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Gspt1 Gene Detail
Summary
  • Symbol
    Gspt1
  • Name
    G1 to S phase transition 1
  • Synonyms
    G1st, Gst-1, Gst-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1316728
    NCBI Gene: 14852
  • Gene Overview
    MyGene.info: GSPT1
  • Alliance
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:11219292-11254325 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 6.38 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    145 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1316728
protein coding gene Chr16:11216240-11254325 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022523
protein coding gene Chr16:8084613-8120634 (-)
A/J MGP_AJ_G0022485
protein coding gene Chr16:7634315-7670171 (-)
AKR/J MGP_AKRJ_G0022461
protein coding gene Chr16:7987402-8030833 (-)
BALB/cJ MGP_BALBcJ_G0022489
protein coding gene Chr16:7778292-7812943 (-)
C3H/HeJ MGP_C3HHeJ_G0022256
protein coding gene Chr16:8061344-8098960 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022938
protein coding gene Chr16:8242971-8280841 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020458
protein coding gene Chr16:7797845-7832363 (-)
CAST/EiJ MGP_CASTEiJ_G0021783
protein coding gene Chr16:8086332-8120269 (-)
CBA/J MGP_CBAJ_G0022225
protein coding gene Chr16:8595760-8632631 (-)
DBA/2J MGP_DBA2J_G0022356
protein coding gene Chr16:7639068-7673236 (-)
FVB/NJ MGP_FVBNJ_G0022332
protein coding gene Chr16:7631672-7666116 (-)
LP/J MGP_LPJ_G0022424
protein coding gene Chr16:8032261-8067187 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022354
protein coding gene Chr16:8290454-8330568 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022951
protein coding gene Chr16:7932617-7967145 (-)
PWK/PhJ MGP_PWKPhJ_G0021523
protein coding gene Chr16:7869336-7906146 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021353
protein coding gene Chr16:7997851-8038413 (-)
WSB/EiJ MGP_WSBEiJ_G0021831
protein coding gene Chr16:8020071-8055943 (-)



Homology
more
  • Human Ortholog
    GSPT1, G1 to S phase transition 1
  • Vertebrate Orthologs
    12
  • Human Ortholog
    GSPT1, G1 to S phase transition 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    551G9.2, eRF3a, ETF3A, GST1
  • Links
    NCBI Gene ID: 2935
    neXtProt AC: NX_P15170
    UniProt: P15170

  • Chr Location
    16p13.13; chr16:11868128-11916662 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 68226
    1 human;1 mouse;2 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: GSPT1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotype references
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000062203 Ensembl Gene Model | MGI Sequence Detail 35034 C57BL/6J ±  kb
transcript ENSMUST00000080030 Ensembl | MGI Sequence Detail 2898 Not Applicable  
polypeptide ENSMUSP00000078940 Ensembl | MGI Sequence Detail 636 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000008290 eukaryotic peptide chain release factor GTP-binding subunit ERF3A
  • PDB
  • InterPro Domains
    IPR009818 Ataxin-2, C-terminal
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
    IPR005225 Small GTP-binding protein domain
    IPR000795 Transcription factor, GTP-binding domain
    IPR009001 Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal
    IPR004160 Translation elongation factor EFTu/EF1A, C-terminal
    IPR004161 Translation elongation factor EFTu-like, domain 2
    IPR009000 Translation protein, beta-barrel domain superfamily
    IPR031157 Tr-type G domain, conserved site
Molecular
Reagents
less
  • All nucleic 25
    cDNA 25

    Microarray probesets 6
Other
Accession IDs
less
MGD-MRK-10304, MGD-MRK-9913, MGI:2146405, MGI:2146418, MGI:2146605, MGI:2146705, MGI:95605
References
more
  • Summaries
    All 39
    Gene Ontology 6
    Phenotypes 6
  • Earliest
    J:10106 Hoshino S, et al., A human homologue of the yeast GST1 gene codes for a GTP-binding protein and is expressed in a proliferation-dependent manner in mammalian cells. EMBO J. 1989 Dec 1;8(12):3807-14
  • Latest
    J:239233 Ishii T, et al., A Novel Rac1-GSPT1 Signaling Pathway Controls Astrogliosis Following Central Nervous System Injury. J Biol Chem. 2017 Jan 27;292(4):1240-1250

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory