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St3gal4
Gene Detail
Symbol

Name
ID
St3gal4
ST3 beta-galactoside alpha-2,3-sialyltransferase 4
MGI:1316743
Synonyms
Siat4c, ST3Gal IV
Feature Type
protein coding gene
Genetic Map
Chromosome 9
19.36 cM, cytoband A5.3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr9:35046579-35116810 bp, - strand
From Ensembl annotation of GRCm38

  70232 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4572  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: ST3GAL4
Protein SuperFamily: sialyltransferase
Gene Tree: St3gal4

Human
homologs
ST3GAL4, ST3 beta-galactoside alpha-2,3-sialyltransferase 4
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 6484
neXtProt AC: NX_Q11206

Human Synonyms: CGS23, NANTA3, SAT3, SIAT4, SIAT4C, ST3GalIV, STZ

Human Chr (Location): 11q24.2; chr11:126355645-126652917 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(13) : Gene trapped(9) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele display low platelet counts, altered platelet clearance by hepatocytes, prolonged bleeding times, and absence of L-selectin mediated leukocyte rolling.
 
Interactions
St3gal4 interacts with 114 markers (Mir7-1, Mir10a, Mir10b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (3 records)
Data Summary: Results (134)    Tissues (115)    Images (4)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 94
Northern blot 27
RT-PCR 13
cDNA source data(56)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase st3gal4    NEW 
Molecular
reagents
All nucleic(58) cDNA(57) Primer pair(1)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000032038 (Evidence)
Entrez Gene 20443 (Evidence)
UniGene 275973
DFCI TC1578703, TC1593390
NIA Mouse Gene Index U030659
EC 2.4.99.-
Consensus CDS Project CCDS22956.1
International Mouse Phenotyping Consortium Status St3gal4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000032038 Ensembl Gene Model | MGI Sequence Detail 70232 C57BL/6J ±  kb
transcript ENSMUST00000034537 Ensembl | MGI Sequence Detail 2029 Not Applicable 
polypeptide ENSMUSP00000034537 Ensembl | MGI Sequence Detail 333 Not Applicable 

For the selected sequences
All sequences(46) RefSeq(26) UniProt(5)
Polymorphisms
SNPs within 2kb(394 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001675 Glycosyl transferase, family 29
InterPro IPR012163 Sialyltransferase
Protein Ontology PR:000030638 CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4
References
(Earliest) J:41275 Kono M, et al., Mouse beta-galactoside alpha 2,3-sialyltransferases: comparison of in vitro substrate specificities and tissue specific expression. Glycobiology. 1997 Jun;7(4):469-79
(Latest) J:219348 Ednie AR, et al., Reduced sialylation impacts ventricular repolarization by modulating specific K+ channel isoforms distinctly. J Biol Chem. 2015 Jan 30;290(5):2769-83
All references(50)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory