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St3gal4 Gene Detail
Summary
  • Symbol
    St3gal4
  • Name
    ST3 beta-galactoside alpha-2,3-sialyltransferase 4
  • Synonyms
    Siat4c, ST3Gal IV
  • Feature Type
    protein coding gene
  • IDs
    MGI:1316743
    NCBI Gene: 20443
  • Gene Overview
    MyGene.info: ST3GAL4
Location & Maps
more
  • Sequence Map
    Chr9:35046579-35116810 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      70232 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    ST3GAL4, ST3 beta-galactoside alpha-2,3-sialyltransferase 4
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ST3GAL4, ST3 beta-galactoside alpha-2,3-sialyltransferase 4
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CGS23, NANTA3, SAT3, SIAT4, SIAT4C, ST3GalIV, STZ
  • Links
    NCBI Gene ID: 6484
    neXtProt AC: NX_Q11206

  • Chr Location
    11q24.2; chr11:126355645-126652917 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 1 allele in 2 genetic backgrounds
    11 phenotypes from multigenic genotypes
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    16
  • Gene trapped
    9
  • Targeted
    7
  • Incidental Mutations
Mice homozygous for a knock-out allele display low platelet counts, altered platelet clearance by hepatocytes, prolonged bleeding times, and absence of L-selectin mediated leukocyte rolling.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000032038 Ensembl Gene Model | MGI Sequence Detail 70232 C57BL/6J ±  kb
transcript ENSMUST00000034537 Ensembl | MGI Sequence Detail 2029 Not Applicable  
polypeptide ENSMUSP00000034537 Ensembl | MGI Sequence Detail 333 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    392 from dbSNP Build 142
Protein
Information
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  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000030638 CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4
  • EC
  • InterPro Domains
    IPR001675 Glycosyl transferase family 29
    IPR012163 Sialyltransferase
Molecular
Reagents
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  • All nucleic 58
    cDNA 57
    Primer pair 1

    Microarray probesets 3
References
more
  • Summaries
    All 53
    Developmental Gene Expression 3
    Gene Ontology 7
    Phenotypes 24
  • Earliest
    J:41275 Kono M, et al., Mouse beta-galactoside alpha 2,3-sialyltransferases: comparison of in vitro substrate specificities and tissue specific expression. Glycobiology. 1997 Jun;7(4):469-79
  • Latest
    J:229186 Kato K, Differential effects of dietary oils on emotional and cognitive behaviors. PLoS One. 2015;10(3):e0120753

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory