956.1
International Mouse Knockout Project StatusSt3gal4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 20443 NCBI Gene Model | MGI Sequence Detail 70232 C57BL/6J ±  kb
transcript NM_009178 RefSeq | MGI Sequence Detail 2059 Not Specified 
polypeptide Q91Y74 UniProt | EBI | MGI Sequence Detail 333 Not Applicable 

For the selected sequences
All sequences(40) RefSeq(20) UniProt(5)
Polymorphisms SNPs within 2kb(394 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001675 Glycosyl transferase, family 29
InterPro IPR012163 Sialyltransferase
Protein Ontology PR:000030638 CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4
Graphical View of Protein Domain Structure
References (Earliest) J:41275 Kono M, et al., Mouse beta-galactoside alpha 2,3-sialyltransferases: comparison of in vitro substrate specificities and tissue specific expression. Glycobiology. 1997 Jun;7(4):469-79
(Latest) J:204203 Doring Y, et al., Deficiency of the Sialyltransferase St3Gal4 Reduces Ccl5-Mediated Myeloid Cell Recruitment and Arrest. Circ Res. 2014 Jan 14;
All references(49)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory