St3gal4
Gene Detail

Symbol Name ID

St3gal4 ST3 beta-galactoside alpha-2,3-sialyltransferase 4 MGI:1316743

Synonyms

Siat4c, ST3Gal IV

Feature Type

protein coding gene

Genetic Map

Chromosome 9

19.36 cM, cytoband A5.3
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr9:35046579-35116810 bp, - strand From NCBI annotation of GRCm38   70232 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:4572  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: sialyltransferase
Gene Tree: St3gal4

Human homologs

Human Homolog		ST3GAL4, ST3 beta-galactoside alpha-2,3-sialyltransferase 4
NCBI Gene ID		6484
neXtProt AC		NX_Q11206
Human Synonyms		CGS23, NANTA3, SAT3, SIAT4, SIAT4C, ST3GalIV, STZ
Human Chr (Location)		11q24.2; chr11:126225540-126284536 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(13) : Targeted(4) Gene trapped(9)
 

Mice homozygous for a knock-out allele display low platelet counts, altered platelet clearance by hepatocytes, prolonged bleeding times, and absence of L-selectin mediated leukocyte rolling.

 

Gene Ontology (GO) classifications

All GO classifications: (10 annotations)

Process	protein glycosylation
Component	Golgi apparatus, integral to Golgi membrane, ...
Function	beta-galactoside (CMP) alpha-2,3-sialyltransferase activity, monosialoganglioside sialyltransferase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (134)    Tissues (108)    Images (4)
Theiler Stages: 12, 22, 28

Assay Type	Results
RNA in situ	94
Northern blot	27
RT-PCR	13

cDNA source data(55)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(57) cDNA(56) Primer pair(1)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000032038 (Evidence)
Entrez Gene	20443 (Evidence)
UniGene	275973
DFCI	TC1578703, TC1593390
NIA Mouse Gene Index	U030659
EC	2.4.99.-
Consensus CDS Project	CCDS22956.1
International Mouse Knockout Project Status	St3gal4

Sequences

Length	Strain/Species
genomic	20443	NCBI Gene Model | MGI Sequence Detail	70232	C57BL/6J
transcript	NM_009178	RefSeq | MGI Sequence Detail	2059	Not Specified
polypeptide	Q91Y74	UniProt | EBI | MGI Sequence Detail	333	Not Applicable

All sequences(22) RefSeq(2) UniProt(5)

Polymorphisms

SNPs(210 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001675	Glycosyl transferase, family 29
InterPro	IPR012163	Sialyltransferase
Protein Ontology	PR:000030638	CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4

Graphical View of Protein Domain Structure

References

(Earliest) J:41275 Kono M, et al., Mouse beta-galactoside alpha 2,3-sialyltransferases: comparison of in vitro substrate specificities and tissue specific expression. Glycobiology. 1997 Jun;7(4):469-79
(Latest) J:189127 Wandall HH, et al., The origin and function of platelet glycosyltransferases. Blood. 2012 Jul 19;120(3):626-35
All references(45)