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Ifrd1
Gene Detail
Symbol

Name
ID
Ifrd1
interferon-related developmental regulator 1
MGI:1316717
Synonyms
Ifnl, PC4, Tis7
Feature Type
protein coding gene
Genetic Map
Chromosome 12
18.06 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr12:40201567-40248504 bp, - strand
From VEGA annotation of GRCm38

  46938 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:31043  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Ifrd1

Human
homologs
Human Homolog IFRD1, interferon-related developmental regulator 1
NCBI Gene ID 3475
neXtProt AC  NX_O00458
Human Synonyms  PC4, TIS7
Human Chr (Location)  7q31.1; chr7:112423144-112477203 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Gene trapped(8) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice display impaired muscle regeneration and myogenic differentiation and decreased body weight in older mice.
 
Interactions
Ifrd1 interacts with 242 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (3 records)
Data Summary: Results (123)    Tissues (44)    Images (21)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 123
cDNA source data(149)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(153) cDNA(152) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000035474 (Evidence)
Ensembl Gene ModelENSMUSG00000001627 (Evidence)
Entrez Gene15982 (Evidence)
UniGene168
DFCITC1604801, TC1572542
DoTSDT.494584, DT.94407433
NIA Mouse Gene IndexU033912
Consensus CDS ProjectCCDS25893.1
International Mouse Knockout Project StatusIfrd1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035474 VEGA Gene Model | MGI Sequence Detail 46938 C57BL/6J ±  kb
transcript OTTMUST00000090788 VEGA | MGI Sequence Detail 3378 Not Applicable 
polypeptide OTTMUSP00000049857 VEGA | MGI Sequence Detail 449 Not Applicable 

For the selected sequences
All sequences(74) RefSeq(2) UniProt(15)
Polymorphisms
SNPs within 2kb(269 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011989 Armadillo-like helical
InterPro IPR016024 Armadillo-type fold
InterPro IPR006921 Interferon-related developmental regulator, C-terminal
InterPro IPR007701 Interferon-related developmental regulator, N-terminal
Protein Ontology PR:000008929 interferon-related developmental regulator 1
References
(Earliest) J:6817 Skup D, et al., Molecular cloning of partial cDNA copies of two distinct mouse IFN-beta mRNAs. Nucleic Acids Res. 1982 May 25;10(10):3069-84
(Latest) J:202418 Nakamura Y, et al., Repression of adipogenesis through promotion of Wnt/beta-catenin signaling by TIS7 up-regulated in adipocytes under hypoxia. Biochim Biophys Acta. 2013 Aug;1832(8):1117-28
All references(44)
Other
accession IDs
MGD-MRK-37140, MGI:108103

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory