Clca1
Gene Detail

Symbol Name ID

Clca1 chloride channel calcium activated 1 MGI:1316732

Feature Type

protein coding gene

Genetic Map

Chromosome 3

69.06 cM, cytoband H2-H3
Detailed Genetic Map ± 1 cM


Mapping data(6)

Sequence Map

Chr3:144729677-144760977 bp, - strand From VEGA annotation of GRCm38   31301 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:74932  Vertebrate Homology Class
2 mouse; 1 rat

Protein SuperFamily: calcium-activated chloride channel
Gene Tree: Clca1

Gene Ontology (GO) classifications

All GO classifications: (4 annotations)

Process	chloride transport, ion transmembrane transport
Component	integral to plasma membrane
Function	intracellular calcium activated chloride channel activity

External Resources: FuncBase

Expression

Literature Summary: (6 records)
Data Summary: Results (294)    Tissues (96)    Images (67)
Theiler Stages: 13, 20, 21, 23, 24, 25, 26, 28

Assay Type	Results
RNA in situ	245
RT-PCR	49

cDNA source data(18)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(27) cDNA(19) Primer pair(7) Other(1)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000026564 (Evidence)
Ensembl Gene Model	ENSMUSG00000056025 (Evidence)
Entrez Gene	12722 (Evidence)
Consensus CDS Project	CCDS17886.1
International Mouse Knockout Project Status	Clca1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000026564	VEGA Gene Model | MGI Sequence Detail	31301	C57BL/6J
transcript	OTTMUST00000065726	VEGA | MGI Sequence Detail	3524	Not Applicable
polypeptide	OTTMUSP00000032793	VEGA | MGI Sequence Detail	902	Not Applicable

All sequences(40) RefSeq(2) UniProt(7)

Polymorphisms

SNPs(139 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR004727	Calcium-activated chloride channel protein
InterPro	IPR013642	Chloride channel calcium-activated
InterPro	IPR015394	Domain of unknown function DUF1973
InterPro	IPR002035	von Willebrand factor, type A

References

(Earliest) J:5128 Stewart AD, et al., Studies on syndrome of diabetes insipidus associated with oligosyndactyly in mice. Am J Physiol. 1969 Oct;217(4):1191-8
(Latest) J:187011 Rajagopal M, et al., Differential effects of extracellular ATP on chloride transport in cortical collecting duct cells. Am J Physiol Renal Physiol. 2012 Aug;303(4):F483-91
All references(31)