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Fga
Gene Detail
 Symbol
Name
ID
Fga
fibrinogen alpha chain
MGI:1316726
Synonyms ENSMUSG00000059807, Fib
Feature Type protein coding gene
Genetic Map
Chromosome 3
36.96 cM, cytoband F1
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr3:83026153-83033615 bp, + strand
From Ensembl annotation of GRCm38

  7463 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:428  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Fga

Human
homologs
Human Homolog FGA, fibrinogen alpha chain
NCBI Gene ID 2243
neXtProt AC  NX_P02671
Human Synonyms  Fib2
Human Chr (Location)  4q28; chr4:154583128-154590745 (-)  GRCh38
Disease Associations  (3) Diseases Associated with Human FGA
Alleles
and
phenotypes
All alleles(3) : Targeted(3)
 
Mice homozygous for disruptions of this gene have blood that is unable to clot. On some genetic backgrounds this can lead to fatal hemorrhaging.
 
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process blood coagulation, response to calcium ion
Component blood microparticle, cell cortex, ...
External Resources: FuncBase
Expression
Literature Summary: (11 records)
Data Summary: Results (64)    Tissues (29)    Images (35)
Theiler Stages: 11, 12, 13, 15, 17, 19, 20, 21, 22, 23, 24, 25, 28
Assay TypeResults
Immunohistochemistry 30
RNA in situ 23
RT-PCR 11
cDNA source data(193)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(197) Genomic(1) cDNA(193) Primer pair(2) Other(1)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000028001 (Evidence)
Entrez Gene14161 (Evidence)
UniGene88793
DFCITC1574510, TC1651333
DoTSDT.40164731, DT.91432881, DT.94172791
NIA Mouse Gene IndexU003364
Consensus CDS ProjectCCDS17431.1, CCDS50939.1
International Mouse Knockout Project StatusFga
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000028001 Ensembl Gene Model | MGI Sequence Detail 7463 C57BL/6J ±  kb
transcript ENSMUST00000166581 Ensembl | MGI Sequence Detail 2637 Not Applicable 
polypeptide ENSMUSP00000133117 Ensembl | MGI Sequence Detail 789 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(4) UniProt(2)
Polymorphisms SNPs within 2kb(76 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR012290 Fibrinogen, alpha/beta/gamma chain, coiled coil domain
InterPro IPR002181 Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
InterPro IPR014716 Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1
InterPro IPR014715 Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 2
InterPro IPR021996 Fibrinogen alpha C domain
InterPro IPR020837 Fibrinogen, conserved site
Protein Ontology PR:000007471 fibrinogen alpha chain
References (Earliest) J:15567 Warden CH, et al., Linkage mapping of 40 randomly isolated liver cDNA clones in the mouse. Genomics. 1993 Nov;18(2):295-307
(Latest) J:200940 Sorensen-Zender I, et al., Role of fibrinogen in acute ischemic kidney injury. Am J Physiol Renal Physiol. 2013 Sep;305(5):F777-85
All references(89)
Other
accession IDs
MGI:2139659, MGI:3642492

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory