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Ifrd2 Gene Detail
Summary
  • Symbol
    Ifrd2
  • Name
    interferon-related developmental regulator 2
  • Synonyms
    1810034A24Rik, SKMc15
  • Feature Type
    protein coding gene
  • IDs
    MGI:1316708
    NCBI Gene: 15983
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:107464917-107470237 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 58.24 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    202 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1316708
 protein coding gene Chr9:107464841-107470584 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035263
 protein coding gene Chr9:109472445-109478231 (+)
A/J MGP_AJ_G0035242
 protein coding gene Chr9:105484511-105491072 (+)
AKR/J MGP_AKRJ_G0035174
 protein coding gene Chr9:108118238-108124056 (+)
BALB/cJ MGP_BALBcJ_G0035236
 protein coding gene Chr9:105153964-105159771 (+)
C3H/HeJ MGP_C3HHeJ_G0034946
 protein coding gene Chr9:108515847-108522185 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035756
 protein coding gene Chr9:112454623-112460331 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032654
 protein coding gene Chr9:102914179-102919751 (+)
CAST/EiJ MGP_CASTEiJ_G0034257
 protein coding gene Chr9:108450317-108456100 (+)
CBA/J MGP_CBAJ_G0034914
 protein coding gene Chr9:116428476-116434096 (+)
DBA/2J MGP_DBA2J_G0035075
 protein coding gene Chr9:104938311-104944054 (+)
FVB/NJ MGP_FVBNJ_G0035023
 protein coding gene Chr9:103704201-103710479 (+)
LP/J MGP_LPJ_G0035151
 protein coding gene Chr9:109670218-109676023 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035062
 protein coding gene Chr9:118041763-118048613 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035777
 protein coding gene Chr9:108392279-108398061 (+)
PWK/PhJ MGP_PWKPhJ_G0033964
 protein coding gene Chr9:105258928-105264772 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033799
 protein coding gene Chr9:108443887-108449639 (+)
WSB/EiJ MGP_WSBEiJ_G0034378
 protein coding gene Chr9:108272122-108277925 (+)



Homology
more
  • Human Ortholog
    IFRD2, interferon related developmental regulator 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IFRD2, interferon related developmental regulator 2
  • Synonyms
    IFNRP, SKMc15, SM15
  • Links
    NCBI Gene ID: 7866
    UniProt: Q12894

  • Chr Location
    3p21.31; chr3:50287732-50292918 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    7 phenotypes from multigenic genotypes
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Male mice homozygous for a null mutation display decreased body weight, decreased fat amount and impaired white adipocyte differentiation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    752
  • Tissues
    28
  • cDNA Data
    13
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 15983 NCBI Gene Model | MGI Sequence Detail 5321 C57BL/6J ±  kb
    transcript NM_025903 RefSeq | MGI Sequence Detail 1980 ZRU/MplStud  
    polypeptide Q9D8U0 UniProt | EBI | MGI Sequence Detail 441 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000008930 interferon-related developmental regulator 2
      (term hierarchy)
    • InterPro Domains
      IPR011989 Armadillo-like helical
      IPR016024 Armadillo-type fold
      IPR039777 Interferon-related developmental regulator
      IPR006921 Interferon-related developmental regulator, C-terminal
      IPR007701 Interferon-related developmental regulator, N-terminal
    Molecular
    Reagents
    less
    • All nucleic 14
      cDNA 13
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1914257, MGI:2142941, MGI:2143129
    References
    more
    • Summaries
      All 38
      Developmental Gene Expression 3
      Gene Ontology 5
      Phenotypes 9
    • Earliest
      J:49566 Buanne P, et al., Cloning of the human interferon-related developmental regulator (IFRD1) gene coding for the PC4 protein, a member of a novel family of developmentally regulated genes. Genomics. 1998 Jul 15;51(2):233-42
    • Latest
      J:344868 Vietor I, et al., The negative adipogenesis regulator Dlk1 is transcriptionally regulated by Ifrd1 (TIS7) and translationally by its orthologue Ifrd2 (SKMc15). Elife. 2023 Aug 21;12
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    03/25/2025
    MGI 6.24     		The Jackson Laboratory