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Clca1
Gene Detail
 Symbol
Name
ID
Clca1
chloride channel calcium activated 1
MGI:1316732
Feature Type protein coding gene
Genetic Map
Chromosome 3
69.06 cM, cytoband H2-H3
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr3:144729677-144760977 bp, - strand
From VEGA annotation of GRCm38

  31301 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:77224  Vertebrate Homology Class
2 mouse; 1 rat; 1 rhesus macaque; 2 cattle; 1 dog; 1 chicken; 5 western clawed frog; 1 zebrafish

Protein SuperFamily: calcium-activated chloride channel
Gene Tree: Clca1

Mutations,
alleles, and
phenotypes
Incidental mutations (data from Mutagenetix , APF )
Interactions
Clca1 interacts with 288 markers (Mir7b, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (4 annotations)
Process chloride transmembrane transport, chloride transport
Component integral component of plasma membrane
Function intracellular calcium activated chloride channel activity
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (294)    Tissues (98)    Images (67)
Theiler Stages: 13, 20, 21, 23, 24, 25, 26, 27, 28
Assay TypeResults
RNA in situ 245
RT-PCR 49
cDNA source data(18)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(27) cDNA(19) Primer pair(7) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000026564 (Evidence)
Ensembl Gene ModelENSMUSG00000056025 (Evidence)
Entrez Gene12722 (Evidence)
Consensus CDS ProjectCCDS17886.1
International Mouse Knockout Project StatusClca1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026564 VEGA Gene Model | MGI Sequence Detail 31301 C57BL/6J ±  kb
transcript OTTMUST00000065726 VEGA | MGI Sequence Detail 3524 Not Applicable 
polypeptide OTTMUSP00000032793 VEGA | MGI Sequence Detail 902 Not Applicable 

For the selected sequences
All sequences(49) RefSeq(11) UniProt(7)
Polymorphisms SNPs within 2kb(250 from dbSNP Build 137)    SNPs within 2kb including multiple locations(284)
Protein-related
information
ResourceIDDescription
InterPro IPR004727 Calcium-activated chloride channel protein
InterPro IPR013642 Chloride channel calcium-activated
InterPro IPR015394 Domain of unknown function DUF1973
InterPro IPR002035 von Willebrand factor, type A
References (Earliest) J:5128 Stewart AD, et al., Studies on syndrome of diabetes insipidus associated with oligosyndactyly in mice. Am J Physiol. 1969 Oct;217(4):1191-8
(Latest) J:187011 Rajagopal M, et al., Differential effects of extracellular ATP on chloride transport in cortical collecting duct cells. Am J Physiol Renal Physiol. 2012 Aug;303(4):F483-91
All references(31)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory