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Fga Gene Detail
Summary
  • Symbol
    Fga
  • Name
    fibrinogen alpha chain
  • Synonyms
    ENSMUSG00000059807, Fib
  • Feature Type
    protein coding gene
  • IDs
    MGI:1316726
    NCBI Gene: 14161
  • Gene Overview
    MyGene.info: FGA
Location & Maps
more
  • Sequence Map
    Chr3:83026076-83033627 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      7552 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 36.96 cM, cytoband F1
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    FGA, fibrinogen alpha chain
  • Vertebrate Orthologs
    9
  • Human Ortholog
    FGA, fibrinogen alpha chain
    Orthology source: HomoloGene, HGNC
  • Synonyms
    Fib2
  • Links
    NCBI Gene ID: 2243
    neXtProt AC: NX_P02671

  • Chr Location
    4q28; chr4:154583128-154590745 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 428
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: FGA
  • Gene Tree
    Fga
Human Diseases
more
  • Diseases
    3 with human FGA associations

Human Disease Mouse Models
       Afibrinogenemia, Congenital   OMIM: 202400
Amyloidosis, Familial Visceral   OMIM: 105200
Dysfibrinogenemia, Congenital   OMIM: 616004
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    17 phenotypes from 1 allele in 3 genetic backgrounds
    14 phenotypes from multigenic genotypes
    63 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    8
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Targeted
    4
  • Transgenic
    2
  • Genomic Mutations
    2 involving Fga
  • Incidental Mutations
Mice homozygous for disruptions of this gene have blood that is unable to clot. On some genetic backgrounds this can lead to fatal hemorrhaging.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000051803 VEGA Gene Model | MGI Sequence Detail 7552 C57BL/6J ±  kb
transcript OTTMUST00000130536 VEGA | MGI Sequence Detail 2587 Not Applicable  
polypeptide OTTMUSP00000069934 VEGA | MGI Sequence Detail 789 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    76 from dbSNP Build 142
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000007471 fibrinogen alpha chain
  • InterPro Domains
    IPR012290 Fibrinogen, alpha/beta/gamma chain, coiled coil domain
    IPR002181 Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
    IPR014716 Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1
    IPR014715 Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 2
    IPR021996 Fibrinogen alpha C domain
    IPR020837 Fibrinogen, conserved site
Molecular
Reagents
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  • All nucleic 197
    Genomic 1
    cDNA 193
    Primer pair 2
    Other 1

    Microarray probesets 4
Other
Accession IDs
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MGI:2139659, MGI:3642492
References
more
  • Summaries
    All 96
    Developmental Gene Expression 12
    Gene Ontology 6
    Phenotypes 63
  • Earliest
    J:15567 Warden CH, et al., Linkage mapping of 40 randomly isolated liver cDNA clones in the mouse. Genomics. 1993 Nov;18(2):295-307
  • Latest
    J:230685 Prasad JM, et al., Mice expressing a mutant form of fibrinogen that cannot support fibrin formation exhibit compromised antimicrobial host defense. Blood. 2015 Oct 22;126(17):2047-58

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory