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Fga
Gene Detail
Symbol

Name
ID
Fga
fibrinogen alpha chain
MGI:1316726
Synonyms
ENSMUSG00000059807, Fib
Feature Type
protein coding gene
Genetic Map
Chromosome 3
36.96 cM, cytoband F1
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr3:83026153-83033615 bp, + strand
From Ensembl annotation of GRCm38

  7463 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:428  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Fga

Human
homologs
Human Homolog FGA, fibrinogen alpha chain
NCBI Gene ID 2243
neXtProt AC  NX_P02671
Human Synonyms  Fib2
Human Chr (Location)  4q28; chr4:154583128-154590745 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human FGA
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions of this gene have blood that is unable to clot. On some genetic backgrounds this can lead to fatal hemorrhaging.
 
Interactions
Fga interacts with 244 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (36 annotations)
Process blood coagulation, blood coagulation, common pathway, ...
Component blood microparticle, cell cortex, ...
Function cell adhesion molecule binding, protein binding, bridging, ...
External Resources: FuncBase
Expression
Literature Summary: (11 records)
Data Summary: Results (64)    Tissues (29)    Images (35)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 30
RNA in situ 23
RT-PCR 11
cDNA source data(193)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(197) Genomic(1) cDNA(193) Primer pair(2) Other(1)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000028001 (Evidence)
Entrez Gene14161 (Evidence)
UniGene88793
DFCITC1651333, TC1574510
DoTSDT.94172791, DT.91432881, DT.40164731
NIA Mouse Gene IndexU003364
Consensus CDS ProjectCCDS17431.1, CCDS50939.1
International Mouse Knockout Project StatusFga
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000028001 Ensembl Gene Model | MGI Sequence Detail 7463 C57BL/6J ±  kb
transcript ENSMUST00000166581 Ensembl | MGI Sequence Detail 2637 Not Applicable 
polypeptide ENSMUSP00000133117 Ensembl | MGI Sequence Detail 789 Not Applicable 

For the selected sequences
All sequences(26) RefSeq(4) UniProt(1)
Polymorphisms
SNPs within 2kb(76 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR012290 Fibrinogen, alpha/beta/gamma chain, coiled coil domain
InterPro IPR002181 Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
InterPro IPR014716 Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1
InterPro IPR014715 Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 2
InterPro IPR021996 Fibrinogen alpha C domain
InterPro IPR020837 Fibrinogen, conserved site
Protein Ontology PR:000007471 fibrinogen alpha chain
References
(Earliest) J:15567 Warden CH, et al., Linkage mapping of 40 randomly isolated liver cDNA clones in the mouse. Genomics. 1993 Nov;18(2):295-307
(Latest) J:213634 Craciun FL, et al., Pharmacological and genetic depletion of fibrinogen protects from kidney fibrosis. Am J Physiol Renal Physiol. 2014 Aug 15;307(4):F471-84
All references(92)
Other
accession IDs
MGI:2139659, MGI:3642492

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory