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Lhx9 Gene Detail
Summary
  • Symbol
    Lhx9
  • Name
    LIM homeobox protein 9
  • Synonyms
    3110009O07Rik, LH2B, Lhx9 alpha
  • Feature Type
    protein coding gene
  • IDs
    MGI:1316721
    NCBI Gene: 16876
Location & Maps
more
  • Sequence Map
    Chr1:138825186-138848577 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      23392 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 60.82 cM, cytoband G-H2
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    LHX9, LIM homeobox 9
  • Vertebrate Orthologs
    10
  • Human Ortholog
    LHX9, LIM homeobox 9
    Orthology source: HGNC, HomoloGene
  • Links
    NCBI Gene ID: 56956
    neXtProt AC: NX_Q9NQ69

  • Chr Location
    1q31.1; chr1:197912505-197935476 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 7816
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: LHX9
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    19 phenotypes from 2 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    1 images
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    10
  • Chemically induced (other)
    2
  • Radiation induced
    1
  • Targeted
    7
  • Genomic Mutations
    3 involving Lhx9
  • Incidental Mutations
Homozygotes for a targeted null mutation exhibit failed proliferation of the somatic cells of the genital ridge resulting in lack of discrete gonad formation, infertility in both sexes, and female-like genitalia in genetically male mice.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022572 VEGA Gene Model | MGI Sequence Detail 23392 C57BL/6J ±  kb
transcript OTTMUST00000054115 VEGA | MGI Sequence Detail 2065 Not Applicable  
polypeptide OTTMUSP00000025782 VEGA | MGI Sequence Detail 397 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    130 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 34
    Genomic 1
    cDNA 24
    Primer pair 5
    Other 4

    Microarray probesets 6
Other
Accession IDs
less
MGI:1920327, MGI:2138632
References
more
  • Summaries
    All 147
    Developmental Gene Expression 119
    Gene Ontology 4
    Phenotypes 14
  • Earliest
    J:50972 Lee KJ, et al., Neuronal patterning by BMPs: a requirement for GDF7 in the generation of a discrete class of commissural interneurons in the mouse spinal cord. Genes Dev. 1998 Nov 1;12(21):3394-407
  • Latest
    J:226857 Yang Y, et al., Lhx9 gene expression during early limb development in mice requires the FGF signalling pathway. Gene Expr Patterns. 2015 Sep-Nov;19(1-2):45-51

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory