Fga
Gene Detail

Symbol Name ID

Fga fibrinogen alpha chain MGI:1316726

Synonyms

ENSMUSG00000059807, Fib

Feature Type

protein coding gene

Genetic Map

Chromosome 3

36.96 cM, cytoband F1
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr3:83026153-83033615 bp, + strand From Ensembl annotation of GRCm38   7463 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:428  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Fga

Human homologs

Human Homolog		FGA, fibrinogen alpha chain
NCBI Gene ID		2243
neXtProt AC		NX_P02671
Human Synonyms		Fib2
Human Chr (Location)		4q28; chr4:155504280-155511897 (-)  GRCh37.p10
Disease Associations		(3) Diseases Associated with Human FGA

Alleles and phenotypes

All alleles(3) : Targeted(3)
 

Mice homozygous for disruptions of this gene have blood that is unable to clot. On some genetic backgrounds this can lead to fatal hemorrhaging.

 

Gene Ontology (GO) classifications

All GO classifications: (9 annotations)

Process	blood coagulation, response to calcium ion
Component	blood microparticle, cell cortex, ...
Function	eukaryotic cell surface binding

External Resources: FuncBase

Expression

Literature Summary: (11 records)
Data Summary: Results (64)    Tissues (29)    Images (35)
Theiler Stages: 11, 12, 13, 15, 17, 19, 20, 21, 22, 23, 24, 25, 28

Assay Type	Results
Immunohistochemistry	30
RNA in situ	23
RT-PCR	11

cDNA source data(190)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(194) Genomic(1) cDNA(190) Primer pair(2) Other(1)
Microarray probesets(4)

Other database links

Ensembl Gene Model	ENSMUSG00000028001 (Evidence)
Entrez Gene	14161 (Evidence)
UniGene	88793
DFCI	TC1574510, TC1651333
DoTS	DT.40164731, DT.91432881, DT.94172791
NIA Mouse Gene Index	U003364
Consensus CDS Project	CCDS17431.1, CCDS50939.1
International Mouse Knockout Project Status	Fga

Sequences

Length	Strain/Species
genomic	ENSMUSG00000028001	Ensembl Gene Model | MGI Sequence Detail	7463	C57BL/6J
transcript	ENSMUST00000166581	Ensembl | MGI Sequence Detail	2637	Not Applicable
polypeptide	ENSMUSP00000133117	Ensembl | MGI Sequence Detail	789	Not Applicable

All sequences(27) RefSeq(4) UniProt(2)

Polymorphisms

SNPs(50 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR012290	Fibrinogen, alpha/beta/gamma chain, coiled coil domain
InterPro	IPR002181	Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
InterPro	IPR014716	Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1
InterPro	IPR014715	Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 2
InterPro	IPR021996	Fibrinogen alpha C domain
InterPro	IPR020837	Fibrinogen, conserved site
Protein Ontology	PR:000007471	fibrinogen alpha chain

References

(Earliest) J:15567 Warden CH, et al., Linkage mapping of 40 randomly isolated liver cDNA clones in the mouse. Genomics. 1993 Nov;18(2):295-307
(Latest) J:194888 Luo D, et al., Fibrin Facilitates Both Innate and T Cell-Mediated Defense against Yersinia pestis. J Immunol. 2013 Apr 15;190(8):4149-61
All references(88)

Other accession IDs

MGI:2139659, MGI:3642492