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Fga
Gene Detail
Symbol

Name
ID
Fga
fibrinogen alpha chain
MGI:1316726
Synonyms
ENSMUSG00000059807, Fib
Feature Type
protein coding gene
Genetic Map
Chromosome 3
36.96 cM, cytoband F1
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr3:83026076-83033627 bp, + strand
From VEGA annotation of GRCm38

  7552 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:428  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: FGA
Gene Tree: Fga

Human
homologs
FGA, fibrinogen alpha chain
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 2243
neXtProt AC: NX_P02671

Human Synonyms: Fib2

Human Chr (Location): 4q28; chr4:154583128-154590745 (-)  GRCh38.p2

Disease Associations: (3) Diseases Associated with Human FGA

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for disruptions of this gene have blood that is unable to clot. On some genetic backgrounds this can lead to fatal hemorrhaging.
 
Interactions
Fga interacts with 243 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (44 annotations)
Process adaptive immune response, blood coagulation, ...
Component blood microparticle, cell cortex, ...
Function cell adhesion molecule binding, protein binding, bridging, ...
External Resources: FuncBase
Expression
Literature Summary: (12 records)
Data Summary: Results (64)    Tissues (29)    Images (35)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 30
RNA in situ 23
RT-PCR 11
cDNA source data(193)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase fga ; ZFIN fga    NEW 
Molecular
reagents
All nucleic(197) Genomic(1) cDNA(193) Primer pair(2) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000051803 (Evidence)
Ensembl Gene Model ENSMUSG00000028001 (Evidence)
Entrez Gene 14161 (Evidence)
UniGene 88793
DFCI TC1574510, TC1651333
DoTS DT.40164731, DT.91432881, DT.94172791
NIA Mouse Gene Index U003364
Consensus CDS Project CCDS17431.1, CCDS50939.1
International Mouse Phenotyping Consortium Status Fga
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000051803 VEGA Gene Model | MGI Sequence Detail 7552 C57BL/6J ±  kb
transcript OTTMUST00000130536 VEGA | MGI Sequence Detail 2587 Not Applicable 
polypeptide OTTMUSP00000069934 VEGA | MGI Sequence Detail 789 Not Applicable 

For the selected sequences
All sequences(34) RefSeq(4) UniProt(1)
Polymorphisms
SNPs within 2kb(76 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR012290 Fibrinogen, alpha/beta/gamma chain, coiled coil domain
InterPro IPR002181 Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
InterPro IPR014716 Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1
InterPro IPR014715 Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 2
InterPro IPR021996 Fibrinogen alpha C domain
InterPro IPR020837 Fibrinogen, conserved site
Protein Ontology PR:000007471 fibrinogen alpha chain
References
(Earliest) J:15567 Warden CH, et al., Linkage mapping of 40 randomly isolated liver cDNA clones in the mouse. Genomics. 1993 Nov;18(2):295-307
(Latest) J:221213 Raghu H, et al., Transglutaminase factor XIII promotes arthritis through mechanisms linked to inflammation and bone erosion. Blood. 2015 Jan 15;125(3):427-37
All references(95)
Other
accession IDs
MGI:2139659, MGI:3642492

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory