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Lgals7 Gene Detail
Summary
  • Symbol
    Lgals7
  • Name
    lectin, galactose binding, soluble 7
  • Synonyms
    Galectin-7, Pig1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1316742
    NCBI Gene: 16858
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:28863853-28866284 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 16.94 cM, cytoband A3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    175 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1316742
protein coding gene Chr7:28863853-28866285 (.)
129S1/SvImJ MGP_129S1SvImJ_G0031965
protein coding gene Chr7:27737456-27739887 (+)
A/J MGP_AJ_G0031943
protein coding gene Chr7:27016411-27018842 (+)
AKR/J MGP_AKRJ_G0031875
protein coding gene Chr7:27714596-27717027 (+)
BALB/cJ MGP_BALBcJ_G0031950
protein coding gene Chr7:27173004-27175435 (+)
C3H/HeJ MGP_C3HHeJ_G0031669
protein coding gene Chr7:28117908-28120339 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032414
protein coding gene Chr7:28617843-28620274 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029466
protein coding gene Chr7:28078505-28080956 (+)
CAST/EiJ MGP_CASTEiJ_G0031004
protein coding gene Chr7:21414747-21417178 (+)
CBA/J MGP_CBAJ_G0031635
protein coding gene Chr7:29935652-29938083 (+)
DBA/2J MGP_DBA2J_G0031787
protein coding gene Chr7:26764830-26767261 (+)
FVB/NJ MGP_FVBNJ_G0031744
protein coding gene Chr7:26853637-26856067 (+)
LP/J MGP_LPJ_G0031867
protein coding gene Chr7:28037216-28039647 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031780
protein coding gene Chr7:29366381-29368812 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032444
protein coding gene Chr7:27193302-27195733 (+)
PWK/PhJ MGP_PWKPhJ_G0030729
protein coding gene Chr7:21802189-21804620 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030562
protein coding gene Chr7:18214442-18216867 (+)
WSB/EiJ MGP_WSBEiJ_G0031113
protein coding gene Chr7:27570522-27572952 (+)



Homology
more
  • Human Ortholog
    LGALS7, galectin 7
  • Vertebrate Orthologs
    9
  • Human Ortholog
    LGALS7, galectin 7
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GAL7, LGALS7A
  • Links
    NCBI Gene ID: 3963
    neXtProt AC: NX_P47929

  • Chr Location
    19q13.2; chr19:38770968-38773517 (-)  GRCh38.p7

  • Human Ortholog
    LGALS7B, galectin 7B
    Orthology source: HomoloGene, HGNC
  • Synonyms
    Gal-7, GAL7, HKL-14, LGALS7, PI7
  • Links
    NCBI Gene ID: 653499
    neXtProt AC: NX_P47929
    UniProt: P47929

  • Chr Location
    19q13.2; chr19:38789210-38791754 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000053522 Ensembl Gene Model | MGI Sequence Detail 2432 C57BL/6J ±  kb
    transcript ENSMUST00000081457 Ensembl | MGI Sequence Detail 754 Not Applicable  
    polypeptide ENSMUSP00000080179 Ensembl | MGI Sequence Detail 136 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • InterPro Domains
      IPR013320 Concanavalin A-like lectin/glucanase domain superfamily
      IPR030640 Galectin-7
      IPR001079 Galectin, carbohydrate recognition domain
    Molecular
    Reagents
    less
    • All nucleic 11
      cDNA 10
      Primer pair 1

      Microarray probesets 4
    References
    more
    • Summaries
      All 38
      Developmental Gene Expression 4
      Gene Ontology 2
      Phenotypes 10
    • Earliest
      J:49734 Magnaldo T, et al., Galectin-7, a marker of all types of stratified epithelia. Differentiation. 1998 Jul;63(3):159-68
    • Latest
      J:250910 Grosset AA, et al., Galectin-7 Expression Potentiates HER-2-Positive Phenotype in Breast Cancer. PLoS One. 2016;11(11):e0166731

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory